Player_Defense
| NameFL | TAbb | PosN | T | OppFumR | Sack | SackYds | Int | IntY | IntAvg | IntTDs |
| Jerome Baker | BUF | Right I LB | 141 | 2 | 1 | 10 | 0 | 0 | 0.0 | 0 |
| Jack Campbell | NYG | Middle LB | 133 | 1 | 3 | 1 | 0 | 0 | 0.0 | 0 |
| Ernest Jones | GBP | Right I LB | 130 | 2 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Alex Anzalone | CAL | Left LB | 129 | 1 | 2 | 14 | 1 | 13 | 13.0 | 0 |
| Christian Gonzalez | CIN | Right CB | 127 | 0 | 0 | 0 | 1 | 20 | 20.0 | 0 |
| Nolan Smith | JAC | Right O LB | 125 | 1 | 1 | 6 | 2 | 25 | 12.5 | 0 |
| Zack Baun | CLE | Left I LB | 120 | 0 | 3 | 9 | 2 | 16 | 8.0 | 0 |
| Tyrice Knight | SCS | Left I LB | 119 | 0 | 0 | 0 | 1 | 4 | 4.0 | 0 |
| Foyesade Oluokun | SCS | Right LB | 117 | 1 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Elandon Roberts | TTR | Right I LB | 116 | 0 | 4 | 2 | 1 | 25 | 25.0 | 0 |
| Brandon Graham | BAL | O LB | 115 | 1 | 2 | 14 | 0 | 0 | 0.0 | 0 |
| Jordan Hicks | PHI | Middle LB | 115 | 1 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Malcolm Rodriguez | CHI | Right LB | 113 | 0 | 6 | 43 | 3 | 29 | 9.7 | 0 |
| Jack Gibbens | BAL | I LB | 111 | 1 | 0 | 0 | 2 | 12 | 6.0 | 0 |
| Charles Harris | WAS | O LB | 110 | 0 | 1 | 7 | 0 | 0 | 0.0 | 0 |
| Quay Walker | MIS | Middle LB | 110 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Josey Jewell | SHR | Right I LB | 109 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Jalyx Hunt | CIN | O LB | 106 | 1 | 1 | 9 | 0 | 0 | 0.0 | 0 |
| Omar Speights | CIN | Right I LB | 106 | 1 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Justin Strnad | LAR | Left I LB | 105 | 1 | 1 | 3 | 0 | 0 | 0.0 | 0 |
| Devin Lloyd | CHI | Middle LB | 104 | 0 | 2 | 0 | 0 | 0 | 0.0 | 0 |
| Jeremiah Owusu-Koramoah | GBP | Right LB | 103 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Tarheeb Still | NOV | Left CB | 102 | 0 | 0 | 0 | 3 | 72 | 24.0 | 1 |
| Dondrea Tillman | BAL | O LB | 101 | 1 | 1 | 3 | 0 | 0 | 0.0 | 0 |
| Tavius Robinson | SHR | Right O LB | 101 | 1 | 0 | 0 | 2 | 84 | 42.0 | 1 |
| Neville Hewitt | BUF | Left LB | 101 | 2 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| T.J. Watt | PHO | Left O LB | 100 | 0 | 4 | 25 | 0 | 0 | 0.0 | 0 |
| Daiyan Henley | JAC | Left I LB | 100 | 0 | 0 | 0 | 1 | 13 | 13.0 | 0 |
| Mike Hughes | CIN | Left CB | 100 | 2 | 0 | 0 | 2 | 25 | 12.5 | 0 |
| Micah Parsons | OAK | Right End | 99 | 1 | 7 | 54 | 1 | 15 | 15.0 | 0 |
| Renardo Green | BAL | Right CB | 98 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Christian Rozeboom | CAL | Left I LB | 97 | 0 | 5 | 13 | 0 | 0 | 0.0 | 0 |
| Boye Mafe | CLE | Left O LB | 97 | 1 | 3 | 16 | 0 | 0 | 0.0 | 0 |
| Jamien Sherwood | OAK | Middle LB | 97 | 2 | 1 | 4 | 0 | 0 | 0.0 | 0 |
| Taylor Rapp | GBP | Strong Safety | 97 | 0 | 0 | 0 | 1 | 25 | 25.0 | 0 |
| Nate Landman | DAL | Left I LB | 97 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Quinyon Mitchell | LAR | Left CB | 96 | 1 | 0 | 0 | 1 | 0 | 0.0 | 0 |
| Azeez Ojulari | LAR | O LB | 95 | 1 | 21 | 119 | 0 | 0 | 0.0 | 0 |
| Harold Landry | DET | Left O LB | 95 | 0 | 5 | 40 | 0 | 0 | 0.0 | 0 |
| Eric Kendricks | NOS | Middle LB | 95 | 1 | 1 | 3 | 0 | 0 | 0.0 | 0 |
| Eric Wilson | TTR | Right LB | 92 | 2 | 0 | 0 | 1 | 25 | 25.0 | 0 |
| Justin Simmons | LAR | Free Safety | 92 | 0 | 0 | 0 | 1 | 25 | 25.0 | 0 |
| Lavonte David | JAC | Right I LB | 91 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0 |
| Kyle Van Noy | BUF | Left O LB | 91 | 1 | 1 | 3 | 0 | 0 | 0.0 | 0 |
| A.J. Terrell | GBP | Right CB | 91 | 0 | 0 | 0 | 1 | 0 | 0.0 | 0 |
| Zaven Collins | LAC | Left O LB | 90 | 1 | 3 | 23 | 4 | 36 | 9.0 | 0 |
| Keisean Nixon | MIS | Left CB | 90 | 1 | 0 | 0 | 4 | 35 | 8.8 | 0 |
| Dennis Gardeck | LAR | O LB | 89 | 0 | 3 | 16 | 1 | 25 | 25.0 | 0 |
| Nakobe Dean | NOV | Right I LB | 89 | 1 | 1 | 0 | 0 | 0 | 0.0 | 0 |
| Samuel Womack III | NOS | Left CB | 89 | 0 | 0 | 0 | 2 | 22 | 11.0 | 0 |
| Blake Cashman | DET | Right I LB | 89 | 0 | 0 | 0 | 1 | 0 | 0.0 | 0 |
| DaRon Bland | TTR | Left CB | 89 | 0 | 0 | 0 | 2 | 27 | 13.5 | 0 |
| Byron Murphy | NYG | Right CB | 88 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Bobby Wagner | SEA | Middle LB | 87 | 0 | 6 | 43 | 1 | 12 | 12.0 | 0 |
| Matthew Judon | DAL | Right O LB | 87 | 0 | 5 | 33 | 0 | 0 | 0.0 | 0 |
| Luke Masterson | DAL | LB | 87 | 0 | 2 | 0 | 0 | 0 | 0.0 | 0 |
| Montaric Brown | LAR | Right CB | 87 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Patrick Jones II | NYG | O LB | 86 | 4 | 2 | 18 | 1 | 22 | 22.0 | 0 |
| Jalen Ramsey | DAL | Right CB | 86 | 0 | 0 | 0 | 3 | 28 | 9.3 | 1 |
| Frankie Luvu | TTR | Right LB | 85 | 1 | 2 | 11 | 1 | 37 | 37.0 | 1 |
| Jadeveon Clowney | MIS | Left O LB | 85 | 0 | 0 | 0 | 1 | 20 | 20.0 | 0 |
| Kendall Fuller | SCS | Left CB | 85 | 0 | 0 | 0 | 3 | 26 | 8.7 | 0 |
| Fred Warner | PHO | Middle LB | 83 | 0 | 4 | 19 | 0 | 0 | 0.0 | 0 |
| Josh Sweat | PHI | Left O LB | 83 | 3 | 2 | 18 | 1 | 22 | 22.0 | 0 |
| Kenneth Murray | LAC | Left I LB | 83 | 1 | 1 | 0 | 2 | 35 | 17.5 | 0 |
| Jamel Dean | WAS | Left CB | 83 | 0 | 0 | 0 | 1 | 13 | 13.0 | 0 |
| Denzel Ward | LAC | Left CB | 83 | 0 | 0 | 0 | 1 | 0 | 0.0 | 0 |
| Kaden Elliss | CAL | Right I LB | 83 | 1 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Dexter Lawrence | CHI | Nose Tackle | 82 | 1 | 8 | 41 | 0 | 0 | 0.0 | 0 |
| Odafe Oweh | MIS | O LB | 81 | 1 | 1 | 6 | 4 | 36 | 9.0 | 0 |
| Arden Key | CIN | Right O LB | 80 | 0 | 3 | 11 | 0 | 0 | 0.0 | 0 |
| Malik Mustapha | CIN | Strong Safety | 80 | 1 | 1 | 7 | 2 | 10 | 5.0 | 0 |
| Charvarius Ward | JAC | Left CB | 80 | 0 | 0 | 0 | 1 | 25 | 25.0 | 0 |
| Devon Witherspoon | BUF | Right CB | 80 | 1 | 0 | 0 | 3 | 20 | 6.7 | 0 |
| Chazz Surratt | PHI | Right LB | 80 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Nate Wiggins | BAL | Left CB | 79 | 0 | 0 | 0 | 1 | 0 | 0.0 | 0 |
| Budda Baker | LAC | Free Safety | 79 | 1 | 0 | 0 | 4 | 77 | 19.3 | 1 |
| Mike Sainristil | NOV | Right CB | 78 | 0 | 0 | 0 | 1 | 12 | 12.0 | 0 |
| Michael Jackson Sr. | PHO | Left CB | 78 | 0 | 0 | 0 | 4 | 46 | 11.5 | 0 |
| Isaiah McDuffie | SEA | Left LB | 78 | 1 | 0 | 0 | 3 | 20 | 6.7 | 0 |
| Bryan Cook | OAK | Free Safety | 77 | 0 | 0 | 0 | 4 | 10 | 2.5 | 0 |
| Trevon Diggs | NOS | Right CB | 77 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Jaycee Horn | DAL | Right CB | 76 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Ronnie Hickman Jr. | DAL | Safety | 76 | 0 | 0 | 0 | 1 | 4 | 4.0 | 0 |
| Trent McDuffie | SHR | Left CB | 76 | 1 | 0 | 0 | 1 | 4 | 4.0 | 0 |
| Joe Tryon-Shoyinka | NYG | Left O LB | 75 | 0 | 1 | 8 | 0 | 0 | 0.0 | 0 |
| Joey Porter Jr. | WAS | Right CB | 75 | 0 | 0 | 0 | 1 | 25 | 25.0 | 0 |
| Derek Stingley Jr. | NYG | Left CB | 75 | 0 | 0 | 0 | 7 | 93 | 13.3 | 1 |
| Byron Young | NOS | Right O LB | 74 | 0 | 3 | 30 | 0 | 0 | 0.0 | 0 |
| Demario Davis | TTR | Middle LB | 74 | 0 | 2 | 0 | 0 | 0 | 0.0 | 0 |
| Isaiah Rodgers | SCS | 1st Defensive Back | 74 | 0 | 0 | 0 | 6 | 25 | 4.2 | 0 |
| Jaylon Johnson | OAK | Left CB | 74 | 0 | 0 | 0 | 4 | 23 | 5.8 | 0 |
| Quincy Williams | SEA | Left LB | 73 | 0 | 2 | 21 | 1 | 0 | 0.0 | 0 |
| Coby Bryant | CIN | Strong Safety | 73 | 0 | 0 | 0 | 5 | 61 | 12.2 | 0 |
| Christian Benford | PHI | Left CB | 73 | 0 | 0 | 0 | 1 | 0 | 0.0 | 0 |
| Nick Bolton | NOV | Middle LB | 71 | 0 | 1 | 0 | 1 | 12 | 12.0 | 0 |
| Jonathan Jones | PHO | Left CB | 71 | 0 | 0 | 0 | 2 | 74 | 37.0 | 1 |
| Kamari Lassiter | MIS | Right CB | 71 | 0 | 0 | 0 | 1 | 15 | 15.0 | 0 |
| Quandre Diggs | WAS | Free Safety | 70 | 0 | 0 | 0 | 1 | 25 | 25.0 | 0 |
| Riq Woolen | GBP | Left CB | 70 | 0 | 0 | 0 | 3 | 34 | 11.3 | 0 |
| Jordan Poyer | PHO | Strong Safety | 70 | 0 | 0 | 0 | 1 | 12 | 12.0 | 0 |
| Edgerrin Cooper | NOS | LB | 70 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Keion White | GBP | Right O LB | 69 | 1 | 1 | 4 | 0 | 0 | 0.0 | 0 |
| Camryn Bynum | CAL | Free Safety | 69 | 0 | 0 | 0 | 1 | 0 | 0.0 | 0 |
| Zyon McCollum | SEA | Right CB | 69 | 0 | 0 | 0 | 3 | 30 | 10.0 | 0 |
| Alex Highsmith | DET | Right O LB | 68 | 3 | 5 | 31 | 0 | 0 | 0.0 | 0 |
| Derick Hall | NOS | Right O LB | 68 | 5 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| D.J. Reed | JAC | Right CB | 68 | 0 | 0 | 0 | 4 | 17 | 4.3 | 0 |
| Robert Spillane | CHI | Middle LB | 67 | 1 | 1 | 5 | 0 | 0 | 0.0 | 0 |
| C.J. Gardner-Johnson | MIS | Strong Safety | 67 | 0 | 0 | 0 | 3 | 55 | 18.3 | 0 |
| Pete Werner | OAK | Right LB | 66 | 1 | 2 | 14 | 1 | 22 | 22.0 | 0 |
| Minkah Fitzpatrick | MIS | Free Safety | 66 | 0 | 1 | 11 | 1 | 0 | 0.0 | 0 |
| Chuck Clark | LAC | Strong Safety | 66 | 1 | 0 | 0 | 1 | 0 | 0.0 | 0 |
| Payton Wilson | SHR | LB | 66 | 0 | 0 | 0 | 1 | 12 | 12.0 | 0 |
| Elijah Hicks | DET | Strong Safety | 66 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Harrison Smith | NOS | Strong Safety | 66 | 0 | 0 | 0 | 2 | 25 | 12.5 | 0 |
| Nik Bonitto | LAC | Right O LB | 65 | 0 | 13 | 81 | 0 | 0 | 0.0 | 0 |
| Kerby Joseph | WAS | Free Safety | 65 | 0 | 0 | 0 | 5 | 72 | 14.4 | 0 |
| Darious Williams | CLE | Right CB | 65 | 0 | 0 | 0 | 3 | 81 | 27.0 | 1 |
| Grant Delpit | JAC | Strong Safety | 65 | 0 | 0 | 0 | 2 | 34 | 17.0 | 0 |
| Jared Verse | WAS | Left O LB | 65 | 0 | 0 | 0 | 1 | 13 | 13.0 | 0 |
| Brian Burns | DAL | Right O LB | 64 | 1 | 6 | 30 | 0 | 0 | 0.0 | 0 |
| Terrion Arnold | CHI | Right CB | 64 | 0 | 2 | 9 | 4 | 48 | 12.0 | 0 |
| Rasul Douglas | PHI | Right CB | 63 | 0 | 1 | 11 | 2 | 12 | 6.0 | 0 |
| Stephon Gilmore | LAC | Left CB | 63 | 0 | 0 | 0 | 3 | 32 | 10.7 | 0 |
| T'Vondre Sweat | DET | Nose Tackle | 62 | 2 | 4 | 3 | 0 | 0 | 0.0 | 0 |
| Brandon Jones | CHI | Strong Safety | 62 | 0 | 1 | 6 | 3 | 22 | 7.3 | 0 |
| Dee Winters | CLE | Left LB | 61 | 2 | 3 | 26 | 0 | 0 | 0.0 | 0 |
| Carrington Valentine | SHR | Right CB | 61 | 0 | 0 | 0 | 1 | 0 | 0.0 | 0 |
| Pat Surtain II | DET | Left CB | 61 | 0 | 0 | 0 | 2 | 62 | 31.0 | 1 |
| Carlton Davis | DET | Left CB | 61 | 0 | 0 | 0 | 3 | 78 | 26.0 | 1 |
| Patrick Queen | WAS | Left I LB | 61 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Dadrion Taylor-Demerson | BAL | Safety | 60 | 0 | 11 | 83 | 3 | 34 | 11.3 | 0 |
| DeMarvion Overshown | NOV | Left LB | 60 | 1 | 5 | 34 | 1 | 13 | 13.0 | 0 |
| Joshua Williams | SCS | Right CB | 60 | 0 | 1 | 10 | 2 | 25 | 12.5 | 0 |
| Sauce Gardner | CAL | Left CB | 60 | 1 | 1 | 8 | 2 | 15 | 7.5 | 0 |
| Brian Branch | DET | Strong Safety | 60 | 0 | 1 | 9 | 0 | 0 | 0.0 | 0 |
| Calen Bullock | SHR | Strong Safety | 60 | 0 | 0 | 0 | 1 | 4 | 4.0 | 0 |
| Kyle Hamilton | CLE | Strong Safety | 60 | 0 | 0 | 0 | 3 | 12 | 4.0 | 0 |
| Dallas Turner | PHO | O LB | 60 | 0 | 0 | 0 | 1 | 73 | 73.0 | 1 |
| Khalil Mack | CHI | Left O LB | 59 | 2 | 3 | 15 | 1 | 8 | 8.0 | 1 |
| Jack Jones | CHI | Left CB | 59 | 1 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Geno Stone | NOV | Free Safety | 58 | 0 | 0 | 0 | 1 | 25 | 25.0 | 0 |
| Juan Thornhill | PHI | Free Safety | 57 | 0 | 0 | 0 | 1 | 0 | 0.0 | 0 |
| Tyrann Mathieu | TTR | Free Safety | 57 | 0 | 0 | 0 | 2 | 10 | 5.0 | 0 |
| Jalen Mills | SEA | Safety | 57 | 1 | 0 | 0 | 2 | 13 | 6.5 | 0 |
| Justin Reid | BUF | Strong Safety | 57 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Julian Love | NYG | Free Safety | 56 | 1 | 4 | 33 | 2 | 44 | 22.0 | 1 |
| Kevin Byard III | OAK | Free Safety | 56 | 0 | 1 | 6 | 3 | 25 | 8.3 | 0 |
| Jalen Thompson | TTR | Strong Safety | 56 | 0 | 0 | 0 | 3 | 27 | 9.0 | 0 |
| Andrew Van Ginkel | JAC | Left O LB | 55 | 1 | 2 | 17 | 3 | 12 | 4.0 | 0 |
| George Odum | LAR | Safety | 55 | 0 | 2 | 13 | 1 | 20 | 20.0 | 0 |
| Tyrel Dodson | CAL | Left LB | 55 | 0 | 0 | 0 | 2 | 53 | 26.5 | 1 |
| Grover Stewart | WAS | Right Tackle | 55 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Jourdan Lewis | BUF | CB | 55 | 0 | 0 | 0 | 4 | 32 | 8.0 | 0 |
| Devonte Wyatt | LAC | Def Tackle | 54 | 2 | 8 | 31 | 0 | 0 | 0.0 | 0 |
| Ashtyn Davis | DAL | 1st Defensive Back | 54 | 1 | 1 | 8 | 0 | 0 | 0.0 | 0 |
| Darius Slay | SEA | Right CB | 54 | 0 | 0 | 0 | 3 | 13 | 4.3 | 0 |
| Cobie Durant | CAL | Left CB | 54 | 1 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Starling Thomas V | CLE | Right CB | 54 | 0 | 0 | 0 | 4 | 13 | 3.3 | 0 |
| Jessie Bates | CLE | Strong Safety | 54 | 0 | 0 | 0 | 7 | 32 | 4.6 | 0 |
| Bobby Okereke | WAS | Left I LB | 54 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Quinnen Williams | SCS | Right Tackle | 53 | 0 | 11 | 72 | 0 | 0 | 0.0 | 0 |
| Xavier Woods | SCS | Free Safety | 53 | 0 | 3 | 21 | 2 | 93 | 46.5 | 1 |
| Ed Oliver | GBP | Right Tackle | 53 | 1 | 3 | 23 | 0 | 0 | 0.0 | 0 |
| Jaylon Carlies | SCS | Left LB | 53 | 1 | 2 | 19 | 0 | 0 | 0.0 | 0 |
| Travis Jones | JAC | Nose Tackle | 53 | 1 | 1 | 5 | 1 | 12 | 12.0 | 0 |
| Christian Elliss | DET | Left I LB | 53 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Javon Bullard | BAL | Strong Safety | 52 | 0 | 0 | 0 | 2 | 24 | 12.0 | 0 |
| Tyson Campbell | OAK | Left CB | 51 | 0 | 1 | 11 | 6 | 37 | 6.2 | 0 |
| Kyzir White | SEA | Left I LB | 51 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0 |
| Jeremy Chinn | LAC | Strong Safety | 49 | 0 | 2 | 9 | 0 | 0 | 0.0 | 0 |
| Julian Blackmon | NYG | Free Safety | 49 | 0 | 0 | 0 | 2 | 16 | 8.0 | 0 |
| Kristian Fulton | TTR | Right CB | 49 | 0 | 0 | 0 | 2 | 10 | 5.0 | 0 |
| Jordan Davis | DAL | Nose Tackle | 48 | 2 | 3 | 0 | 0 | 0 | 0.0 | 0 |
| Ar'Darius Washington | BUF | Free Safety | 48 | 0 | 0 | 0 | 1 | 13 | 13.0 | 0 |
| Kwity Paye | JAC | Left End | 47 | 2 | 5 | 38 | 0 | 0 | 0.0 | 0 |
| Kayvon Thibodeaux | WAS | Right End | 47 | 1 | 3 | 24 | 1 | 0 | 0.0 | 0 |
| Byron Murphy II | NYG | Nose Tackle | 47 | 1 | 1 | 6 | 0 | 0 | 0.0 | 0 |
| Myles Garrett | CLE | Left End | 46 | 1 | 10 | 72 | 1 | 13 | 13.0 | 0 |
| Evan Williams | CHI | Safety | 46 | 0 | 1 | 0 | 1 | 0 | 0.0 | 0 |
| Vita Vea | TTR | Nose Tackle | 44 | 2 | 2 | 13 | 0 | 0 | 0.0 | 0 |
| Germaine Pratt | NYG | Middle LB | 44 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Roy Lopez | NOV | Nose Tackle | 43 | 0 | 4 | 24 | 1 | 0 | 0.0 | 0 |
| Keeanu Benton | CAL | Nose Tackle | 43 | 0 | 2 | 3 | 0 | 0 | 0.0 | 0 |
| Reed Blankenship | CAL | Free Safety | 43 | 1 | 0 | 0 | 5 | 24 | 4.8 | 0 |
| DaQuan Jones | BUF | Left Tackle | 42 | 1 | 7 | 34 | 0 | 0 | 0.0 | 0 |
| Derwin James | SHR | Strong Safety | 42 | 1 | 1 | 0 | 4 | 70 | 17.5 | 0 |
| Kingsley Enagbare | SCS | Left End | 42 | 1 | 1 | 4 | 0 | 0 | 0.0 | 0 |
| A.J. Epenesa | TTR | Right End | 41 | 1 | 5 | 44 | 0 | 0 | 0.0 | 0 |
| Zach Sieler | PHO | Right Tackle | 41 | 1 | 4 | 22 | 0 | 0 | 0.0 | 0 |
| Joey Bosa | PHI | Left End | 41 | 0 | 3 | 18 | 0 | 0 | 0.0 | 0 |
| D.J. Wonnum | NOV | Right O LB | 41 | 2 | 1 | 5 | 1 | 4 | 4.0 | 0 |
| Eric Murray | PHI | Free Safety | 41 | 0 | 1 | 2 | 5 | 14 | 2.8 | 0 |
| Will Anderson Jr. | CAL | Left End | 40 | 0 | 8 | 58 | 0 | 0 | 0.0 | 0 |
| Calais Campbell | BAL | Left End | 40 | 0 | 4 | 15 | 1 | 34 | 34.0 | 1 |
| D.J. Reader | BAL | Right Tackle | 39 | 0 | 6 | 26 | 0 | 0 | 0.0 | 0 |
| D.J. Jones | SEA | Nose Tackle | 39 | 0 | 4 | 11 | 0 | 0 | 0.0 | 0 |
| Xavier McKinney | SEA | Free Safety | 39 | 0 | 1 | 3 | 4 | 50 | 12.5 | 0 |
| Ivan Pace Jr. | PHI | Left I LB | 39 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0 |
| Harrison Phillips | NOS | Nose Tackle | 38 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0 |
| Emmanuel Ogbah | DAL | Right End | 38 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Josh Hines-Allen | LAC | Left End | 37 | 0 | 8 | 67 | 0 | 0 | 0.0 | 0 |
| Travon Walker | LAC | Right End | 37 | 0 | 7 | 51 | 0 | 0 | 0.0 | 0 |
| Bryan Bresee | LAR | Right Tackle | 37 | 0 | 5 | 31 | 0 | 0 | 0.0 | 0 |
| Alim McNeill | SHR | Left Tackle | 37 | 0 | 2 | 0 | 0 | 0 | 0.0 | 0 |
| Kamren Kinchens | GBP | Free Safety | 37 | 0 | 0 | 0 | 2 | 139 | 69.5 | 2 |
| Montez Sweat | OAK | Left End | 36 | 0 | 7 | 54 | 1 | 79 | 79.0 | 1 |
| Cameron Jordan | DET | Left End | 36 | 0 | 3 | 24 | 0 | 0 | 0.0 | 0 |
| Nathan Shepherd | SCS | Left Tackle | 36 | 0 | 2 | 0 | 0 | 0 | 0.0 | 0 |
| Darnell Savage | NOV | Free Safety | 36 | 0 | 0 | 0 | 2 | 12 | 6.0 | 0 |
| Trey Hendrickson | OAK | Right End | 35 | 1 | 10 | 74 | 0 | 0 | 0.0 | 0 |
| T.J. Slaton | MIS | Right Tackle | 35 | 1 | 4 | 20 | 0 | 0 | 0.0 | 0 |
| Tershawn Wharton | MIS | Left Tackle | 35 | 0 | 2 | 14 | 0 | 0 | 0.0 | 0 |
| DeForest Buckner | OAK | Left Tackle | 35 | 1 | 2 | 0 | 0 | 0 | 0.0 | 0 |
| Josh Paschal | CIN | Right End | 35 | 0 | 0 | 0 | 1 | 20 | 20.0 | 0 |
| Will McDonald IV | LAR | Left End | 33 | 1 | 10 | 57 | 0 | 0 | 0.0 | 0 |
| Logan Hall | CAL | Right End | 33 | 0 | 3 | 26 | 0 | 0 | 0.0 | 0 |
| Eddie Goldman | PHI | Nose Tackle | 33 | 1 | 1 | 0 | 0 | 0 | 0.0 | 0 |
| Amani Hooker | JAC | Strong Safety | 33 | 0 | 0 | 0 | 6 | 55 | 9.2 | 0 |
| Gervon Dexter Sr. | CIN | Right Tackle | 33 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Jonathan Allen | PHO | Right Tackle | 32 | 0 | 3 | 17 | 0 | 0 | 0.0 | 0 |
| Nick Bosa | CLE | Right End | 31 | 0 | 6 | 44 | 0 | 0 | 0.0 | 0 |
| George Karlaftis | NOV | Left End | 31 | 0 | 5 | 31 | 0 | 0 | 0.0 | 0 |
| Andru Phillips | PHI | CB | 31 | 0 | 0 | 0 | 1 | 12 | 12.0 | 0 |
| Za'Darius Smith | SEA | Left End | 30 | 0 | 7 | 58 | 0 | 0 | 0.0 | 0 |
| Adam Butler | LAR | Right Tackle | 30 | 0 | 6 | 36 | 0 | 0 | 0.0 | 0 |
| Chris Jones | WAS | Right Tackle | 30 | 0 | 4 | 24 | 0 | 0 | 0.0 | 0 |
| Micheal Clemons | NOS | Right End | 30 | 1 | 2 | 12 | 0 | 0 | 0.0 | 0 |
| Tyquan Lewis | SHR | Def End | 30 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Dante Stills | BUF | Left End | 29 | 1 | 2 | 16 | 0 | 0 | 0.0 | 0 |
| Daron Payne | OAK | Left Tackle | 29 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Garrett Williams | LAC | CB | 29 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Arron Mosby | MIS | Def End | 29 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Sam Hubbard | MIS | Left End | 28 | 0 | 2 | 8 | 0 | 0 | 0.0 | 0 |
| John Jenkins | BUF | Left Tackle | 28 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Laiatu Latu | LAR | Def End | 27 | 0 | 6 | 38 | 2 | 25 | 12.5 | 0 |
| DeShon Elliott | PHO | Strong Safety | 27 | 0 | 2 | 14 | 2 | 10 | 5.0 | 0 |
| Jalen Carter | BAL | Right End | 27 | 0 | 2 | 14 | 0 | 0 | 0.0 | 0 |
| Mazi Smith | CLE | Left Tackle | 27 | 0 | 1 | 8 | 1 | 4 | 4.0 | 0 |
| Cameron Heyward | SCS | Right End | 27 | 0 | 1 | 5 | 0 | 0 | 0.0 | 0 |
| Milton Williams | PHO | Left End | 27 | 1 | 1 | 11 | 0 | 0 | 0.0 | 0 |
| Rashan Gary | PHI | Right End | 26 | 0 | 8 | 60 | 0 | 0 | 0.0 | 0 |
| Antoine Winfield Jr. | BAL | Free Safety | 26 | 0 | 4 | 18 | 1 | 0 | 0.0 | 0 |
| Kenny Clark | GBP | Left Tackle | 26 | 0 | 1 | 0 | 1 | 4 | 4.0 | 0 |
| Tony Adams | NOS | Free Safety | 26 | 0 | 0 | 0 | 2 | 20 | 10.0 | 0 |
| B.J. Hill | BAL | Right Tackle | 25 | 0 | 2 | 15 | 0 | 0 | 0.0 | 0 |
| Sebastian Joseph-Day | BUF | Left End | 25 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Jonathan Greenard | SEA | Right O LB | 24 | 1 | 7 | 49 | 0 | 0 | 0.0 | 0 |
| Derek Barnett | NYG | Def End | 24 | 0 | 5 | 44 | 0 | 0 | 0.0 | 0 |
| Andrew Billings | SHR | Left Tackle | 24 | 1 | 2 | 6 | 0 | 0 | 0.0 | 0 |
| DeMarcus Walker | NOS | Right End | 24 | 1 | 1 | 10 | 0 | 0 | 0.0 | 0 |
| Zacch Pickens | CIN | Def Tackle | 24 | 1 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Larry Ogunjobi | CHI | Left End | 24 | 1 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Zach Allen | SHR | Left End | 23 | 0 | 7 | 47 | 0 | 0 | 0.0 | 0 |
| Kyler Gordon | NYG | CB | 23 | 0 | 0 | 0 | 1 | 13 | 13.0 | 0 |
| Nnamdi Madubuike | NYG | Left End | 22 | 2 | 2 | 17 | 0 | 0 | 0.0 | 0 |
| Carl Granderson | DAL | Right End | 21 | 0 | 1 | 12 | 1 | 25 | 25.0 | 0 |
| Leonard Williams | CHI | Right End | 20 | 0 | 3 | 28 | 0 | 0 | 0.0 | 0 |
| Nick Cross | DET | Strong Safety | 20 | 0 | 0 | 0 | 2 | 121 | 60.5 | 1 |
| Danielle Hunter | WAS | Right End | 19 | 0 | 8 | 42 | 0 | 0 | 0.0 | 0 |
| Jordan Elliott | CLE | Right Tackle | 19 | 1 | 1 | 4 | 0 | 0 | 0.0 | 0 |
| Leonard Floyd | PHO | Left End | 18 | 0 | 4 | 29 | 1 | 20 | 20.0 | 0 |
| Jonathan Owens | CAL | 1st Defensive Back | 18 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Tyree Wilson | JAC | Right End | 18 | 1 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Maxx Crosby | TTR | Left End | 17 | 1 | 4 | 26 | 0 | 0 | 0.0 | 0 |
| Greg Rousseau | NOV | Left End | 17 | 1 | 3 | 22 | 0 | 0 | 0.0 | 0 |
| Jeffery Simmons | DET | Right End | 17 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Riley Moss | SHR | Right CB | 17 | 0 | 0 | 0 | 2 | 15 | 7.5 | 0 |
| Kenny Moore II | NOV | CB | 16 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Daniel Ekuale | GBP | Right End | 15 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Jalen Pitre | CHI | CB | 15 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Elijah Molden | SEA | CB | 15 | 0 | 0 | 0 | 1 | 0 | 0.0 | 0 |
| Cooper DeJean | LAR | CB | 15 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Ji'Ayir Brown | NOS | Free Safety | 14 | 0 | 0 | 0 | 2 | 61 | 30.5 | 1 |
| Kamren Curl | CHI | Strong Safety | 13 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Braden Fiske | CIN | Left End | 13 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Jevon Holland | BUF | Free Safety | 13 | 0 | 0 | 0 | 1 | 0 | 0.0 | 0 |
| Marlon Humphrey | CLE | CB | 13 | 0 | 0 | 0 | 3 | 20 | 6.7 | 0 |
| Chamarri Conner | MIS | CB | 12 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Arik Armstead | GBP | Def End | 12 | 1 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Jimmie Ward | GBP | 1st Defensive Back | 11 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Mike Brown | SCS | Safety | 11 | 0 | 0 | 0 | 1 | 12 | 12.0 | 0 |
| Tommy Togiai | CLE | Def Tackle | 11 | 1 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Jonathan Bullard | GBP | Right End | 10 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Jake Martin | PHI | Def End | 9 | 0 | 2 | 12 | 0 | 0 | 0.0 | 0 |
| Clark Phillips III | CIN | CB | 9 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Nate Hobbs | DAL | CB | 9 | 0 | 0 | 0 | 1 | 0 | 0.0 | 0 |
| Will Harris | TTR | Strong Safety | 9 | 0 | 0 | 0 | 1 | 0 | 0.0 | 0 |
| Kool-Aid McKinstry | JAC | Left CB | 8 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| K'Lavon Chaisson | CHI | Def End | 7 | 0 | 2 | 12 | 0 | 0 | 0.0 | 0 |
| Tuli Tuipulotu | SHR | Right O LB | 7 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Darrell Baker Jr. | PHO | CB | 7 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Charles Snowden | NOV | Left LB | 6 | 1 | 1 | 10 | 0 | 0 | 0.0 | 0 |
| Cor'Dale Flott | PHI | Left CB | 6 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Ja'Quan McMillian | BAL | CB | 6 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Jalyn Armour-Davis | OAK | 1st Defensive Back | 5 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Sean Murphy-Bunting | WAS | Left CB | 5 | 0 | 0 | 0 | 1 | 25 | 25.0 | 0 |
| John Franklin-Myers | SCS | Right End | 4 | 0 | 1 | 7 | 0 | 0 | 0.0 | 0 |
| Dell Pettus | CIN | 1st Defensive Back | 4 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Bryce Huff | SHR | O LB | 3 | 0 | 2 | 12 | 0 | 0 | 0.0 | 0 |
| Chidobe Awuzie | DET | Left CB | 3 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Jonathon Cooper | BUF | Left O LB | 3 | 1 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Carl Lawson | GBP | Def End | 2 | 0 | 2 | 20 | 0 | 0 | 0.0 | 0 |
| Ugo Amadi | NOV | 1st Defensive Back | 2 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Jordan Whitehead | DAL | Strong Safety | 2 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Kyle Dugger | NOS | Strong Safety | 2 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Levi Wallace | LAR | CB | 2 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Jarrian Jones | SCS | CB | 2 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Josh Newton | WAS | Right CB | 2 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Nick Herbig | CHI | O LB | 1 | 0 | 1 | 9 | 0 | 0 | 0.0 | 0 |
| Maliek Collins | PHO | Left Tackle | 1 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Jordan Fuller | SCS | Strong Safety | 1 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Isaiah Oliver | CLE | CB | 1 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Yetur Gross-Matos | GBP | Def End | 1 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Terrel Bernard | MIS | Middle LB | 1 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Mike Pennel | BAL | Def Tackle | 1 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Damar Hamlin | TTR | Free Safety | 1 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Kris Abrams-Draine | OAK | 1st Defensive Back | 1 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Michael Carter II | SHR | 1st Defensive Back | 1 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Al-Quadin Muhammad | MIS | Def End | 1 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| David Onyemata | BAL | Right End | 1 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Azeez Al-Shaair | SEA | Right LB | 1 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Deommodore Lenoir | NYG | CB | 1 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Marcus Jones | JAC | CB | 1 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Bud Dupree | BAL | Def End | 1 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 |
| Sum | --- | --- | 17021 | 122 | 503 | 3048 | 297 | 3675 | 12.4 | 21 |
| Avg | --- | --- | 52 | 0 | 2 | 9 | 1 | 11 | 12.4 | 0 |