| League Record Book | |||||
| Passing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Completions | Jared Goff - New Orleans-NOV | Cleveland | 11/28/2021 | Cleveland 35-18 | 38 |
| Most Passing Yards | Joe Burrow - New York | Dallas | 9/12/2021 | New York 31-28 | 460 |
| Best Avg Yards Per Pass | Jameis Winston - Phoenix | Oakland | 9/26/2021 | Phoenix 37-22 | 13.5 |
| Longest Completion | Russell Wilson - Seattle | Jacksonville | 9/19/2021 | Seattle 34-17 | 80 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Completions | New Orleans-NOV | Cleveland | 11/28/2021 | Cleveland 35-18 | 38 |
| Most Passing Yards | New York | Dallas | 9/12/2021 | New York 31-28 | 460 |
| Best Avg Yards Per Pass | Dallas | Los Angeles-LAC | 11/28/2021 | Dallas 38-23 | 13.1 |
| Longest Completion | Seattle | Jacksonville | 9/19/2021 | Seattle 34-17 | 80 |
| Rushing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Carries | Nick Chubb - Chicago | Seattle | 12/26/2021 | Chicago 29-24 | 29 |
| Most Rushing Yards | Elijah Mitchell - Los Angeles-LAM | Buffalo | 10/3/2021 | Los Angeles-LAM 25-0 | 212 |
| Best Rushing Avg | Rashaad Penny - Dallas | Los Angeles-LAD | 10/10/2021 | Dallas 38-17 | 13.2 |
| Longest Carry | Rashaad Penny - Dallas | New York | 9/12/2021 | New York 31-28 | 71 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Carries | Los Angeles-LAM | Buffalo | 10/3/2021 | Los Angeles-LAM 25-0 | 55 |
| Most Rushing Yards | Los Angeles-LAM | Buffalo | 10/3/2021 | Los Angeles-LAM 25-0 | 342 |
| Best Rushing Avg | San Francisco | Los Angeles-LAD | 10/24/2021 | San Francisco 41-36 | 10.4 |
| Longest Carry | Dallas | New York | 9/12/2021 | New York 31-28 | 71 |
| Receiving Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Receptions | DK Metcalf - Detroit | Los Angeles-LAC | 12/19/2021 | Detroit 31-21 | 15 |
| Most Receiving Yards | Ja'Marr Chase - Dallas | Los Angeles-LAC | 11/28/2021 | Dallas 38-23 | 271 |
| Best Reception Yardage Avg | Van Jefferson - Dallas | Shreveport | 10/3/2021 | Dallas 45-9 | 32.4 |
| Longest Reception | Amari Cooper - Seattle | Jacksonville | 9/19/2021 | Seattle 34-17 | 80 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Receptions | New Orleans-NOV | Cleveland | 11/28/2021 | Cleveland 35-18 | 38 |
| Most Receiving Yards | New York | Dallas | 9/12/2021 | New York 31-28 | 460 |
| Best Reception Yardage Avg | Los Angeles-LAM | Missouri | 11/28/2021 | Los Angeles-LAM 39-24 | 26.6 |
| Longest Reception | Seattle | Jacksonville | 9/19/2021 | Seattle 34-17 | 80 |
| Kickoff Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Diontae Spencer - Texas Tech | Shreveport | 10/10/2021 | Shreveport 26-16 | 5 |
| Best Return Yardage Avg | Braxton Berrios - Dallas | New York | 12/5/2021 | Dallas 28-21 | 98.0 |
| Longest Return | Braxton Berrios - Dallas | New York | 12/5/2021 | Dallas 28-21 | 98 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | Los Angeles-LAD | Dallas | 10/10/2021 | Dallas 38-17 | 7 |
| Best Return Yardage Avg | Dallas | New York | 12/5/2021 | Dallas 28-21 | 54.0 |
| Longest Return | Dallas | New York | 12/5/2021 | Dallas 28-21 | 98 |
| Punt Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Jaelon Darden - Los Angeles-LAC | Baltimore | 12/5/2021 | Los Angeles-LAC 19-16 | 5 |
| Best Return Yardage Avg | Gunner Olszewski - Shreveport | Texas Tech | 10/10/2021 | Shreveport 26-16 | 81.0 |
| Longest Return | Gunner Olszewski - Shreveport | Texas Tech | 10/10/2021 | Shreveport 26-16 | 81 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | Chicago | Detroit | 9/19/2021 | Detroit 17-10 | 5 |
| Best Return Yardage Avg | Shreveport | Texas Tech | 10/10/2021 | Shreveport 26-16 | 81.0 |
| Longest Return | Shreveport | Texas Tech | 10/10/2021 | Shreveport 26-16 | 81 |
| Defense Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Tackles | Kyzir White - California | Cleveland | 9/12/2021 | Cleveland 31-21 | 17 |
| Sacks | Rashan Gary - Los Angeles-LAM | Seattle | 9/26/2021 | Seattle 20-16 | 4 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Tackles | Philadelphia | San Francisco | 9/12/2021 | San Francisco 30-27 | 65 |
| Sacks | Los Angeles-LAM | Oakland | 11/14/2021 | Los Angeles-LAM 24-10 | 9 |
| Interception Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Interceptions | Sean Chandler - New Orleans-NOV | Buffalo | 12/12/2021 | New Orleans-NOV 37-14 | 3 |
| Best Interception Yardage Avg | Darrell Taylor - Baltimore | Green Bay | 10/24/2021 | Baltimore 28-0 | 89.0 |
| Longest Interception | Darrell Taylor - Baltimore | Green Bay | 10/24/2021 | Baltimore 28-0 | 89 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Interceptions | Southern California | Jacksonville | 10/31/2021 | Southern California 31-21 | 5 |
| Best Interception Yardage Avg | Baltimore | Green Bay | 10/24/2021 | Baltimore 28-0 | 89.0 |
| Longest Interception | Baltimore | Green Bay | 10/24/2021 | Baltimore 28-0 | 89 |