| League Record Book | |||||
| Passing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Completions | Andy Dalton - Phoenix | New York | 11/13/2022 | Phoenix 20-17 | 39 |
| Most Passing Yards | Geno Smith - Seattle | Atlanta | 10/16/2022 | Seattle 30-21 | 418 |
| Best Avg Yards Per Pass | Kyler Murray - Hawaii | Southern California | 12/11/2022 | Hawaii 44-30 | 11.7 |
| Longest Completion | Derek Carr - Atlanta | Los Angeles-LAR | 10/30/2022 | Los Angeles-LAR 17-13 | 81 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Completions | Phoenix | New York | 11/13/2022 | Phoenix 20-17 | 39 |
| Most Passing Yards | Seattle | Atlanta | 10/16/2022 | Seattle 30-21 | 418 |
| Best Avg Yards Per Pass | Hawaii | Southern California | 12/11/2022 | Hawaii 44-30 | 11.7 |
| Longest Completion | Atlanta | Los Angeles-LAR | 10/30/2022 | Los Angeles-LAR 17-13 | 81 |
| Rushing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Carries | Nick Chubb - Portland | Atlanta | 12/4/2022 | Portland 27-9 | 35 |
| Most Rushing Yards | Nick Chubb - Portland | Atlanta | 12/4/2022 | Portland 27-9 | 307 |
| Best Rushing Avg | Justin Fields - New Orleans | Kentucky | 10/2/2022 | Kentucky 34-30 | 16.5 |
| Longest Carry | Austin Ekeler - New England | Buffalo | 10/30/2022 | Buffalo 30-27 | 72 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Carries | Los Angeles-LAR | Minnesota | 12/25/2022 | Los Angeles-LAR 35-17 | 47 |
| Most Rushing Yards | Portland | Atlanta | 12/4/2022 | Portland 27-9 | 354 |
| Best Rushing Avg | New Orleans | Kentucky | 10/2/2022 | Kentucky 34-30 | 12.3 |
| Longest Carry | New England | Buffalo | 10/30/2022 | Buffalo 30-27 | 72 |
| Receiving Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Receptions | Kyle Pitts - Los Angeles-LAC | Indianapolis | 12/11/2022 | Los Angeles-LAC 34-27 | 16 |
| Most Receiving Yards | Justin Watson - Hawaii | Southern California | 12/11/2022 | Hawaii 44-30 | 212 |
| Best Reception Yardage Avg | Justin Watson - Hawaii | Southern California | 12/11/2022 | Hawaii 44-30 | 42.4 |
| Longest Reception | DJ Chark - Atlanta | Los Angeles-LAR | 10/30/2022 | Los Angeles-LAR 17-13 | 81 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Receptions | Phoenix | New York | 11/13/2022 | Phoenix 20-17 | 39 |
| Most Receiving Yards | Seattle | Atlanta | 10/16/2022 | Seattle 30-21 | 418 |
| Best Reception Yardage Avg | San Francisco | Phoenix | 11/20/2022 | San Francisco 20-6 | 20.5 |
| Longest Reception | Atlanta | Los Angeles-LAR | 10/30/2022 | Los Angeles-LAR 17-13 | 81 |
| Kickoff Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Gary Brightwell - Oklahoma | Philadelphia | 12/11/2022 | Philadelphia 44-20 | 6 |
| Best Return Yardage Avg | Devin Duvernay - Texas Tech | Cincinnati | 12/4/2022 | Texas Tech 42-38 | 91.0 |
| Longest Return | Nyheim Hines - Atlanta | New England | 12/18/2022 | Atlanta 37-20 | 108 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | San Antonio | Southern California | 11/6/2022 | Southern California 19-16 | 6 |
| Best Return Yardage Avg | Texas Tech | Cincinnati | 12/4/2022 | Texas Tech 42-38 | 91.0 |
| Longest Return | Atlanta | New England | 12/18/2022 | Atlanta 37-20 | 108 |
| Punt Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Marcus Jones - New England | New York | 10/2/2022 | New York 13-13 | 5 |
| Best Return Yardage Avg | Devin Duvernay - Texas Tech | Pittsburgh | 11/20/2022 | Texas Tech 33-3 | 46.0 |
| Longest Return | D. Peoples-Jones - Texas Tech | Pittsburgh | 11/20/2022 | Texas Tech 33-3 | 58 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | New England | New York | 10/2/2022 | New York 13-13 | 5 |
| Best Return Yardage Avg | Texas Tech | Pittsburgh | 11/20/2022 | Texas Tech 33-3 | 37.3 |
| Longest Return | Texas Tech | Pittsburgh | 11/20/2022 | Texas Tech 33-3 | 58 |
| Defense Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Tackles | Devin White - New England | New York | 10/2/2022 | New York 13-13 | 18 |
| Sacks | Harrison Phillips - Phoenix | Texas Tech | 10/30/2022 | Phoenix 38-21 | 5 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Tackles | New England | New York | 10/2/2022 | New York 13-13 | 63 |
| Sacks | Oklahoma | Houston | 11/20/2022 | Oklahoma 25-16 | 11 |
| Interception Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Interceptions | Donovan Wilson - Texas Tech | New Orleans | 9/18/2022 | Texas Tech 37-21 | 3 |
| Best Interception Yardage Avg | Malcolm Rodriguez - San Francisco | Buffalo | 10/2/2022 | San Francisco 30-14 | 88.0 |
| Longest Interception | Darnell Savage - Pittsburgh | Los Angeles-LAR | 9/18/2022 | Pittsburgh 17-9 | 100 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Interceptions | New Orleans | Atlanta | 11/20/2022 | Atlanta 21-17 | 5 |
| Best Interception Yardage Avg | San Antonio | New York | 12/4/2022 | San Antonio 28-24 | 71.0 |
| Longest Interception | Pittsburgh | Los Angeles-LAR | 9/18/2022 | Pittsburgh 17-9 | 100 |