Player_Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Azeez Ojulari | LAR | O LB | 16 | 94 |
| Trey Hendrickson | OAK | Right End | 10 | 74 |
| Quinnen Williams | SCS | Right Tackle | 10 | 65 |
| Nik Bonitto | LAC | Right O LB | 8 | 56 |
| Myles Garrett | CLE | Left End | 8 | 54 |
| Will Anderson Jr. | CAL | Left End | 7 | 53 |
| Danielle Hunter | WAS | Right End | 7 | 37 |
| Devonte Wyatt | LAC | Def Tackle | 7 | 27 |
| Za'Darius Smith | SEA | Left End | 6 | 50 |
| Dadrion Taylor-Demerson | BAL | Safety | 6 | 49 |
| Montez Sweat | OAK | Left End | 6 | 47 |
| Micah Parsons | OAK | Right End | 6 | 47 |
| Josh Hines-Allen | LAC | Left End | 6 | 47 |
| Nick Bosa | CLE | Right End | 6 | 44 |
| Will McDonald IV | LAR | Left End | 6 | 35 |
| DaQuan Jones | BUF | Left Tackle | 6 | 30 |
| Harold Landry | DET | Left O LB | 5 | 40 |
| Travon Walker | LAC | Right End | 5 | 39 |
| Malcolm Rodriguez | CHI | Right LB | 5 | 34 |
| Matthew Judon | DAL | Right O LB | 5 | 33 |
| Alex Highsmith | DET | Right O LB | 5 | 31 |
| George Karlaftis | NOV | Left End | 5 | 31 |
| Adam Butler | LAR | Right Tackle | 5 | 31 |
| Bobby Wagner | SEA | Middle LB | 5 | 31 |
| Rashan Gary | PHI | Right End | 5 | 28 |
| Brian Burns | DAL | Right O LB | 5 | 25 |
| Christian Rozeboom | CAL | Left I LB | 5 | 13 |
| Derek Barnett | NYG | Def End | 4 | 36 |
| A.J. Epenesa | TTR | Right End | 4 | 34 |
| Julian Love | NYG | Free Safety | 4 | 33 |
| Zach Allen | SHR | Left End | 4 | 27 |
| DeMarvion Overshown | NOV | Left LB | 4 | 26 |
| T.J. Watt | PHO | Left O LB | 4 | 25 |
| Jonathan Greenard | SEA | Right O LB | 4 | 22 |
| D.J. Reader | BAL | Right Tackle | 4 | 22 |
| T.J. Slaton | MIS | Right Tackle | 4 | 20 |
| Antoine Winfield Jr. | BAL | Free Safety | 4 | 18 |
| Calais Campbell | BAL | Left End | 4 | 15 |
| Elandon Roberts | TTR | Right I LB | 4 | 2 |
| Cameron Jordan | DET | Left End | 3 | 24 |
| Ed Oliver | GBP | Right Tackle | 3 | 23 |
| Kwity Paye | JAC | Left End | 3 | 22 |
| Maxx Crosby | TTR | Left End | 3 | 19 |
| Dexter Lawrence | CHI | Nose Tackle | 3 | 19 |
| Chris Jones | WAS | Right Tackle | 3 | 18 |
| Boye Mafe | CLE | Left O LB | 3 | 16 |
| Khalil Mack | CHI | Left O LB | 3 | 15 |
| Roy Lopez | NOV | Nose Tackle | 3 | 12 |
| Fred Warner | PHO | Middle LB | 3 | 11 |
| Zack Baun | CLE | Left I LB | 3 | 9 |
| D.J. Jones | SEA | Nose Tackle | 3 | 8 |
| T'Vondre Sweat | DET | Nose Tackle | 3 | 3 |
| Zaven Collins | LAC | Left O LB | 2 | 22 |
| Carl Lawson | GBP | Def End | 2 | 20 |
| Jaylon Carlies | SCS | Left LB | 2 | 19 |
| Josh Sweat | PHI | Left O LB | 2 | 18 |
| Andrew Van Ginkel | JAC | Left O LB | 2 | 17 |
| Zach Sieler | PHO | Right Tackle | 2 | 17 |
| Leonard Williams | CHI | Right End | 2 | 17 |
| Dee Winters | CLE | Left LB | 2 | 16 |
| Leonard Floyd | PHO | Left End | 2 | 16 |
| Laiatu Latu | LAR | Def End | 2 | 15 |
| Greg Rousseau | NOV | Left End | 2 | 15 |
| DeShon Elliott | PHO | Strong Safety | 2 | 14 |
| Tershawn Wharton | MIS | Left Tackle | 2 | 14 |
| Pete Werner | OAK | Right LB | 2 | 14 |
| Kayvon Thibodeaux | WAS | Right End | 2 | 14 |
| Jalen Carter | BAL | Right End | 2 | 14 |
| K'Lavon Chaisson | CHI | Def End | 2 | 12 |
| Jake Martin | PHI | Def End | 2 | 12 |
| Xavier Woods | SCS | Free Safety | 2 | 12 |
| Arden Key | CIN | Right O LB | 2 | 10 |
| Terrion Arnold | CHI | Right CB | 2 | 9 |
| Jeremy Chinn | LAC | Strong Safety | 2 | 9 |
| Jonathan Allen | PHO | Right Tackle | 2 | 8 |
| Bryan Bresee | LAR | Right Tackle | 2 | 7 |
| Andrew Billings | SHR | Left Tackle | 2 | 6 |
| Keeanu Benton | CAL | Nose Tackle | 2 | 3 |
| Jack Campbell | NYG | Middle LB | 2 | 0 |
| Jordan Davis | DAL | Nose Tackle | 2 | 0 |
| Alim McNeill | SHR | Left Tackle | 2 | 0 |
| Demario Davis | TTR | Middle LB | 2 | 0 |
| Carl Granderson | DAL | Right End | 1 | 12 |
| Minkah Fitzpatrick | MIS | Free Safety | 1 | 11 |
| Rasul Douglas | PHI | Right CB | 1 | 11 |
| Byron Young | NOS | Right O LB | 1 | 11 |
| DeMarcus Walker | NOS | Right End | 1 | 10 |
| Charles Snowden | NOV | Left LB | 1 | 10 |
| Jerome Baker | BUF | Right I LB | 1 | 10 |
| Joshua Williams | SCS | Right CB | 1 | 10 |
| Dante Stills | BUF | Left End | 1 | 9 |
| Jalyx Hunt | CIN | O LB | 1 | 9 |
| Quincy Williams | SEA | Left LB | 1 | 9 |
| Nick Herbig | CHI | O LB | 1 | 9 |
| Mazi Smith | CLE | Left Tackle | 1 | 8 |
| Joe Tryon-Shoyinka | NYG | Left O LB | 1 | 8 |
| Nnamdi Madubuike | NYG | Left End | 1 | 8 |
| Alex Anzalone | CAL | Left LB | 1 | 8 |
| Ashtyn Davis | DAL | 1st Defensive Back | 1 | 8 |
| Sauce Gardner | CAL | Left CB | 1 | 8 |
| Joey Bosa | PHI | Left End | 1 | 8 |
| John Franklin-Myers | SCS | Right End | 1 | 7 |
| Bryce Huff | SHR | O LB | 1 | 7 |
| Malik Mustapha | CIN | Strong Safety | 1 | 7 |
| Vita Vea | TTR | Nose Tackle | 1 | 7 |
| Charles Harris | WAS | O LB | 1 | 7 |
| Brandon Jones | CHI | Strong Safety | 1 | 6 |
| Frankie Luvu | TTR | Right LB | 1 | 6 |
| Nolan Smith | JAC | Right O LB | 1 | 6 |
| Odafe Oweh | MIS | O LB | 1 | 6 |
| Sam Hubbard | MIS | Left End | 1 | 6 |
| Kevin Byard III | OAK | Free Safety | 1 | 6 |
| George Odum | LAR | Safety | 1 | 6 |
| Brandon Graham | BAL | O LB | 1 | 5 |
| Robert Spillane | CHI | Middle LB | 1 | 5 |
| Travis Jones | JAC | Nose Tackle | 1 | 5 |
| B.J. Hill | BAL | Right Tackle | 1 | 5 |
| D.J. Wonnum | NOV | Right O LB | 1 | 5 |
| Cameron Heyward | SCS | Right End | 1 | 5 |
| Jordan Elliott | CLE | Right Tackle | 1 | 4 |
| Kingsley Enagbare | SCS | Left End | 1 | 4 |
| Jamien Sherwood | OAK | Middle LB | 1 | 4 |
| Keion White | GBP | Right O LB | 1 | 4 |
| Justin Strnad | LAR | Left I LB | 1 | 3 |
| Xavier McKinney | SEA | Free Safety | 1 | 3 |
| Kyle Van Noy | BUF | Left O LB | 1 | 3 |
| Eric Kendricks | NOS | Middle LB | 1 | 3 |
| Micheal Clemons | NOS | Right End | 1 | 3 |
| Dondrea Tillman | BAL | O LB | 1 | 3 |
| Dennis Gardeck | LAR | O LB | 1 | 3 |
| Eric Murray | PHI | Free Safety | 1 | 2 |
| DeForest Buckner | OAK | Left Tackle | 1 | 0 |
| Lavonte David | JAC | Right I LB | 1 | 0 |
| Nathan Shepherd | SCS | Left Tackle | 1 | 0 |
| Kenny Clark | GBP | Left Tackle | 1 | 0 |
| Eddie Goldman | PHI | Nose Tackle | 1 | 0 |
| Harrison Phillips | NOS | Nose Tackle | 1 | 0 |
| Nick Bolton | NOV | Middle LB | 1 | 0 |
| Luke Masterson | DAL | LB | 1 | 0 |
| Devin Lloyd | CHI | Middle LB | 1 | 0 |
| Kenneth Murray | LAC | Left I LB | 1 | 0 |
| Derwin James | SHR | Strong Safety | 1 | 0 |
| Sum | --- | --- | 383 | 2297 |
| Avg | --- | --- | 3 | 16 |