Player_Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Haason Reddick | LAC | Left LB | 21 | 159 |
| Myles Garrett | CLE | Right End | 15 | 120 |
| Chris Jones | WAS | Left Tackle | 12 | 92 |
| Brandon Graham | BAC | Def End | 11 | 88 |
| Dexter Lawrence | CHI | Nose Tackle | 11 | 70 |
| Nick Bosa | CLE | Left End | 10 | 74 |
| Javon Hargrave | SF4 | Right Tackle | 10 | 57 |
| Quinnen Williams | SCS | Right Tackle | 10 | 52 |
| Melvin Ingram III | LAR | O LB | 9 | 73 |
| Cameron Jordan | DET | Left End | 9 | 65 |
| Carl Lawson | LAC | Right End | 9 | 60 |
| Bobby Wagner | SEA | Left I LB | 9 | 45 |
| Alex Highsmith | DET | Right O LB | 8 | 70 |
| Leonard Floyd | PHO | Left O LB | 8 | 57 |
| Danielle Hunter | WAS | Left O LB | 7 | 61 |
| Bradley Chubb | WAS | Right O LB | 7 | 54 |
| P.J. Williams | LAR | Safety | 7 | 54 |
| Matt Judon | NOS | Right O LB | 7 | 49 |
| Josh Sweat | DET | Right End | 7 | 47 |
| Ndamukong Suh | LAR | Def Tackle | 7 | 46 |
| Brian Burns | DAL | Right End | 7 | 43 |
| DeForest Buckner | OAK | Left Tackle | 7 | 34 |
| Khalil Mack | CHI | Right O LB | 6 | 52 |
| Montez Sweat | OAK | Right End | 6 | 49 |
| Von Miller | WAS | Left LB | 6 | 48 |
| Jerry Hughes | SHR | Left End | 6 | 48 |
| Fletcher Cox | LAC | Left End | 6 | 47 |
| Jaelan Phillips | CLE | Left O LB | 6 | 44 |
| Rashan Gary | LAR | Left O LB | 6 | 43 |
| George Karlaftis | NOV | Left End | 6 | 43 |
| Jonathan Allen | SF4 | Right Tackle | 6 | 32 |
| J.J. Watt | DAL | Left End | 5 | 47 |
| Maxx Crosby | TTR | Left End | 5 | 45 |
| Baron Browning | CLE | Right O LB | 5 | 42 |
| Sam Hubbard | MIS | Left O LB | 5 | 40 |
| Kwity Paye | JAC | Left End | 5 | 38 |
| Kenny Clark | GBP | Nose Tackle | 5 | 35 |
| Greg Gaines | PHI | Nose Tackle | 5 | 25 |
| Ed Oliver | NYG | Right Tackle | 5 | 25 |
| Daron Payne | OAK | Left Tackle | 5 | 24 |
| Sheldon Rankins | JAC | Left Tackle | 5 | 23 |
| Harrison Phillips | NOS | Nose Tackle | 5 | 15 |
| Marcus Davenport | CHI | Right End | 4 | 36 |
| Ogbonnia Okoronkwo | SF4 | Right End | 4 | 34 |
| Trey Hendrickson | OAK | Right O LB | 4 | 34 |
| Drue Tranquill | CLE | Left I LB | 4 | 33 |
| Markus Golden | DAL | Left O LB | 4 | 32 |
| Justin Madubuike | NYG | Right End | 4 | 31 |
| Aaron Donald | PHO | Right End | 4 | 31 |
| James Houston IV | SEA | O LB | 4 | 29 |
| Minkah Fitzpatrick | MIS | Free Safety | 4 | 27 |
| Davon Godchaux | PHO | Nose Tackle | 4 | 26 |
| Taylor Rapp | GBP | Strong Safety | 4 | 26 |
| Jadeveon Clowney | MIS | Left End | 4 | 25 |
| Vita Vea | TTR | Nose Tackle | 4 | 18 |
| Sebastian Joseph-Day | BUF | Nose Tackle | 4 | 9 |
| Julian Love | NYG | Strong Safety | 3 | 28 |
| Joey Bosa | PHI | Left End | 3 | 28 |
| Aidan Hutchinson | MIS | Left End | 3 | 27 |
| Zach Sieler | PHO | Right End | 3 | 25 |
| Marcus Epps | SHR | Free Safety | 3 | 25 |
| Efe Obada | SEA | Def End | 3 | 23 |
| Calais Campbell | BAC | Left End | 3 | 22 |
| Darrell Taylor | DAL | O LB | 3 | 22 |
| Mario Edwards Jr. | WAS | Left O LB | 3 | 20 |
| Shaq Thompson | OAK | Middle LB | 3 | 19 |
| DeMarcus Lawrence | JAC | Left End | 3 | 18 |
| Preston Smith | BAC | Right O LB | 3 | 18 |
| Anthony Nelson | NYG | O LB | 3 | 17 |
| Justin Houston | SHR | O LB | 3 | 16 |
| Leki Fotu | SEA | Nose Tackle | 3 | 16 |
| Uchenna Nwosu | BAC | Left O LB | 3 | 16 |
| Quay Walker | CHI | Right I LB | 3 | 13 |
| C.J. Mosley | DAL | Middle LB | 3 | 12 |
| Al Woods | LAC | Nose Tackle | 3 | 12 |
| Germaine Pratt | NYG | Right I LB | 3 | 11 |
| Zachary Carter | NYG | Right End | 2 | 24 |
| Joe Tryon-Shoyinka | SF4 | Right O LB | 2 | 18 |
| Denico Autry | NOS | Right End | 2 | 18 |
| Talanoa Hufanga | SEA | Strong Safety | 2 | 17 |
| Grady Jarrett | SEA | Right End | 2 | 16 |
| Matt Milano | SF4 | Right LB | 2 | 15 |
| John Franklin-Myers | SCS | Left End | 2 | 15 |
| Yannick Ngakoue | CAL | Right End | 2 | 15 |
| Dorance Armstrong | NOS | Right End | 2 | 14 |
| DeShon Elliott | PHO | Strong Safety | 2 | 14 |
| Josh Allen | LAC | Right O LB | 2 | 13 |
| Micah Parsons | OAK | Right LB | 2 | 13 |
| Josh Uche | NOV | O LB | 2 | 13 |
| Nick Bolton | NOV | Middle LB | 2 | 11 |
| Kevin Byard | OAK | Free Safety | 2 | 11 |
| Demario Davis | SF4 | Middle LB | 2 | 8 |
| Andrew Billings | SHR | Left Tackle | 2 | 8 |
| Justin Simmons | CHI | Strong Safety | 2 | 8 |
| DaVon Hamilton | CAL | Nose Tackle | 2 | 6 |
| D.J. Reader | BAC | Nose Tackle | 2 | 6 |
| Jonathan Bostic | GBP | Middle LB | 2 | 2 |
| Duke Riley | SCS | I LB | 2 | 1 |
| T.J. Edwards | NOS | Middle LB | 2 | 1 |
| David Long | CAL | Left I LB | 2 | 0 |
| Khyiris Tonga | CLE | Def Tackle | 2 | 0 |
| Frank Clark | SF4 | Right End | 1 | 14 |
| Trevis Gipson | LAR | Left End | 1 | 14 |
| Jeffery Simmons | DET | Left End | 1 | 13 |
| Shy Tuttle | NOV | Left Tackle | 1 | 12 |
| Anfernee Jennings | SHR | O LB | 1 | 12 |
| Kendall Fuller | SCS | Right CB | 1 | 11 |
| Quinton Jefferson | SHR | Def Tackle | 1 | 11 |
| Leonard Williams | CHI | Right End | 1 | 10 |
| Alex Wright | LAR | Def End | 1 | 10 |
| James Smith-Williams | TTR | Left End | 1 | 10 |
| Roquan Smith | BUF | Right I LB | 1 | 10 |
| Isaiah Rodgers | SCS | Left CB | 1 | 9 |
| Jaycee Horn | DAL | Right CB | 1 | 9 |
| Travon Walker | LAC | Left O LB | 1 | 9 |
| Greg Rousseau | NOV | Left End | 1 | 9 |
| Darrick Forrest | TTR | Free Safety | 1 | 8 |
| Kenneth Murray | LAC | Right I LB | 1 | 8 |
| Budda Baker | LAC | Strong Safety | 1 | 8 |
| Kaden Elliss | CAL | Left LB | 1 | 8 |
| Rock Ya-Sin | CLE | Left CB | 1 | 7 |
| Christian Wilkins | JAC | Left End | 1 | 7 |
| Carlton Davis | DET | Left CB | 1 | 7 |
| Dayo Odeyingbo | SEA | Def End | 1 | 7 |
| Cameron Heyward | SCS | Right End | 1 | 7 |
| Alex Singleton | NOS | Right I LB | 1 | 6 |
| Isaiah Simmons | OAK | Right O LB | 1 | 6 |
| Roy Robertson-Harri | CAL | Right End | 1 | 6 |
| Michael Hoecht | MIS | Right O LB | 1 | 5 |
| Kurt Hinish | DET | Def Tackle | 1 | 5 |
| Chidobe Awuzie | SF4 | Left CB | 1 | 5 |
| Teair Tart | DET | Nose Tackle | 1 | 4 |
| Juan Thornhill | PHI | Free Safety | 1 | 4 |
| E.J. Speed | LAC | LB | 1 | 4 |
| Bobby McCain | CLE | Strong Safety | 1 | 3 |
| Shaquil Barrett | SEA | Left O LB | 1 | 3 |
| Rodney McLeod | CAL | Left LB | 1 | 3 |
| Julian Okwara | NYG | O LB | 1 | 3 |
| Devin Bush | MIS | Left I LB | 1 | 2 |
| Kyzir White | PHI | Right LB | 1 | 2 |
| Marcus Maye | BAC | Free Safety | 1 | 2 |
| Alex Anzalone | DET | Middle LB | 1 | 2 |
| Jahlani Tavai | PHO | Right I LB | 1 | 1 |
| Logan Wilson | PHI | Left I LB | 1 | 1 |
| Jessie Bates | CLE | Free Safety | 1 | 1 |
| Arik Armstead | DAL | Right Tackle | 1 | 0 |
| Elandon Roberts | MIS | Left I LB | 1 | 0 |
| Christian Kirksey | OAK | Middle LB | 1 | 0 |
| Tyrel Dodson | CAL | LB | 1 | 0 |
| Derrick Brown | DAL | Left Tackle | 1 | 0 |
| Josey Jewell | SHR | Left I LB | 1 | 0 |
| Ernest Jones | GBP | Right I LB | 1 | 0 |
| Devin Lloyd | CHI | Left I LB | 1 | 0 |
| Zaire Franklin | BUF | Right LB | 1 | 0 |
| Montravius Adams | MIS | Nose Tackle | 1 | 0 |
| Sum | --- | --- | 537 | 3579 |
| Avg | --- | --- | 3 | 23 |