Player_Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Nick Bosa | NYJ | Left End | 17 | 120 |
| Quinnen Williams | OAK | Right Tackle | 17 | 112 |
| Daron Payne | DET | Left Tackle | 17 | 101 |
| James Houston IV | HOU | O LB | 15 | 111 |
| Julian Blackmon | HOU | Free Safety | 15 | 84 |
| Myles Garrett | STL | Right End | 14 | 121 |
| Khalil Mack | HOO | Right O LB | 14 | 85 |
| Chris Jones | SLC | Left Tackle | 13 | 96 |
| Vita Vea | TBB | Nose Tackle | 13 | 66 |
| Maxx Crosby | LAC | Left End | 12 | 89 |
| Darrell Taylor | DAL | O LB | 12 | 85 |
| Dexter Lawrence | GRR | Nose Tackle | 12 | 61 |
| Haason Reddick | HOO | Left LB | 11 | 60 |
| Aaron Donald | SCS | Right End | 10 | 86 |
| Brian Burns | CAR | Right End | 10 | 78 |
| Blake Cashman | HOU | O LB | 10 | 78 |
| Drake Jackson | STL | Def End | 9 | 73 |
| Micheal Clemons | HOU | Def End | 9 | 72 |
| Sam Hubbard | TBB | Left O LB | 9 | 71 |
| T.J. Watt | ATL | Left O LB | 9 | 69 |
| J.J. Watt | TOR | Left End | 9 | 65 |
| Teair Tart | SEA | Nose Tackle | 9 | 54 |
| Brandon Graham | SLC | Def End | 9 | 48 |
| Josh Uche | GRR | O LB | 9 | 47 |
| Cameron Heyward | HOO | Right End | 8 | 67 |
| Jerry Hughes | ATL | Left End | 8 | 63 |
| Carl Granderson | SHR | Def End | 8 | 57 |
| Payton Turner | HAM | Def End | 8 | 57 |
| Micah Parsons | SLC | Right LB | 8 | 53 |
| Joshua Kalu | ATL | Safety | 8 | 50 |
| Patrick Jones II | SEA | O LB | 8 | 45 |
| Matt Judon | MON | Right O LB | 7 | 55 |
| Rasheem Green | OAK | Def End | 7 | 50 |
| Leonard Floyd | PHO | Left O LB | 7 | 49 |
| Rashad Weaver | SEA | O LB | 7 | 48 |
| Jaelan Phillips | OAK | Left O LB | 7 | 47 |
| Drue Tranquill | NYJ | Left I LB | 7 | 32 |
| Fletcher Cox | LAC | Left End | 6 | 49 |
| Zach Allen | NYG | Right End | 6 | 46 |
| Amare Barno | HOU | Def End | 6 | 45 |
| Calais Campbell | GRR | Left End | 6 | 44 |
| Sheldon Rankins | SLC | Left Tackle | 6 | 43 |
| Alex Highsmith | NYG | Right O LB | 6 | 40 |
| Cameron Jordan | PHI | Left End | 6 | 39 |
| Efe Obada | SEA | Def End | 6 | 35 |
| Christian Barmore | HOU | Def End | 6 | 33 |
| Roy Lopez | NYJ | Left Tackle | 6 | 21 |
| Patrick Queen | SLC | Left I LB | 5 | 39 |
| DeMarcus Lawrence | DAL | Left End | 5 | 39 |
| Kwity Paye | MON | Left End | 5 | 34 |
| DeForest Buckner | MON | Left Tackle | 5 | 34 |
| Ed Oliver | NOV | Right Tackle | 5 | 30 |
| Davon Godchaux | HOO | Nose Tackle | 5 | 30 |
| Tony Jefferson | SHR | Safety | 5 | 29 |
| Jonathan Allen | LAC | Right Tackle | 5 | 28 |
| Andre Cisco | SEA | Free Safety | 5 | 26 |
| Za'Darius Smith | NOV | Right O LB | 5 | 19 |
| Zaire Franklin | LAC | Right LB | 4 | 37 |
| Jeffery Simmons | DET | Left End | 4 | 35 |
| Aidan Hutchinson | DET | Left End | 4 | 34 |
| Samson Ebukam | SEA | Right End | 4 | 34 |
| Trey Hendrickson | TOR | Right O LB | 4 | 31 |
| Deatrich Wise Jr. | NYJ | Right End | 4 | 30 |
| Chandler Jones | TOR | Right End | 4 | 30 |
| Frank Clark | OKL | Right End | 4 | 28 |
| Khalen Saunders | PHS | Def Tackle | 4 | 24 |
| Roquan Smith | CAR | Right I LB | 4 | 24 |
| Kenny Clark | CLE | Nose Tackle | 4 | 23 |
| Al Woods | SHR | Nose Tackle | 4 | 19 |
| Javon Hargrave | ATL | Right Tackle | 4 | 16 |
| Grover Stewart | LAM | Right Tackle | 4 | 13 |
| Alim McNeill | PHS | Left Tackle | 4 | 8 |
| Kayvon Thibodeaux | BAC | Right O LB | 3 | 35 |
| Bobby McCain | DET | Strong Safety | 3 | 34 |
| Osa Odighizuwa | DAL | Left Tackle | 3 | 29 |
| Darius Harris | DET | LB | 3 | 29 |
| Montez Sweat | NEP | Right End | 3 | 27 |
| Christian Wilkins | CAR | Left End | 3 | 26 |
| Greg Rousseau | SHR | Left End | 3 | 25 |
| Roy Robertson-Harri | NOS | Right End | 3 | 24 |
| Jeff Okudah | CAR | Right CB | 3 | 24 |
| Andrew Billings | BAC | Left Tackle | 3 | 23 |
| Denico Autry | SCS | Right End | 3 | 22 |
| A.J. Epenesa | NOV | Def End | 3 | 22 |
| Jevon Holland | SCS | Free Safety | 3 | 21 |
| Kurt Hinish | STL | Def Tackle | 3 | 20 |
| Josh Allen | BAC | Right O LB | 3 | 20 |
| Uchenna Nwosu | NYJ | Left O LB | 3 | 20 |
| Derrick Brown | CAR | Left Tackle | 3 | 19 |
| Sebastian Joseph-Day | OKL | Nose Tackle | 3 | 18 |
| Sione Takitaki | DET | Right LB | 3 | 17 |
| Jordyn Brooks | ATL | Left I LB | 3 | 14 |
| Isaiah Buggs | NOS | Right Tackle | 3 | 12 |
| Dorance Armstrong | DAL | Right End | 3 | 12 |
| Fred Warner | PHI | Middle LB | 3 | 12 |
| Carlos Davis | HAM | Def Tackle | 3 | 12 |
| Deion Jones | NEP | Middle LB | 3 | 10 |
| C.J. Mosley | OAK | Middle LB | 3 | 10 |
| Deadrin Senat | SCS | Def Tackle | 3 | 8 |
| Logan Wilson | NOS | Left I LB | 3 | 5 |
| DeShawn Williams | SLC | Right End | 2 | 21 |
| Arnold Ebiketie | PHS | Def End | 2 | 20 |
| Kyle Van Noy | NOS | Left O LB | 2 | 19 |
| Jeremiah Owusu-Koramoah | CAR | Left LB | 2 | 19 |
| Kamren Curl | NYJ | Right LB | 2 | 19 |
| Von Miller | SLC | Left LB | 2 | 19 |
| Rashan Gary | PHS | Left O LB | 2 | 18 |
| Joey Bosa | LAM | Left End | 2 | 16 |
| Jadeveon Clowney | CLE | Left End | 2 | 16 |
| Melvin Ingram III | HAM | O LB | 2 | 15 |
| Josh Sweat | NOS | Right End | 2 | 15 |
| Jessie Bates | GRR | Free Safety | 2 | 14 |
| Michael Hoecht | OAK | Right O LB | 2 | 14 |
| Ogbonnia Okoronkwo | NEP | Right End | 2 | 14 |
| Shelby Harris | MON | Right End | 2 | 14 |
| Maliek Collins | PHO | Right Tackle | 2 | 13 |
| Dre'Mont Jones | GRR | Left End | 2 | 12 |
| Cory Littleton | GRR | Right LB | 2 | 12 |
| Rudy Ford | DAL | Safety | 2 | 11 |
| Carlos Dunlap | PHI | Def End | 2 | 11 |
| Odafe Oweh | CAR | Left O LB | 2 | 10 |
| Derrick Nnadi | ATL | Right Tackle | 2 | 10 |
| Denzel Perryman | SHR | Middle LB | 2 | 10 |
| Ja'Whaun Bentley | HAM | Left I LB | 2 | 9 |
| Demario Davis | DAL | Middle LB | 2 | 7 |
| Linval Joseph | PHO | Left Tackle | 2 | 7 |
| Danielle Hunter | TOR | Left O LB | 2 | 7 |
| Harrison Phillips | NYG | Nose Tackle | 2 | 6 |
| Azeez Ojulari | DET | O LB | 2 | 6 |
| Zaven Collins | STL | Left I LB | 2 | 5 |
| DaQuan Jones | PHI | Left Tackle | 2 | 3 |
| Greg Gaines | NEP | Nose Tackle | 2 | 0 |
| Taven Bryan | PHI | Left Tackle | 2 | 0 |
| Tershawn Wharton | NOS | Def Tackle | 2 | 0 |
| Carl Nassib | SHR | O LB | 1 | 14 |
| Quincy Williams | NEP | Left LB | 1 | 13 |
| Kaden Elliss | PHI | Left LB | 1 | 12 |
| James Smith-Williams | PHO | Left End | 1 | 12 |
| Patrick Peterson | OAK | Left CB | 1 | 11 |
| Mykal Walker | TBB | Right I LB | 1 | 11 |
| Jimmie Ward | TBB | Safety | 1 | 11 |
| Dante Fowler | ATL | Def End | 1 | 11 |
| David Mayo | SEA | I LB | 1 | 10 |
| John Johnson III | SLC | Free Safety | 1 | 10 |
| Michael Jackson Sr. | NYJ | Left CB | 1 | 10 |
| Shaq Lawson | BAC | Right End | 1 | 10 |
| Jarran Reed | ATL | Right End | 1 | 10 |
| Austin Bryant | STL | O LB | 1 | 9 |
| Jason Pierre-Paul | NOS | Right O LB | 1 | 9 |
| Marquise Copeland | BAC | Def Tackle | 1 | 9 |
| Leki Fotu | DAL | Nose Tackle | 1 | 9 |
| Terrell Edmunds | CAR | Strong Safety | 1 | 9 |
| Terrell Lewis | SCS | O LB | 1 | 9 |
| Denzel Ward | MON | Left CB | 1 | 9 |
| Marcus Epps | PHO | Free Safety | 1 | 8 |
| Bradley Chubb | LAM | Right O LB | 1 | 8 |
| Anfernee Jennings | PHO | O LB | 1 | 8 |
| Travon Walker | OKL | Left O LB | 1 | 8 |
| Yetur Gross-Matos | CLE | Left End | 1 | 8 |
| Zach Sieler | OKL | Right End | 1 | 8 |
| Anthony Nelson | ATL | O LB | 1 | 7 |
| Jayon Brown | DAL | Left LB | 1 | 7 |
| Devin Lloyd | OAK | Left I LB | 1 | 7 |
| Matt Ioannidis | DET | Right Tackle | 1 | 7 |
| DeShon Elliott | STL | Strong Safety | 1 | 7 |
| Duron Harmon | HOO | Free Safety | 1 | 7 |
| Randy Gregory | STL | LB | 1 | 7 |
| Matt Milano | ATL | Right LB | 1 | 7 |
| Shaquil Barrett | LAC | Left O LB | 1 | 7 |
| Boye Mafe | NEP | O LB | 1 | 7 |
| Jamin Davis | DET | Left LB | 1 | 7 |
| Justin Evans | BAC | Safety | 1 | 7 |
| Cobie Durant | TOR | CB | 1 | 6 |
| L'Jarius Sneed | LAC | Left CB | 1 | 6 |
| Perrion Winfrey | LAC | Def Tackle | 1 | 5 |
| Quay Walker | GRR | Right I LB | 1 | 5 |
| Frankie Luvu | OKL | Left LB | 1 | 4 |
| Kyzir White | PHS | Right LB | 1 | 4 |
| Leonard Williams | HOO | Right End | 1 | 4 |
| John Cominsky | HAM | Right End | 1 | 4 |
| De'Vondre Campbell | MON | Left I LB | 1 | 4 |
| Marcus Peters | DAL | Left CB | 1 | 4 |
| Anthony Barr | TBB | Left LB | 1 | 3 |
| Damontae Kazee | DET | Safety | 1 | 3 |
| Joe Tryon-Shoyinka | LAC | Right O LB | 1 | 3 |
| Shaq Thompson | PHS | Middle LB | 1 | 2 |
| Nicholas Morrow | SCS | Left LB | 1 | 2 |
| Duke Riley | STL | I LB | 1 | 2 |
| Quandre Diggs | LAM | Free Safety | 1 | 1 |
| Ben Niemann | HOO | Right I LB | 1 | 0 |
| Jerome Baker | CLE | Right I LB | 1 | 0 |
| Quinton Bohanna | MON | Right Tackle | 1 | 0 |
| Cody Barton | HOU | Right I LB | 1 | 0 |
| Marlon Tuipulotu | SCS | Def Tackle | 1 | 0 |
| Arik Armstead | NOV | Right Tackle | 1 | 0 |
| Nick Bolton | CLE | Middle LB | 1 | 0 |
| Garret Wallow | NEP | I LB | 1 | 0 |
| David Long | LAM | Left I LB | 1 | 0 |
| Foyesade Oluokun | NYG | Right I LB | 1 | 0 |
| T.J. Edwards | NOV | Middle LB | 1 | 0 |
| Devin Bush | TBB | Left I LB | 1 | 0 |
| Minkah Fitzpatrick | PHS | Free Safety | 1 | 0 |
| Sum | --- | --- | 772 | 5038 |
| Avg | --- | --- | 4 | 25 |