| League Record Book | |||||
| Passing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Completions | Tom Brady - Hamilton | Seattle | 12/25/2022 | Hamilton 33-32 | 40 |
| Most Passing Yards | Tua Tagovailoa - New Orleans-NOV | Toronto | 12/18/2022 | New Orleans-NOV 49-30 | 422 |
| Best Avg Yards Per Pass | Tua Tagovailoa - New Orleans-NOV | Atlanta | 12/11/2022 | New Orleans-NOV 38-24 | 15.9 |
| Longest Completion | Matt Ryan - New Orleans-NOS | Shreveport | 10/23/2022 | Shreveport 29-27 | 85 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Completions | Hamilton | Seattle | 12/25/2022 | Hamilton 33-32 | 40 |
| Most Passing Yards | New Orleans-NOV | Toronto | 12/18/2022 | New Orleans-NOV 49-30 | 422 |
| Best Avg Yards Per Pass | New Orleans-NOV | Atlanta | 12/11/2022 | New Orleans-NOV 38-24 | 15.9 |
| Longest Completion | New Orleans-NOS | Shreveport | 10/23/2022 | Shreveport 29-27 | 85 |
| Rushing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Carries | Josh Jacobs - Oklahoma | Hamilton | 10/16/2022 | Oklahoma 33-13 | 31 |
| Most Rushing Yards | Najee Harris - Atlanta | Detroit | 10/16/2022 | Atlanta 33-30 | 215 |
| Best Rushing Avg | Justin Fields - New York-NYG | Cleveland | 11/27/2022 | New York-NYG 23-17 | 12.1 |
| Longest Carry | Lamar Jackson - Oklahoma | St. Louis-SLC | 9/18/2022 | Oklahoma 20-7 | 79 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Carries | Carolina | Hamilton | 9/11/2022 | Carolina 16-3 | 47 |
| Most Rushing Yards | Atlanta | Detroit | 10/16/2022 | Atlanta 33-30 | 321 |
| Best Rushing Avg | Oklahoma | Shreveport | 10/9/2022 | Shreveport 42-18 | 16.6 |
| Longest Carry | Oklahoma | St. Louis-SLC | 9/18/2022 | Oklahoma 20-7 | 79 |
| Receiving Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Receptions | Austin Ekeler - Hamilton | Seattle | 12/25/2022 | Hamilton 33-32 | 15 |
| Most Receiving Yards | Allen Lazard - New Orleans-NOV | Toronto | 12/18/2022 | New Orleans-NOV 49-30 | 223 |
| Best Reception Yardage Avg | Jalen Nailor - Houston-HOU | New York-NYJ | 10/9/2022 | New York-NYJ 40-39 | 35.7 |
| Longest Reception | Greg Dulcich - New Orleans-NOS | Shreveport | 10/23/2022 | Shreveport 29-27 | 85 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Receptions | Hamilton | Seattle | 12/25/2022 | Hamilton 33-32 | 40 |
| Most Receiving Yards | New Orleans-NOV | Toronto | 12/18/2022 | New Orleans-NOV 49-30 | 422 |
| Best Reception Yardage Avg | Tampa Bay | Los Angeles-LAM | 10/23/2022 | Los Angeles-LAM 26-16 | 26.8 |
| Longest Reception | New Orleans-NOS | Shreveport | 10/23/2022 | Shreveport 29-27 | 85 |
| Kickoff Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Ray-Ray McCloud - New Orleans-NOS | Cleveland | 9/11/2022 | Cleveland 34-24 | 5 |
| Best Return Yardage Avg | Britain Covey - St. Louis-STL | Houston-HOU | 11/27/2022 | Houston-HOU 45-28 | 101.0 |
| Longest Return | Britain Covey - St. Louis-STL | Houston-HOU | 11/27/2022 | Houston-HOU 45-28 | 101 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | Baltimore | Atlanta | 10/9/2022 | Atlanta 42-9 | 7 |
| Best Return Yardage Avg | New Orleans-NOV | Phoenix | 10/9/2022 | New Orleans-NOV 27-13 | 91.0 |
| Longest Return | St. Louis-STL | Houston-HOU | 11/27/2022 | Houston-HOU 45-28 | 101 |
| Punt Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Avery Williams - New York-NYG | Oakland | 11/20/2022 | New York-NYG 24-17 | 5 |
| Best Return Yardage Avg | Marcus Jones - New England | St. Louis-SLC | 11/27/2022 | New England 36-21 | 69.0 |
| Longest Return | Marcus Jones - New England | Tampa Bay | 11/20/2022 | New England 20-14 | 98 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | Shreveport | Philadelphia-PHS | 10/2/2022 | Shreveport 27-3 | 5 |
| Best Return Yardage Avg | New England | St. Louis-SLC | 11/27/2022 | New England 36-21 | 69.0 |
| Longest Return | New England | Tampa Bay | 11/20/2022 | New England 20-14 | 98 |
| Defense Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Tackles | Ja'Whaun Bentley - Hamilton | Carolina | 9/11/2022 | Carolina 16-3 | 18 |
| Sacks | Haason Reddick - Houston-HOO | New Orleans-NOV | 9/11/2022 | Houston-HOO 38-20 | 4 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Tackles | Detroit | Atlanta | 10/16/2022 | Atlanta 33-30 | 68 |
| Sacks | Houston-HOU | New Orleans-NOV | 11/20/2022 | Houston-HOU 32-21 | 10 |
| Interception Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Interceptions | Kevin Byard - Montreal | St. Louis-STL | 10/9/2022 | Montreal 35-15 | 3 |
| Best Interception Yardage Avg | Taron Johnson - New York-NYJ | Toronto | 10/23/2022 | New York-NYJ 28-12 | 82.0 |
| Longest Interception | Taron Johnson - New York-NYJ | Toronto | 10/23/2022 | New York-NYJ 28-12 | 82 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Interceptions | Atlanta | Los Angeles-LAC | 9/11/2022 | Atlanta 27-13 | 4 |
| Best Interception Yardage Avg | New York-NYJ | Toronto | 10/23/2022 | New York-NYJ 28-12 | 82.0 |
| Longest Interception | New York-NYJ | Toronto | 10/23/2022 | New York-NYJ 28-12 | 82 |