| League Record Book | |||||
| Passing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Completions | Jared Goff - New Orleans-NOV | Washington | 9/25/2022 | Washington 30-23 | 35 |
| Most Passing Yards | Patrick Mahomes - Oakland | Los Angeles-LAR | 10/30/2022 | Oakland 24-14 | 448 |
| Best Avg Yards Per Pass | Geno Smith - Seattle | Texas Tech | 11/13/2022 | Seattle 52-20 | 12.4 |
| Longest Completion | Joe Burrow - New York | Cleveland | 10/2/2022 | New York 24-17 | 86 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Completions | Los Angeles-LAC | Shreveport | 10/30/2022 | Shreveport 27-20 | 36 |
| Most Passing Yards | Oakland | Los Angeles-LAR | 10/30/2022 | Oakland 24-14 | 448 |
| Best Avg Yards Per Pass | Seattle | Texas Tech | 11/13/2022 | Seattle 52-20 | 12.4 |
| Longest Completion | New York | Cleveland | 10/2/2022 | New York 24-17 | 86 |
| Rushing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Carries | Nick Chubb - Chicago | Jacksonville | 12/25/2022 | Jacksonville 24-17 | 37 |
| Most Rushing Yards | Nick Chubb - Chicago | Buffalo | 11/20/2022 | Chicago 42-28 | 250 |
| Best Rushing Avg | Christian McCaffrey - Southern California | Philadelphia | 9/25/2022 | Southern California 30-11 | 11.0 |
| Longest Carry | Khalil Herbert - Green Bay | Southern California | 10/30/2022 | Southern California 47-28 | 83 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Carries | New Orleans-NOV | Los Angeles-LAR | 12/11/2022 | New Orleans-NOV 31-6 | 45 |
| Most Rushing Yards | New Orleans-NOV | Los Angeles-LAR | 12/11/2022 | New Orleans-NOV 31-6 | 284 |
| Best Rushing Avg | Jacksonville | San Francisco | 9/11/2022 | San Francisco 23-14 | 9.3 |
| Longest Carry | Green Bay | Southern California | 10/30/2022 | Southern California 47-28 | 83 |
| Receiving Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Receptions | T.J. Hockenson - New Orleans-NOV | Washington | 9/25/2022 | Washington 30-23 | 16 |
| Most Receiving Yards | D.J. Moore - New Orleans-NOV | Shreveport | 11/13/2022 | Shreveport 48-42 | 214 |
| Best Reception Yardage Avg | D.J. Moore - New Orleans-NOV | New Orleans-NOS | 11/27/2022 | New Orleans-NOS 40-37 | 32.0 |
| Longest Reception | Terrace Marshall Jr. - New York | Cleveland | 10/2/2022 | New York 24-17 | 86 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Receptions | Los Angeles-LAC | Shreveport | 10/30/2022 | Shreveport 27-20 | 36 |
| Most Receiving Yards | Oakland | Los Angeles-LAR | 10/30/2022 | Oakland 24-14 | 448 |
| Best Reception Yardage Avg | Seattle | Los Angeles-LAC | 9/25/2022 | Seattle 29-19 | 20.5 |
| Longest Reception | New York | Cleveland | 10/2/2022 | New York 24-17 | 86 |
| Kickoff Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Chris Evans - Green Bay | Southern California | 10/30/2022 | Southern California 47-28 | 7 |
| Best Return Yardage Avg | Kene Nwangwu - Washington | New York | 10/23/2022 | Washington 34-20 | 97.0 |
| Longest Return | Kene Nwangwu - Washington | New York | 10/23/2022 | Washington 34-20 | 97 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | Washington | Oakland | 10/9/2022 | Oakland 37-13 | 7 |
| Best Return Yardage Avg | Washington | New York | 10/23/2022 | Washington 34-20 | 97.0 |
| Longest Return | Washington | New York | 10/23/2022 | Washington 34-20 | 97 |
| Punt Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Marcus Jones - Jacksonville | Baltimore | 9/25/2022 | Jacksonville 37-23 | 5 |
| Best Return Yardage Avg | Avery Williams - Detroit | Texas Tech | 9/18/2022 | Texas Tech 30-27 | 56.0 |
| Longest Return | Marcus Jones - Jacksonville | Baltimore | 9/25/2022 | Jacksonville 37-23 | 80 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | Jacksonville | Baltimore | 9/25/2022 | Jacksonville 37-23 | 5 |
| Best Return Yardage Avg | Detroit | Texas Tech | 9/18/2022 | Texas Tech 30-27 | 56.0 |
| Longest Return | Jacksonville | Baltimore | 9/25/2022 | Jacksonville 37-23 | 80 |
| Defense Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Tackles | Bobby Wagner - Seattle | Dallas | 9/11/2022 | Seattle 31-24 | 17 |
| Sacks | Haason Reddick - Los Angeles-LAC | Detroit | 10/23/2022 | Los Angeles-LAC 25-9 | 4 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Tackles | Jacksonville | Detroit | 10/30/2022 | Jacksonville 16-13 | 63 |
| Sacks | Detroit | Los Angeles-LAC | 12/18/2022 | Detroit 17-6 | 8 |
| Interception Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Interceptions | Jaycee Horn - Dallas | Texas Tech | 9/25/2022 | Dallas 37-9 | 3 |
| Best Interception Yardage Avg | Rock Ya-Sin - Cleveland | Shreveport | 12/4/2022 | Cleveland 27-20 | 93.0 |
| Longest Interception | Rock Ya-Sin - Cleveland | Shreveport | 12/4/2022 | Cleveland 27-20 | 93 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Interceptions | Missouri | Baltimore | 10/16/2022 | Missouri 51-21 | 6 |
| Best Interception Yardage Avg | Cleveland | Shreveport | 12/4/2022 | Cleveland 27-20 | 93.0 |
| Longest Interception | Cleveland | Shreveport | 12/4/2022 | Cleveland 27-20 | 93 |