Player_Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Arden Key | TBB | Right O LB | 20 | 137 |
| Derick Hall | HOU | Right O LB | 18 | 150 |
| Tuli Tuipulotu | LAC | Right O LB | 17 | 99 |
| Quinnen Williams | OAK | Right Tackle | 16 | 61 |
| Micah Parsons | SLC | Right End | 13 | 85 |
| T.J. Watt | ATL | Left O LB | 12 | 83 |
| Calijah Kancey | NYG | Left End | 12 | 75 |
| Maxx Crosby | LAC | Left End | 11 | 76 |
| Keion White | HOU | Right O LB | 11 | 76 |
| Dexter Lawrence | GRR | Nose Tackle | 11 | 65 |
| Jonathan Greenard | NYJ | Right O LB | 9 | 78 |
| Zach Sieler | OKL | Right Tackle | 9 | 74 |
| Myles Garrett | STL | Left End | 9 | 69 |
| Nakobe Dean | SLC | Right I LB | 9 | 40 |
| Joey Bosa | LAR | Left End | 8 | 61 |
| Karl Brooks | CAR | Def End | 7 | 56 |
| Kwity Paye | MON | Left End | 7 | 51 |
| Travon Walker | CLE | Right End | 7 | 49 |
| Micheal Clemons | HOU | Right End | 7 | 45 |
| DeForest Buckner | MON | Left Tackle | 6 | 56 |
| Brian Burns | CAR | Right O LB | 6 | 51 |
| Nick Bosa | CLE | Right End | 6 | 50 |
| Will McDonald IV | ATL | Left End | 6 | 44 |
| Leonard Williams | HOO | Right End | 6 | 43 |
| Chris Jones | SLC | Right Tackle | 6 | 43 |
| Kobie Turner | TBB | Right End | 6 | 41 |
| Otito Ogbonnia | HOU | Nose Tackle | 6 | 37 |
| B.J. Hill | CLE | Right Tackle | 6 | 36 |
| Harold Landry | DET | Left O LB | 6 | 34 |
| Logan Hall | DAL | Right End | 6 | 26 |
| Gervon Dexter Sr. | BUF | Right Tackle | 6 | 20 |
| Jonathan Allen | LAC | Right Tackle | 6 | 19 |
| Michael Hoecht | OAK | LB | 5 | 40 |
| Clelin Ferrell | OAK | Left End | 5 | 40 |
| Za'Darius Smith | SEA | Left End | 5 | 39 |
| Jeremy Chinn | OAK | Strong Safety | 5 | 37 |
| Daron Payne | DET | Left Tackle | 5 | 37 |
| Andrew Van Ginkel | HOO | Left O LB | 5 | 37 |
| Dante Fowler | NOV | Left LB | 5 | 35 |
| Cameron Jordan | PHI | Left End | 5 | 35 |
| Dorance Armstrong | DAL | Right End | 5 | 28 |
| Vita Vea | TBB | Nose Tackle | 5 | 26 |
| Quay Walker | GRR | Middle LB | 5 | 10 |
| Kenneth Murray | GRR | Left I LB | 4 | 36 |
| Tyree Wilson | TBB | Right End | 4 | 36 |
| Nnamdi Madubuike | GRR | Left End | 4 | 34 |
| Jonathon Cooper | HAM | Left O LB | 4 | 33 |
| Danielle Hunter | BUF | Right End | 4 | 31 |
| Will Anderson Jr. | PHS | Left End | 4 | 31 |
| Jadeveon Clowney | DET | Left O LB | 4 | 29 |
| Cameron Heyward | HOO | Right End | 4 | 27 |
| Josh Hines-Allen | CIN | Left End | 4 | 25 |
| Carl Granderson | SHR | Right End | 4 | 22 |
| Jamien Sherwood | HAM | Middle LB | 4 | 12 |
| T'Vondre Sweat | DAL | Nose Tackle | 4 | 11 |
| Kyzir White | PHS | Left I LB | 4 | 10 |
| Zack Baun | DET | Left I LB | 4 | 6 |
| Tershawn Wharton | NOS | Left Tackle | 3 | 32 |
| Nolan Smith | OAK | Right O LB | 3 | 29 |
| Jalen Carter | HOU | Right End | 3 | 27 |
| Nick Cross | CAR | Strong Safety | 3 | 26 |
| Ogbonnia Okoronkwo | STL | Def End | 3 | 25 |
| Chris Williams | HAM | Def End | 3 | 23 |
| Calais Campbell | DET | Left End | 3 | 22 |
| Greg Rousseau | SHR | Left End | 3 | 22 |
| Charles Snowden | BUF | Left LB | 3 | 22 |
| K'Lavon Chaisson | CAR | Def End | 3 | 20 |
| Shelby Harris | SLC | Right Tackle | 3 | 20 |
| Odafe Oweh | CAR | O LB | 3 | 20 |
| Julian Blackmon | HOU | Free Safety | 3 | 19 |
| Zach Allen | NYG | Left End | 3 | 19 |
| Mike Danna | LAR | Right End | 3 | 16 |
| Josh Sweat | DAL | Left O LB | 3 | 16 |
| Henry To'o To'o | DAL | Middle LB | 3 | 16 |
| Byron Young | PHO | Right O LB | 3 | 16 |
| Anfernee Jennings | PHO | Left O LB | 3 | 15 |
| Travis Jones | PHS | Nose Tackle | 3 | 11 |
| Ed Oliver | NOV | Right Tackle | 3 | 9 |
| Eddie Goldman | PHI | Nose Tackle | 3 | 6 |
| Roquan Smith | CAR | Left I LB | 3 | 5 |
| Bobby Wagner | SEA | Middle LB | 3 | 4 |
| Dondrea Tillman | PHI | O LB | 2 | 22 |
| Frankie Luvu | OKL | Right LB | 2 | 20 |
| Khalil Mack | HOO | Left O LB | 2 | 19 |
| Kyle Van Noy | CLE | Left O LB | 2 | 19 |
| Jesse Luketa | OAK | Right O LB | 2 | 19 |
| Javon Bullard | PHO | Strong Safety | 2 | 17 |
| Rashan Gary | PHS | Right End | 2 | 17 |
| Kingsley Enagbare | GRR | Left End | 2 | 16 |
| DeMarvion Overshown | DAL | Left LB | 2 | 16 |
| Jessie Bates | GRR | Strong Safety | 2 | 15 |
| Tremaine Edmunds | BUF | Middle LB | 2 | 15 |
| Andrew Billings | CIN | Left Tackle | 2 | 15 |
| Grady Jarrett | SCS | Left End | 2 | 14 |
| Trey Hendrickson | BUF | Right End | 2 | 14 |
| Brandon Graham | SLC | O LB | 2 | 14 |
| Grover Stewart | LAR | Right Tackle | 2 | 13 |
| Jeremiah Ledbetter | NYJ | Right Tackle | 2 | 13 |
| Xavier Woods | DAL | Free Safety | 2 | 13 |
| Tavius Robinson | SLC | Right O LB | 2 | 13 |
| Quincy Williams | NEP | Left LB | 2 | 12 |
| T.J. Edwards | NOV | Right LB | 2 | 12 |
| Denico Autry | SCS | Def End | 2 | 12 |
| Kamren Kinchens | SHR | Free Safety | 2 | 12 |
| Jared Verse | LAR | Left O LB | 2 | 11 |
| DeMarcus Walker | CIN | Right End | 2 | 11 |
| Matthew Judon | LAR | Right O LB | 2 | 11 |
| Neville Hewitt | GRR | Left LB | 2 | 10 |
| Cody Barton | HOU | Right I LB | 2 | 10 |
| Dre'Mont Jones | GRR | O LB | 2 | 10 |
| Braden Fiske | PHO | Left End | 2 | 9 |
| DaQuan Jones | NYJ | Left Tackle | 2 | 9 |
| John Jenkins | STL | Left Tackle | 2 | 9 |
| Harrison Phillips | NYG | Nose Tackle | 2 | 6 |
| Christian Rozeboom | TBB | Left I LB | 2 | 5 |
| Bryan Cook | NYG | Free Safety | 2 | 5 |
| Davon Godchaux | PHO | Nose Tackle | 2 | 5 |
| Montez Sweat | NEP | Left End | 2 | 4 |
| Troy Dye | STL | LB | 2 | 0 |
| Jordyn Brooks | ATL | Right LB | 1 | 13 |
| Jordan Davis | SEA | Nose Tackle | 1 | 12 |
| Daniel Ekuale | NOV | Right End | 1 | 12 |
| Trevor Nowaske | NYG | LB | 1 | 12 |
| Amani Hooker | HOO | Strong Safety | 1 | 11 |
| Deatrich Wise Jr. | NYJ | Left End | 1 | 11 |
| Tony Adams | ATL | Free Safety | 1 | 10 |
| Eric Kendricks | SCS | Middle LB | 1 | 10 |
| Zach Cunningham | MON | I LB | 1 | 10 |
| Jordan Fuller | ATL | Strong Safety | 1 | 9 |
| Leonard Floyd | PHO | Left End | 1 | 9 |
| Emmanuel Ogbah | NOV | Right End | 1 | 9 |
| Jordan Hicks | HAM | Middle LB | 1 | 8 |
| Jordan Howden | NYG | Safety | 1 | 8 |
| Jack Gibbens | NEP | I LB | 1 | 8 |
| Juan Thornhill | SLC | Free Safety | 1 | 8 |
| Jordan Poyer | SLC | Strong Safety | 1 | 8 |
| Kamari Lassiter | BUF | Right CB | 1 | 8 |
| Benjamin St-Juste | LAC | Left CB | 1 | 8 |
| DeShon Elliott | STL | Strong Safety | 1 | 7 |
| David Onyemata | PHI | Right End | 1 | 7 |
| Joey Porter Jr. | BUF | Right CB | 1 | 7 |
| Devonte Wyatt | STL | Def Tackle | 1 | 7 |
| Deonte Banks | PHS | Right CB | 1 | 7 |
| Leo Chenal | TBB | Left LB | 1 | 7 |
| Jeffery Simmons | DET | Right End | 1 | 6 |
| Zaven Collins | STL | Left O LB | 1 | 6 |
| Eric Wilson | SEA | Right LB | 1 | 6 |
| Jack Sanborn | CIN | Left LB | 1 | 6 |
| Maliek Collins | PHO | Left Tackle | 1 | 6 |
| Boye Mafe | NEP | Left O LB | 1 | 6 |
| Jaylon Carlies | SLC | Left LB | 1 | 5 |
| Christian Elliss | ATL | Left I LB | 1 | 5 |
| Kendall Fuller | HOO | Left CB | 1 | 5 |
| D.J. Reader | BUF | Right Tackle | 1 | 5 |
| Oren Burks | SHR | LB | 1 | 5 |
| Elandon Roberts | NYJ | Right I LB | 1 | 5 |
| Nik Bonitto | PHS | Right O LB | 1 | 5 |
| Derek Barnett | OAK | Def End | 1 | 5 |
| Jonah Elliss | STL | O LB | 1 | 5 |
| Zaire Franklin | LAC | Middle LB | 1 | 4 |
| Sam Kamara | HAM | Def Tackle | 1 | 4 |
| Dante Stills | OKL | Left End | 1 | 4 |
| Michael Jackson Sr. | NYJ | Left CB | 1 | 4 |
| Malcolm Rodriguez | SEA | Right LB | 1 | 4 |
| Von Miller | SLC | Def End | 1 | 4 |
| Jerome Baker | OKL | Right I LB | 1 | 4 |
| Julian Love | GRR | Free Safety | 1 | 3 |
| Mike Pennel | SCS | Def Tackle | 1 | 3 |
| Ar'Darius Washington | SEA | Free Safety | 1 | 3 |
| Payton Wilson | LAR | LB | 1 | 2 |
| Isaiah McGuire | LAC | Right End | 1 | 1 |
| Shy Tuttle | HOO | Nose Tackle | 1 | 1 |
| Isaiah Pola-Mao | STL | Strong Safety | 1 | 0 |
| Isaiah McDuffie | NYJ | Left LB | 1 | 0 |
| Byron Murphy II | NEP | Nose Tackle | 1 | 0 |
| Ivan Pace Jr. | DAL | Left I LB | 1 | 0 |
| Demario Davis | HOO | Middle LB | 1 | 0 |
| Jordan Elliott | SHR | Right Tackle | 1 | 0 |
| Nick Bolton | CLE | Middle LB | 1 | 0 |
| Jack Campbell | LAC | Middle LB | 1 | 0 |
| Sum | --- | --- | 611 | 3892 |
| Avg | --- | --- | 3 | 22 |