Player_Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Dennis Gardeck | HOU | Right O LB | 24 | 165 |
| Maxx Crosby | LAC | Left End | 18 | 137 |
| Ed Oliver | NOV | Left Tackle | 16 | 116 |
| T.J. Watt | ATL | Left O LB | 13 | 98 |
| Leonard Floyd | PHO | Left End | 13 | 97 |
| Christian Barmore | HOU | Left End | 12 | 95 |
| Chris Jones | SLC | Left Tackle | 12 | 87 |
| Quinnen Williams | OAK | Right Tackle | 11 | 70 |
| Jermaine Johnson | ATL | Right LB | 10 | 97 |
| Justin Madubuike | GRR | Right End | 10 | 92 |
| Jalen Carter | HOU | Def Tackle | 10 | 76 |
| Boye Mafe | NEP | Left O LB | 9 | 85 |
| Montez Sweat | NEP | Left End | 9 | 71 |
| Samson Ebukam | SEA | Right End | 9 | 63 |
| Jaelan Phillips | OAK | O LB | 9 | 61 |
| YaYa Diaby | TBB | Right O LB | 9 | 57 |
| Kwity Paye | MON | Left End | 9 | 55 |
| Carl Granderson | SHR | Right End | 8 | 64 |
| Bradley Chubb | LAR | Right O LB | 8 | 63 |
| Julian Blackmon | HOU | Left LB | 8 | 62 |
| Nick Bosa | NYJ | Left End | 8 | 61 |
| Jonathan Allen | LAC | Right Tackle | 8 | 49 |
| Kobie Turner | TBB | Def Tackle | 8 | 47 |
| Malcolm Koonce | HOU | Right End | 7 | 61 |
| Leonard Williams | HOO | Left End | 7 | 60 |
| Myles Garrett | STL | Right End | 7 | 43 |
| Vita Vea | TBB | Nose Tackle | 7 | 43 |
| Bryce Huff | ATL | Def End | 7 | 42 |
| Jarran Reed | NEP | Nose Tackle | 7 | 33 |
| DeForest Buckner | MON | Left Tackle | 7 | 33 |
| George Karlaftis | PHS | Left End | 6 | 53 |
| Sheldon Rankins | SLC | Left Tackle | 6 | 51 |
| Javon Hargrave | ATL | Right Tackle | 6 | 48 |
| Danielle Hunter | BUF | Left End | 6 | 43 |
| Karl Brooks | CAR | Def End | 6 | 37 |
| Jordan Whitehead | SHR | Free Safety | 6 | 34 |
| Mike Danna | LAR | Right End | 6 | 34 |
| Jordan Davis | SEA | Left Tackle | 6 | 30 |
| Maliek Collins | PHO | Right Tackle | 6 | 28 |
| Dexter Lawrence | GRR | Nose Tackle | 6 | 24 |
| Aaron Donald | SCS | Right End | 5 | 47 |
| Micah Parsons | SLC | Right End | 5 | 44 |
| Charles Omenihu | LAC | Def End | 5 | 36 |
| Michael Hoecht | OAK | Left O LB | 5 | 35 |
| Josh Allen | BAC | Right O LB | 5 | 34 |
| Greg Rousseau | SHR | Right End | 5 | 33 |
| Dayo Odeyingbo | CLE | Def End | 5 | 31 |
| Rashan Gary | PHS | Left O LB | 5 | 30 |
| Aidan Hutchinson | DET | Left End | 5 | 28 |
| Dalvin Tomlinson | BAC | Left Tackle | 5 | 25 |
| Elandon Roberts | NYJ | Left I LB | 5 | 12 |
| C.J. Mosley | OAK | Middle LB | 5 | 2 |
| David Onyemata | PHI | Nose Tackle | 4 | 41 |
| Za'Darius Smith | SEA | Left End | 4 | 40 |
| Clelin Ferrell | NOV | Right End | 4 | 39 |
| Christian Wilkins | CAR | Left End | 4 | 35 |
| Sione Takitaki | DET | Left LB | 4 | 34 |
| Devonte Wyatt | STL | Right End | 4 | 32 |
| John Franklin-Myers | TBB | Left End | 4 | 31 |
| Tuli Tuipulotu | LAC | Right O LB | 4 | 30 |
| Will Anderson Jr. | PHS | Left End | 4 | 30 |
| Jonathan Greenard | CLE | Right End | 4 | 30 |
| Casey Toohill | OAK | Right End | 4 | 28 |
| Jadeveon Clowney | NEP | Left End | 4 | 28 |
| Solomon Thomas | PHI | Right End | 4 | 27 |
| Mike Edwards | OAK | Safety | 4 | 27 |
| Kenny Clark | CLE | Left End | 4 | 26 |
| Dorance Armstrong | DAL | Def End | 4 | 25 |
| Jordyn Brooks | ATL | Left I LB | 4 | 18 |
| Calais Campbell | GRR | Right End | 4 | 17 |
| Zaire Franklin | LAC | Middle LB | 4 | 13 |
| Travon Walker | CLE | Left O LB | 3 | 29 |
| DeMarcus Walker | BAC | Right End | 3 | 28 |
| Derek Barnett | ATL | Def End | 3 | 28 |
| Calijah Kancey | NYG | Left End | 3 | 26 |
| Denico Autry | SCS | Right End | 3 | 25 |
| Zach Sieler | OKL | Right End | 3 | 25 |
| Keion White | HOU | Def End | 3 | 25 |
| Arik Armstead | NOV | Left Tackle | 3 | 25 |
| Alim McNeill | PHS | Right Tackle | 3 | 24 |
| Trey Hendrickson | BUF | Right End | 3 | 24 |
| A.J. Epenesa | NOV | Def End | 3 | 24 |
| Haason Reddick | HOO | Left LB | 3 | 20 |
| Grover Stewart | LAR | Right Tackle | 3 | 17 |
| DaQuan Jones | DAL | Right Tackle | 3 | 17 |
| Tashaun Gipson | LAC | Free Safety | 3 | 16 |
| Cody Barton | HOU | Middle LB | 3 | 15 |
| Zach Allen | NYG | Left End | 3 | 15 |
| Khalil Mack | HOO | Left O LB | 3 | 13 |
| Tremaine Edmunds | BUF | Middle LB | 3 | 12 |
| Michael Pierce | NOS | Nose Tackle | 3 | 9 |
| Osa Odighizuwa | DAL | Right Tackle | 3 | 8 |
| Mike Purcell | HAM | Nose Tackle | 3 | 8 |
| Christian Rozeboom | TBB | Right I LB | 2 | 19 |
| Chase Young | PHO | Def End | 2 | 18 |
| Quincy Williams | NEP | Left LB | 2 | 18 |
| Jonathan Ledbetter | OAK | Right End | 2 | 17 |
| Jevon Holland | SCS | Strong Safety | 2 | 17 |
| Brian Burns | CAR | Left O LB | 2 | 16 |
| Kyzir White | PHS | Left I LB | 2 | 16 |
| Bud Dupree | NEP | Left O LB | 2 | 16 |
| Jonathan Jones | SCS | Right CB | 2 | 16 |
| Derrick Brown | CAR | Left End | 2 | 16 |
| Bilal Nichols | LAR | Right Tackle | 2 | 13 |
| B.J. Hill | MON | Left Tackle | 2 | 13 |
| Roy Robertson-Harri | NOS | Right End | 2 | 13 |
| Oren Burks | SHR | Left LB | 2 | 12 |
| Sam Hubbard | TBB | Left End | 2 | 12 |
| Azeez Al-Shaair | MON | Left I LB | 2 | 12 |
| Brandon Graham | SLC | Def End | 2 | 11 |
| Darrell Taylor | DAL | O LB | 2 | 11 |
| Byron Young | PHO | Right O LB | 2 | 11 |
| Jonah Williams | SLC | Left End | 2 | 11 |
| Trent McDuffie | PHO | Right CB | 2 | 10 |
| Lavonte David | GRR | Right I LB | 2 | 10 |
| Raekwon Davis | SHR | Nose Tackle | 2 | 9 |
| Derrick Barnes | NYG | Left LB | 2 | 9 |
| Harrison Phillips | NYG | Nose Tackle | 2 | 8 |
| Ivan Pace Jr. | DAL | Right I LB | 2 | 7 |
| Amare Barno | HOU | O LB | 2 | 7 |
| Cameron Jordan | PHI | Left End | 2 | 6 |
| Daron Payne | DET | Left Tackle | 2 | 5 |
| Ernest Jones | PHO | Left I LB | 2 | 5 |
| Folorunso Fatukasi | ATL | Nose Tackle | 2 | 3 |
| Roquan Smith | CAR | Left I LB | 2 | 3 |
| Bobby Wagner | SEA | Right I LB | 2 | 0 |
| Davon Godchaux | HOO | Nose Tackle | 2 | 0 |
| Deonte Banks | PHS | Right CB | 1 | 14 |
| Josh Metellus | GRR | Left O LB | 1 | 12 |
| Harrison Smith | DAL | Strong Safety | 1 | 12 |
| Baron Browning | LAR | Right O LB | 1 | 11 |
| Rasul Douglas | NYJ | Right CB | 1 | 11 |
| Micah McFadden | DET | Left I LB | 1 | 11 |
| BJ Ojulari | STL | O LB | 1 | 11 |
| Nathan Shepherd | BUF | Left Tackle | 1 | 10 |
| David Long | LAR | Left I LB | 1 | 10 |
| Jalen Reeves-Maybin | NOV | I LB | 1 | 10 |
| Christian Benford | DET | Left CB | 1 | 10 |
| Jordan Battle | PHO | Strong Safety | 1 | 10 |
| Shelby Harris | MON | Def End | 1 | 10 |
| Jonathon Cooper | HAM | Left O LB | 1 | 10 |
| Xavien Howard | SHR | Left CB | 1 | 9 |
| Tyrel Dodson | NYJ | Right LB | 1 | 9 |
| Fred Warner | PHI | Middle LB | 1 | 9 |
| Julian Love | GRR | Strong Safety | 1 | 9 |
| Henry To'o To'o | DAL | LB | 1 | 8 |
| Andrew Van Ginkel | MON | Left O LB | 1 | 8 |
| Joey Bosa | LAR | Left End | 1 | 8 |
| Alex Singleton | NEP | Right I LB | 1 | 8 |
| Kevin Strong | NYJ | Def End | 1 | 8 |
| Joe Tryon-Shoyinka | LAC | O LB | 1 | 8 |
| Yetur Gross-Matos | OKL | Right O LB | 1 | 8 |
| Larry Ogunjobi | DAL | Left End | 1 | 8 |
| Justin Jones | PHO | Left Tackle | 1 | 8 |
| Anfernee Jennings | PHO | Right O LB | 1 | 8 |
| Ifeatu Melifonwu | BUF | Strong Safety | 1 | 7 |
| Kyle Dugger | LAR | Strong Safety | 1 | 7 |
| Marcus Epps | PHO | Free Safety | 1 | 7 |
| Harold Landry | DET | Left O LB | 1 | 7 |
| Nick Herbig | SLC | O LB | 1 | 7 |
| Preston Smith | NYJ | Right O LB | 1 | 7 |
| Ashtyn Davis | PHS | 1st Defensive Back | 1 | 7 |
| Dante Fowler | ATL | Def End | 1 | 7 |
| Zach Cunningham | MON | Right LB | 1 | 7 |
| Andrew Billings | BAC | Right Tackle | 1 | 7 |
| Jabrill Peppers | NEP | Free Safety | 1 | 7 |
| DeShon Elliott | STL | Free Safety | 1 | 6 |
| Kingsley Enagbare | GRR | O LB | 1 | 6 |
| Alex Highsmith | NYG | Right O LB | 1 | 6 |
| Lorenzo Carter | NOV | O LB | 1 | 6 |
| Jaylinn Hawkins | SHR | 1st Defensive Back | 1 | 5 |
| Foyesade Oluokun | NYG | Right I LB | 1 | 5 |
| A.J. Terrell | STL | Right CB | 1 | 5 |
| Kevin Byard III | MON | Strong Safety | 1 | 5 |
| Jalen Pitre | LAC | Free Safety | 1 | 4 |
| Jeffery Simmons | DET | Left End | 1 | 4 |
| Kaden Elliss | PHI | Right I LB | 1 | 4 |
| Jordan Fuller | ATL | Strong Safety | 1 | 3 |
| Asante Samuel Jr. | MON | Left CB | 1 | 3 |
| DeMarcus Lawrence | OKL | Left End | 1 | 3 |
| Demario Davis | HOO | Middle LB | 1 | 2 |
| Bobby Okereke | SCS | Right I LB | 1 | 2 |
| Mack Wilson | BAC | I LB | 1 | 2 |
| Leo Chenal | TBB | Left LB | 1 | 2 |
| Jaylen Watson | BUF | CB | 1 | 2 |
| Da'Shawn Hand | SCS | Def Tackle | 1 | 1 |
| Budda Baker | NEP | Free Safety | 1 | 0 |
| Malcolm Roach | STL | Def Tackle | 1 | 0 |
| Vonn Bell | HAM | Strong Safety | 1 | 0 |
| D.J. Reader | BUF | Right Tackle | 1 | 0 |
| Robert Spillane | NOS | Middle LB | 1 | 0 |
| Jonathan Harris | SCS | Def Tackle | 1 | 0 |
| Camryn Bynum | BUF | Free Safety | 1 | 0 |
| Quay Walker | GRR | Right I LB | 1 | 0 |
| Jordan Hicks | HAM | Left I LB | 1 | 0 |
| Kwon Alexander | SHR | I LB | 1 | 0 |
| Sum | --- | --- | 699 | 4697 |
| Avg | --- | --- | 4 | 24 |