Player_Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Myles Garrett | DET | Left End | 16 | 125 |
| Trey Hendrickson | OKL | Right End | 16 | 121 |
| Brian Burns | LAC | Right O LB | 15 | 111 |
| Micah Parsons | NEP | Right End | 11 | 80 |
| Zach Sieler | STL | Right Tackle | 10 | 78 |
| Danielle Hunter | SEA | Right End | 10 | 73 |
| Kenneth Murray | OKL | Left I LB | 10 | 69 |
| Derick Hall | LAR | Right O LB | 10 | 69 |
| Nick Bosa | NOS | Right End | 9 | 76 |
| Will Anderson Jr. | LAR | Left End | 9 | 56 |
| Dalvin Tomlinson | POR | Left Tackle | 8 | 57 |
| Montez Sweat | OKL | Left End | 8 | 55 |
| Will McDonald IV | IND | Left End | 8 | 52 |
| Leonard Williams | CIN | Right End | 7 | 59 |
| Jeremiah Trotter Jr. | OKL | LB | 7 | 57 |
| Zach Allen | PHI | Left End | 7 | 55 |
| Za'Darius Smith | NOV | Left End | 7 | 53 |
| Arden Key | POR | Right O LB | 7 | 49 |
| Zaven Collins | LAC | Left O LB | 7 | 44 |
| Quinnen Williams | LAC | Right Tackle | 7 | 41 |
| T.J. Watt | SEA | Left O LB | 6 | 50 |
| DeMarvion Overshown | LAR | Left LB | 6 | 50 |
| Andrew Van Ginkel | ATL | Left O LB | 6 | 48 |
| Harold Landry | BUF | Left O LB | 6 | 45 |
| DeForest Buckner | CIN | Left Tackle | 6 | 43 |
| Shelby Harris | LAC | Right Tackle | 6 | 41 |
| Chris Jones | HOU | Right Tackle | 6 | 39 |
| Byron Young | IND | Right O LB | 6 | 35 |
| Cameron Heyward | SF4 | Right End | 6 | 35 |
| Tershawn Wharton | SEA | Left Tackle | 6 | 30 |
| Jonathan Greenard | POR | Right O LB | 5 | 36 |
| Micheal Clemons | LAC | Right End | 5 | 35 |
| Maxx Crosby | NEP | Left End | 5 | 34 |
| Nolan Smith | CIN | Right O LB | 5 | 32 |
| Tyrice Knight | DET | Left I LB | 5 | 13 |
| Jeremiah Ledbetter | MIN | Right Tackle | 5 | 10 |
| Kwity Paye | DET | Left End | 4 | 36 |
| Brandon Jones | PIT | Strong Safety | 4 | 35 |
| Vita Vea | ATL | Nose Tackle | 4 | 32 |
| Nik Bonitto | DET | Right O LB | 4 | 31 |
| Brandon Graham | PHO | O LB | 4 | 31 |
| Gervon Dexter Sr. | LAR | Right Tackle | 4 | 31 |
| Minkah Fitzpatrick | ATL | Free Safety | 4 | 30 |
| Nnamdi Madubuike | POR | Left End | 4 | 28 |
| Tyree Wilson | BUF | Right End | 4 | 27 |
| B.J. Hill | NOS | Right Tackle | 4 | 27 |
| Kyle Van Noy | PIT | Left O LB | 4 | 24 |
| Keion White | LAR | Right O LB | 4 | 24 |
| Dexter Lawrence | TTR | Nose Tackle | 4 | 23 |
| Michael Hall Jr. | SF4 | Def Tackle | 4 | 22 |
| Alex Highsmith | NEP | Right O LB | 4 | 21 |
| Nick Cross | LAR | Strong Safety | 4 | 16 |
| Byron Murphy II | DET | Nose Tackle | 4 | 8 |
| Tavius Robinson | DET | Right O LB | 3 | 33 |
| Joey Bosa | TTR | Left End | 3 | 32 |
| Mike Danna | HOU | Right End | 3 | 29 |
| Devin Lloyd | LAC | Middle LB | 3 | 25 |
| Rashan Gary | STL | Right End | 3 | 24 |
| Daron Payne | OKL | Left Tackle | 3 | 23 |
| Isaiah Rodgers | SCS | 1st Defensive Back | 3 | 23 |
| Budda Baker | POR | Free Safety | 3 | 23 |
| Josh Sweat | IND | Left O LB | 3 | 22 |
| Jonathan Allen | OKL | Right Tackle | 3 | 22 |
| Nakobe Dean | STL | Right I LB | 3 | 21 |
| Chop Robinson | LAR | Def End | 3 | 20 |
| Travis Jones | LAR | Nose Tackle | 3 | 20 |
| Jalen Thompson | PHI | Strong Safety | 3 | 19 |
| Frankie Luvu | PHI | Right LB | 3 | 18 |
| Eric Kendricks | CIN | Middle LB | 3 | 14 |
| Grover Stewart | CIN | Right Tackle | 3 | 13 |
| Michael Pierce | SF4 | Def Tackle | 3 | 13 |
| D.J. Reader | POR | Right Tackle | 3 | 12 |
| T'Vondre Sweat | NEP | Nose Tackle | 3 | 5 |
| Jarran Reed | NYG | Left End | 2 | 21 |
| Josh Hines-Allen | NOS | Left End | 2 | 20 |
| Travon Walker | CIN | Right End | 2 | 19 |
| Boye Mafe | NOS | Left O LB | 2 | 17 |
| Grady Jarrett | SF4 | Left End | 2 | 16 |
| Payton Wilson | OKL | LB | 2 | 16 |
| Kobie Turner | IND | Right End | 2 | 14 |
| Alim McNeill | KEN | Left Tackle | 2 | 14 |
| Calijah Kancey | ATL | Left End | 2 | 13 |
| Derek Barnett | SEA | Def End | 2 | 13 |
| Milton Williams | KEN | Left End | 2 | 12 |
| Dee Winters | STL | Left LB | 2 | 11 |
| Taylor Rapp | LAC | Strong Safety | 2 | 9 |
| Clelin Ferrell | NYG | Left End | 2 | 9 |
| Emmanuel Ogbah | PIT | Right End | 2 | 9 |
| Cody Barton | BUF | Right I LB | 2 | 6 |
| Bobby Okereke | TTR | Left I LB | 2 | 6 |
| Michael Hoecht | LAR | LB | 2 | 5 |
| Mazi Smith | NOV | Left Tackle | 2 | 5 |
| Zack Baun | IND | Left I LB | 2 | 3 |
| Denzel Perryman | HOU | Right I LB | 2 | 2 |
| Daiyan Henley | LAR | Left I LB | 2 | 2 |
| Keeanu Benton | PIT | Nose Tackle | 2 | 0 |
| Bobby Wagner | NYG | Middle LB | 2 | 0 |
| Jamien Sherwood | HOU | Middle LB | 2 | 0 |
| Sam Kamara | MIN | Def Tackle | 2 | 0 |
| Dante Stills | NOV | Left End | 1 | 12 |
| Jordan Poyer | TTR | Strong Safety | 1 | 12 |
| Sam Hubbard | NEP | Left End | 1 | 12 |
| Malcolm Rodriguez | SF4 | Right LB | 1 | 11 |
| Alex Anzalone | NOV | Left LB | 1 | 11 |
| DeMarcus Walker | BUF | Right End | 1 | 11 |
| Dante Fowler | PIT | Left LB | 1 | 10 |
| Jimmie Ward | DET | 1st Defensive Back | 1 | 10 |
| A.J. Terrell | DET | Right CB | 1 | 9 |
| Jartavius Martin | LAR | Free Safety | 1 | 9 |
| Dayo Odeyingbo | HOU | Right End | 1 | 9 |
| DaVon Hamilton | NOS | Left Tackle | 1 | 9 |
| Leonard Floyd | OKL | Left End | 1 | 8 |
| Tarheeb Still | STL | Left CB | 1 | 8 |
| Pete Werner | NOS | Right LB | 1 | 8 |
| Carl Granderson | STL | Right End | 1 | 8 |
| Poona Ford | PIT | Right End | 1 | 8 |
| Maason Smith | NOV | Def Tackle | 1 | 7 |
| Jalen Carter | ATL | Right End | 1 | 7 |
| Calais Campbell | ATL | Left End | 1 | 7 |
| Coby Bryant | STL | Strong Safety | 1 | 7 |
| Patrick Queen | NOS | Left I LB | 1 | 7 |
| Tyquan Lewis | KEN | Def End | 1 | 6 |
| Jeffery Simmons | POR | Right End | 1 | 6 |
| D.J. Wonnum | HOU | Right O LB | 1 | 6 |
| Amani Hooker | DET | Strong Safety | 1 | 6 |
| Mike Pennel | PHO | Def Tackle | 1 | 6 |
| Dallas Turner | ATL | O LB | 1 | 6 |
| Isaiah Pola-Mao | BUF | Strong Safety | 1 | 5 |
| Jalen Ramsey | SEA | Right CB | 1 | 5 |
| Jonathon Cooper | SCS | Left O LB | 1 | 5 |
| Nate Landman | ATL | Left I LB | 1 | 4 |
| Fred Warner | ATL | Middle LB | 1 | 4 |
| Edgerrin Cooper | NEP | LB | 1 | 3 |
| Elijah Garcia | PHO | Def Tackle | 1 | 3 |
| Kamren Curl | SF4 | Strong Safety | 1 | 2 |
| Jeremy Chinn | CIN | Strong Safety | 1 | 2 |
| Terrel Bernard | PIT | Middle LB | 1 | 1 |
| Jack Gibbens | TTR | I LB | 1 | 1 |
| Otito Ogbonnia | NYG | Nose Tackle | 1 | 0 |
| Harrison Phillips | PHO | Nose Tackle | 1 | 0 |
| Ivan Pace Jr. | IND | Left I LB | 1 | 0 |
| Josey Jewell | SF4 | Right I LB | 1 | 0 |
| Christian Elliss | PIT | Left I LB | 1 | 0 |
| Elandon Roberts | PHO | Right I LB | 1 | 0 |
| Sum | --- | --- | 504 | 3326 |
| Avg | --- | --- | 4 | 23 |