Player_Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Rashan Gary | LAM | Left O LB | 24 | 182 |
| Vonn Bell | LAM | Strong Safety | 15 | 112 |
| Matt Judon | NOS | Left O LB | 14 | 95 |
| Trey Hendrickson | OAK | Right End | 12 | 95 |
| Chris Jones | LAD | Right Tackle | 12 | 67 |
| Robert Quinn | OAK | Right O LB | 10 | 93 |
| Tyus Bowser | LAM | Left O LB | 10 | 49 |
| DeForest Buckner | LAM | Left Tackle | 9 | 59 |
| Aaron Donald | PHO | Right End | 8 | 69 |
| Chandler Jones | SHR | Right O LB | 8 | 64 |
| Myles Garrett | CLE | Right End | 8 | 61 |
| Azeez Ojulari | LAM | Left O LB | 8 | 61 |
| Sam Hubbard | MIS | Left End | 8 | 59 |
| Von Miller | LAD | Left O LB | 8 | 51 |
| Jonathan Allen | SF4 | Right Tackle | 8 | 49 |
| Arik Armstead | DAL | Left Tackle | 7 | 58 |
| Jonathan Greenard | SEA | Right End | 7 | 41 |
| Fletcher Cox | LAC | Right Tackle | 7 | 39 |
| Brian Burns | DAL | Left End | 6 | 55 |
| Haason Reddick | LAC | Left LB | 6 | 53 |
| Joey Bosa | PHI | Left O LB | 6 | 49 |
| Micah Parsons | OAK | Left LB | 6 | 48 |
| Nick Bosa | CLE | Left End | 6 | 47 |
| Greg Gaines | PHI | Nose Tackle | 6 | 42 |
| Marcus Davenport | CHI | Right End | 6 | 41 |
| Markus Golden | DAL | Left O LB | 6 | 38 |
| Yannick Ngakoue | DAL | Right End | 6 | 34 |
| Jaelan Phillips | CLE | Left O LB | 6 | 31 |
| Jadeveon Clowney | MIS | Left End | 5 | 38 |
| Montez Sweat | LAM | Right End | 5 | 36 |
| Denico Autry | NOS | Left End | 5 | 34 |
| Micah Hyde | SEA | Free Safety | 5 | 32 |
| Cameron Jordan | DET | Left End | 5 | 31 |
| Maliek Collins | PHO | Right Tackle | 5 | 27 |
| Harold Landry | DET | Left O LB | 5 | 23 |
| Leonard Floyd | PHO | Right O LB | 5 | 22 |
| Odafe Oweh | MIS | O LB | 4 | 36 |
| Alex Highsmith | DET | Right O LB | 4 | 34 |
| Darrell Taylor | BAC | Left End | 4 | 32 |
| T.J. Watt | PHO | Left O LB | 4 | 31 |
| Chris Wormley | PHO | Left End | 4 | 31 |
| Jeffery Simmons | DET | Right End | 4 | 27 |
| Kenny Clark | GBP | Nose Tackle | 4 | 23 |
| Larry Ogunjobi | CHI | Right Tackle | 4 | 20 |
| Devin Bush | MIS | Right I LB | 4 | 17 |
| Jarran Reed | CLE | Left Tackle | 4 | 14 |
| Al Woods | LAC | Left Tackle | 3 | 30 |
| J. Owusu-Koramoah | GBP | Right LB | 3 | 28 |
| Cameron Heyward | SCS | Right End | 3 | 27 |
| Harrison Phillips | DAL | Right Tackle | 3 | 27 |
| Anthony Walker | CHI | Middle LB | 3 | 26 |
| Trevis Gipson | NOV | Left O LB | 3 | 25 |
| Dalvin Tomlinson | SEA | Left Tackle | 3 | 24 |
| Armon Watts | MIS | Def Tackle | 3 | 23 |
| Anthony Barr | CLE | Left LB | 3 | 23 |
| Corey Peters | OAK | Nose Tackle | 3 | 22 |
| Bobby Wagner | SEA | Middle LB | 3 | 20 |
| Mario Addison | GBP | Def End | 3 | 20 |
| Jake Martin | CAL | Left End | 3 | 20 |
| Jerry Hughes | SHR | Right End | 3 | 19 |
| Emmanuel Ogbah | GBP | Def End | 3 | 18 |
| Quinnen Williams | SCS | Right Tackle | 3 | 16 |
| A.J. Klein | NOS | Left LB | 3 | 16 |
| Damien Wilson | SHR | Left I LB | 3 | 4 |
| Brandon Williams | SHR | Nose Tackle | 3 | 2 |
| Charles Harris | SF4 | Right O LB | 2 | 27 |
| Pernell McPhee | LAD | O LB | 2 | 22 |
| Raekwon Davis | MIS | Nose Tackle | 2 | 20 |
| Matt Milano | SF4 | Right LB | 2 | 20 |
| DeMarcus Lawrence | JAC | Left End | 2 | 20 |
| D.J. Jones | SEA | Right Tackle | 2 | 19 |
| Josh Allen | LAC | Left O LB | 2 | 19 |
| Lorenzo Carter | GBP | Right O LB | 2 | 19 |
| Dean Lowry | NYG | Left End | 2 | 18 |
| C.J. Mosley | DAL | Middle LB | 2 | 18 |
| Preston Smith | BAC | Right O LB | 2 | 17 |
| Zach Cunningham | LAM | Right I LB | 2 | 16 |
| William Jackson III | OAK | Left CB | 2 | 16 |
| Rock Ya-Sin | CLE | Left CB | 2 | 16 |
| Deatrich Wise Jr | PHI | Right End | 2 | 15 |
| Jimmie Ward | GBP | Free Safety | 2 | 15 |
| Mike Danna | LAC | Def End | 2 | 14 |
| Ed Oliver | NYG | Left Tackle | 2 | 14 |
| Shaquil Barrett | SEA | Left O LB | 2 | 14 |
| Shaq Thompson | OAK | Right LB | 2 | 13 |
| John Johnson III | NOS | Free Safety | 2 | 13 |
| Isaiah Simmons | OAK | Left I LB | 2 | 13 |
| Nick Williams | LAC | Left End | 2 | 13 |
| Minkah Fitzpatrick | MIS | Free Safety | 2 | 13 |
| DaQuan Jones | NOS | Right Tackle | 2 | 12 |
| Derek Barnett | SEA | Right End | 2 | 12 |
| Jerome Baker | BUF | Right I LB | 2 | 12 |
| Greg Rousseau | NOV | Left End | 2 | 9 |
| Akiem Hicks | BUF | Left End | 2 | 9 |
| Grover Stewart | LAD | Right Tackle | 2 | 8 |
| Budda Baker | LAC | Free Safety | 2 | 8 |
| Tae Crowder | MIS | Right I LB | 2 | 5 |
| Tyeler Davison | JAC | Nose Tackle | 2 | 2 |
| D.J. Reader | BAC | Left Tackle | 2 | 0 |
| Leonard Williams | CHI | Right End | 1 | 13 |
| Chidobe Awuzie | CLE | Right CB | 1 | 12 |
| Shelby Harris | CAL | Right End | 1 | 12 |
| Antoine Winfield Jr. | BAC | Free Safety | 1 | 12 |
| Arden Key | SF4 | Def End | 1 | 12 |
| Rasheem Green | LAC | Right End | 1 | 11 |
| William Gholston | BUF | Right End | 1 | 11 |
| Boogie Basham | BUF | Def End | 1 | 11 |
| Alex Singleton | NOS | Right LB | 1 | 10 |
| John Franklin-Myers | SCS | Left End | 1 | 10 |
| Grady Jarrett | NOV | Right End | 1 | 10 |
| Jayron Kearse | DET | Strong Safety | 1 | 10 |
| Roquan Smith | BUF | Left I LB | 1 | 10 |
| Jaquiski Tartt | MIS | Strong Safety | 1 | 10 |
| K'Lavon Chaisson | CHI | Right O LB | 1 | 10 |
| Malcolm Smith | MIS | Left LB | 1 | 10 |
| Pete Werner | DET | Left LB | 1 | 9 |
| Michael Pierce | CHI | Right Tackle | 1 | 9 |
| T.J. Edwards | NOS | Middle LB | 1 | 9 |
| Sheldon Richardson | NOV | Def Tackle | 1 | 8 |
| Tremaine Edmunds | CLE | Middle LB | 1 | 8 |
| Xavier Woods | SCS | Free Safety | 1 | 8 |
| Malik McDowell | BUF | Right Tackle | 1 | 8 |
| Jordan Hicks | PHI | Right I LB | 1 | 7 |
| Kendall Fuller | SCS | Right CB | 1 | 7 |
| Fred Warner | PHO | Middle LB | 1 | 7 |
| Logan Wilson | PHI | Right LB | 1 | 6 |
| Rashad Fenton | PHO | Right CB | 1 | 6 |
| Justin Houston | SHR | Right O LB | 1 | 6 |
| Pat Surtain II | DET | Left CB | 1 | 6 |
| Ja'Whaun Bentley | TTR | Left I LB | 1 | 6 |
| Adrian Phillips | PHO | Strong Safety | 1 | 5 |
| Malik Hooker | PHI | Strong Safety | 1 | 5 |
| Nick Bolton | NOV | Right LB | 1 | 5 |
| Eddie Jackson | SHR | Free Safety | 1 | 5 |
| James Bradberry | MIS | Left CB | 1 | 5 |
| Devin McCourty | DET | Free Safety | 1 | 4 |
| Donte Jackson | DAL | Right CB | 1 | 4 |
| Carlton Davis | DET | Left CB | 1 | 3 |
| De'Vondre Campbell | PHI | Left I LB | 1 | 3 |
| Maxx Crosby | TTR | Left End | 1 | 3 |
| Justin Simmons | CHI | Free Safety | 1 | 3 |
| Demario Davis | SF4 | Middle LB | 1 | 2 |
| Joe Schobert | NOV | Left I LB | 1 | 0 |
| Germaine Pratt | NYG | Middle LB | 1 | 0 |
| Alex Anzalone | DET | Left I LB | 1 | 0 |
| Rakeem Nunez-Roches | CAL | Def Tackle | 1 | 0 |
| Vita Vea | TTR | Nose Tackle | 1 | 0 |
| Malcom Brown | BUF | Nose Tackle | 1 | 0 |
| Mykal Walker | TTR | I LB | 1 | 0 |
| Derrek Tuszka | DAL | O LB | 1 | 0 |
| Ernest Jones | GBP | Left I LB | 1 | 0 |
| Sum | --- | --- | 500 | 3452 |
| Avg | --- | --- | 3 | 23 |