Player_Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Micah Parsons | NEP | Right LB | 19 | 146 |
| Chris Jones | HOU | Left Tackle | 18 | 101 |
| J.J. Watt | POR | Left End | 15 | 118 |
| Josh Sweat | IND | Right End | 15 | 100 |
| Matt Judon | POR | Right O LB | 14 | 99 |
| Nick Bosa | HRW | Left End | 13 | 94 |
| Uchenna Nwosu | SEA | Left O LB | 13 | 86 |
| Greg Gaines | PHI | Nose Tackle | 12 | 90 |
| Cameron Heyward | SF4 | Right End | 12 | 84 |
| Myles Garrett | DET | Right End | 12 | 79 |
| Haason Reddick | PIT | Left LB | 11 | 81 |
| Quinnen Williams | LAC | Right Tackle | 11 | 67 |
| Danielle Hunter | SEA | Left O LB | 10 | 93 |
| DeMarcus Lawrence | HOU | Left End | 10 | 79 |
| Dexter Lawrence | TTR | Nose Tackle | 10 | 49 |
| Brian Burns | LAC | Right End | 9 | 75 |
| Bradley Chubb | NEP | Right O LB | 9 | 59 |
| Javon Hargrave | LAR | Right Tackle | 9 | 55 |
| Bruce Irvin | LAR | Right O LB | 8 | 59 |
| Jeffery Simmons | POR | Left End | 8 | 48 |
| Cameron Jordan | SCS | Left End | 8 | 46 |
| Carl Granderson | SAG | Def End | 7 | 60 |
| Leonard Floyd | OKL | Left O LB | 7 | 50 |
| Daron Payne | OKL | Left Tackle | 7 | 50 |
| Aidan Hutchinson | BUF | Left End | 7 | 46 |
| James Houston IV | POR | O LB | 7 | 43 |
| Harrison Phillips | PHO | Nose Tackle | 7 | 35 |
| Jonathan Allen | OKL | Right Tackle | 6 | 53 |
| Chuck Clark | SCS | Strong Safety | 6 | 52 |
| DeForest Buckner | PIT | Left Tackle | 6 | 41 |
| Deatrich Wise Jr. | NYG | Right End | 6 | 37 |
| Fletcher Cox | PHO | Left End | 6 | 36 |
| Michael Hoecht | LAR | Right O LB | 6 | 36 |
| Montez Sweat | OKL | Right End | 6 | 35 |
| Carlos Dunlap | LAR | Def End | 5 | 52 |
| Kenny Clark | SEA | Nose Tackle | 5 | 45 |
| Al Woods | MIN | Nose Tackle | 5 | 43 |
| Sam Hubbard | NEP | Left O LB | 5 | 42 |
| Preston Smith | PHI | Right O LB | 5 | 42 |
| Kyle Van Noy | PIT | Left O LB | 5 | 41 |
| T.J. Watt | SEA | Left O LB | 5 | 34 |
| Khalil Mack | SCS | Right O LB | 5 | 34 |
| Trey Hendrickson | OKL | Right O LB | 5 | 33 |
| Jaelan Phillips | OKL | Left O LB | 5 | 32 |
| Frank Clark | LAR | Right End | 5 | 32 |
| Grover Stewart | CIN | Right Tackle | 5 | 29 |
| DaVon Hamilton | HRW | Nose Tackle | 5 | 18 |
| Chandler Jones | NYG | Right End | 4 | 37 |
| Jason Pierre-Paul | SF4 | Right O LB | 4 | 36 |
| Minkah Fitzpatrick | ATL | Free Safety | 4 | 35 |
| Sheldon Rankins | SAG | Left Tackle | 4 | 32 |
| Shy Tuttle | LAC | Left Tackle | 4 | 32 |
| Joey Bosa | TTR | Left End | 4 | 29 |
| Alex Highsmith | DET | Right O LB | 4 | 29 |
| Vita Vea | ATL | Nose Tackle | 4 | 28 |
| Jerry Hughes | SCS | Left End | 4 | 28 |
| Von Miller | SAG | Left LB | 4 | 26 |
| Yannick Ngakoue | SEA | Right End | 4 | 26 |
| Maxx Crosby | NEP | Left End | 4 | 26 |
| Julian Okwara | LAC | O LB | 4 | 24 |
| Denzel Perryman | HOU | Middle LB | 4 | 17 |
| Damone Clark | SCS | LB | 4 | 17 |
| Fred Warner | ATL | Middle LB | 4 | 8 |
| Leki Fotu | IND | Nose Tackle | 4 | 5 |
| Ryan Neal | HOU | Strong Safety | 3 | 32 |
| Ogbonnia Okoronkwo | MIN | Right End | 3 | 29 |
| Roy Lopez | BUF | Left Tackle | 3 | 29 |
| Darnell Savage | PIT | Free Safety | 3 | 26 |
| Aaron Donald | BUF | Right End | 3 | 25 |
| Odafe Oweh | LAC | Left O LB | 3 | 25 |
| Justin Madubuike | NOV | Right End | 3 | 22 |
| Brandon Graham | PHO | Def End | 3 | 21 |
| Kaden Elliss | CIN | Left LB | 3 | 20 |
| Marquise Copeland | POR | Def Tackle | 3 | 20 |
| Calais Campbell | ATL | Left End | 3 | 18 |
| Grady Jarrett | SF4 | Right End | 3 | 17 |
| Drue Tranquill | IND | Left I LB | 3 | 17 |
| Jamin Davis | IND | Left LB | 3 | 16 |
| Christian Kirksey | LAR | Middle LB | 3 | 16 |
| De'Vondre Campbell | PHO | Left I LB | 3 | 15 |
| Alex Anzalone | SEA | Middle LB | 3 | 15 |
| Quinton Bohanna | SF4 | Right Tackle | 3 | 9 |
| Foyesade Oluokun | PIT | Right I LB | 3 | 8 |
| Alex Singleton | SF4 | Right I LB | 3 | 7 |
| Montravius Adams | KEN | Nose Tackle | 3 | 0 |
| Logan Wilson | KEN | Left I LB | 3 | 0 |
| Jerome Baker | CIN | Right I LB | 3 | 0 |
| Patrick Queen | HRW | Left I LB | 2 | 26 |
| Rasheem Green | NOV | Def End | 2 | 21 |
| Melvin Ingram III | ATL | O LB | 2 | 19 |
| Vonn Bell | LAC | Strong Safety | 2 | 18 |
| Folorunso Fatukasi | KEN | Left End | 2 | 17 |
| Kwity Paye | DET | Left End | 2 | 17 |
| Efe Obada | ATL | Def End | 2 | 15 |
| Devin White | NEP | Left I LB | 2 | 14 |
| Marcus Davenport | PIT | Right End | 2 | 13 |
| Kevin Givens | SAG | Def Tackle | 2 | 13 |
| Duke Riley | IND | I LB | 2 | 11 |
| D.J. Reader | NOV | Nose Tackle | 2 | 10 |
| Bobby Wagner | NYG | Left I LB | 2 | 10 |
| Matt Milano | PHO | Right LB | 2 | 9 |
| Rashad Weaver | MIN | O LB | 2 | 9 |
| Devin Lloyd | LAC | Left I LB | 2 | 7 |
| Leo Chenal | NOV | Left LB | 2 | 6 |
| Demario Davis | PHI | Middle LB | 2 | 6 |
| Andrew Billings | NYG | Left Tackle | 2 | 5 |
| Mykal Walker | TTR | Right I LB | 2 | 4 |
| Shaq Thompson | ATL | Middle LB | 2 | 2 |
| Linval Joseph | POR | Left Tackle | 2 | 1 |
| C.J. Mosley | MIN | Middle LB | 2 | 1 |
| Arik Armstead | SF4 | Right Tackle | 2 | 0 |
| T.J. Edwards | HRW | Middle LB | 2 | 0 |
| Akiem Hicks | PHI | Left End | 1 | 13 |
| Micheal Clemons | LAC | Def End | 1 | 13 |
| Darrell Taylor | NYG | O LB | 1 | 12 |
| Marcus Maye | SEA | Free Safety | 1 | 12 |
| Joshua Kalu | LAR | Safety | 1 | 11 |
| Andrew Van Ginkel | ATL | O LB | 1 | 11 |
| Stephon Gilmore | OKL | Right CB | 1 | 9 |
| Juan Thornhill | PHO | Free Safety | 1 | 9 |
| Tremaine Edmunds | OKL | Middle LB | 1 | 9 |
| Troy Hill | MIN | Left CB | 1 | 9 |
| Dre Greenlaw | SCS | Right LB | 1 | 9 |
| Denico Autry | IND | Right End | 1 | 9 |
| Greg Rousseau | CIN | Left End | 1 | 9 |
| Josh Uche | NOV | O LB | 1 | 9 |
| Nicholas Morrow | PHI | Left LB | 1 | 8 |
| Sebastian Joseph-Day | NEP | Nose Tackle | 1 | 8 |
| John Franklin-Myers | KEN | Left End | 1 | 8 |
| Devin McCourty | PHI | Free Safety | 1 | 8 |
| Rashan Gary | SAG | Left O LB | 1 | 8 |
| Taylor Rapp | LAC | Strong Safety | 1 | 8 |
| Quincy Williams | BUF | Left LB | 1 | 8 |
| Zach Sieler | SAG | Right End | 1 | 7 |
| Shaquil Barrett | MIN | Left O LB | 1 | 7 |
| Zaire Franklin | HOU | Right LB | 1 | 7 |
| Geno Stone | SCS | Safety | 1 | 7 |
| Jevon Holland | NEP | Free Safety | 1 | 7 |
| Eli Apple | PIT | Right CB | 1 | 6 |
| Kamren Curl | SF4 | Right LB | 1 | 6 |
| Josh Allen | HRW | Right O LB | 1 | 5 |
| James Smith-Williams | MIN | Left End | 1 | 4 |
| David Long | SAG | Left I LB | 1 | 4 |
| Carl Lawson | CIN | Right End | 1 | 4 |
| DeShawn Williams | HRW | Right End | 1 | 3 |
| Chauncey Gardner-Johnson | HRW | Strong Safety | 1 | 3 |
| Christian Wilkins | PHI | Left End | 1 | 3 |
| Leighton Vander Esch | BUF | Middle LB | 1 | 2 |
| Deion Jones | DET | Middle LB | 1 | 2 |
| Cameron Dantzler | SEA | Right CB | 1 | 2 |
| Ed Oliver | CIN | Right Tackle | 1 | 1 |
| Jaylon Smith | PHO | Right I LB | 1 | 0 |
| Teair Tart | DET | Nose Tackle | 1 | 0 |
| Zachary Carter | SCS | Right End | 1 | 0 |
| Derrick Nnadi | BUF | Right Tackle | 1 | 0 |
| Dylan Cole | LAR | Right I LB | 1 | 0 |
| Nick Bolton | KEN | Middle LB | 1 | 0 |
| Sum | --- | --- | 627 | 4115 |
| Avg | --- | --- | 4 | 26 |