Player_Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Dennis Gardeck | LAM | O LB | 18 | 136 |
| Rashan Gary | LAM | O LB | 17 | 107 |
| Fletcher Cox | LAC | Left Tackle | 14 | 96 |
| T.J. Watt | PHO | Left O LB | 13 | 93 |
| Frank Clark | MIC | Right End | 12 | 92 |
| Haason Reddick | LAC | Right O LB | 12 | 82 |
| Yannick Ngakoue | CLE | O LB | 11 | 74 |
| Leonard Floyd | PHO | Left O LB | 10 | 82 |
| Myles Garrett | CLE | Right End | 10 | 68 |
| Leonard Williams | CHI | Right End | 9 | 64 |
| Tyquan Lewis | LAC | Def End | 8 | 63 |
| Chris Jones | LAD | Left Tackle | 8 | 57 |
| Ndamukong Suh | LAM | Left End | 8 | 53 |
| Za'Darius Smith | MIC | Right O LB | 8 | 52 |
| Brandon Graham | BAC | Left End | 8 | 48 |
| Justin Houston | SHR | Right End | 7 | 68 |
| Aaron Donald | PHO | Right End | 7 | 55 |
| Jeff Heath | LAM | Free Safety | 7 | 46 |
| Derek Barnett | SEA | Right End | 7 | 44 |
| Carl Lawson | LAC | Right End | 7 | 39 |
| Brian Burns | DAL | Left End | 6 | 44 |
| Javon Hargrave | MIC | Right Tackle | 6 | 42 |
| Foye Oluokun | SEA | Left LB | 6 | 40 |
| DeForest Buckner | LAM | Left Tackle | 6 | 39 |
| David Onyemata | BAC | Left Tackle | 6 | 39 |
| Khalil Mack | CHI | Left O LB | 6 | 37 |
| Vita Vea | TTR | Nose Tackle | 6 | 29 |
| Montez Sweat | LAM | Right End | 5 | 44 |
| Stephon Tuitt | GBP | Left End | 5 | 37 |
| T.J. Carrie | LAM | 1st Defensive Back | 5 | 32 |
| Tershawn Wharton | CHI | Def Tackle | 5 | 27 |
| Derrick Brown | DAL | Right Tackle | 5 | 24 |
| Tyson Alualu | JAC | Nose Tackle | 5 | 15 |
| Johnathan Hankins | CAL | Right Tackle | 5 | 5 |
| Aldon Smith | CHI | Right End | 4 | 40 |
| Dexter Lawrence | CHI | Left End | 4 | 31 |
| Darius Leonard | CHI | Right LB | 4 | 28 |
| Jason Pierre-Paul | PHI | Right O LB | 4 | 28 |
| Daron Payne | OAK | Left Tackle | 4 | 27 |
| Cameron Jordan | DET | Left End | 4 | 25 |
| Jabrill Peppers | MIC | Strong Safety | 4 | 10 |
| Jaylon Ferguson | SEA | O LB | 3 | 31 |
| Malik Reed | DAL | Left O LB | 3 | 30 |
| Jihad Ward | LAC | Def End | 3 | 28 |
| Nicholas Morrow | LAC | Left LB | 3 | 27 |
| DeMarcus Lawrence | JAC | Left End | 3 | 26 |
| Denico Autry | NOS | Left End | 3 | 25 |
| Chase Winovich | GBP | Right O LB | 3 | 21 |
| Lawrence Guy | MIC | Left End | 3 | 21 |
| Tyrell Adams | DAL | Left I LB | 3 | 19 |
| Logan Ryan | PHI | Free Safety | 3 | 16 |
| Budda Baker | LAC | Strong Safety | 3 | 11 |
| Kenny Clark | GBP | Nose Tackle | 3 | 9 |
| Raekwon Davis | SEA | Nose Tackle | 3 | 4 |
| Fred Warner | PHO | Middle LB | 3 | 4 |
| Tremaine Edmunds | CLE | Middle LB | 2 | 22 |
| Anthony Averett | SHR | 1st Defensive Back | 2 | 21 |
| Jerry Hughes | SHR | Left End | 2 | 20 |
| Micah Hyde | SEA | Free Safety | 2 | 20 |
| Akiem Hicks | BUF | Left End | 2 | 19 |
| Chase Young | DAL | Left End | 2 | 18 |
| Jamie Collins | DET | Right LB | 2 | 18 |
| Trey Hendrickson | OAK | Right End | 2 | 18 |
| Everson Griffen | PHO | Def End | 2 | 17 |
| Cameron Heyward | SCS | Right End | 2 | 17 |
| Jordyn Brooks | CLE | Right LB | 2 | 17 |
| Devin White | CLE | Right I LB | 2 | 17 |
| Malcolm Smith | MIS | Left LB | 2 | 16 |
| Bobby McCain | CLE | Free Safety | 2 | 16 |
| Jonathan Allen | MIC | Right Tackle | 2 | 16 |
| Jarran Reed | CLE | Left Tackle | 2 | 16 |
| Derrick Nnadi | BAC | Right Tackle | 2 | 15 |
| Devin McCourty | DET | Free Safety | 2 | 14 |
| Bud Dupree | BAC | Right O LB | 2 | 14 |
| Dre'Mont Jones | TTR | Left End | 2 | 14 |
| Malik Jackson | DAL | Def Tackle | 2 | 14 |
| DeShon Elliott | PHO | Free Safety | 2 | 13 |
| Quinnen Williams | SCS | Right End | 2 | 13 |
| Jaylinn Hawkins | MIC | LB | 2 | 13 |
| Justin Simmons | CHI | Free Safety | 2 | 12 |
| Dante Fowler | CLE | Right End | 2 | 12 |
| Sam Hubbard | MIS | Left End | 2 | 11 |
| Bobby Wagner | SEA | Middle LB | 2 | 11 |
| Jessie Bates | CLE | Free Safety | 2 | 11 |
| Rashaan Evans | PEO | Right I LB | 2 | 10 |
| Olivier Vernon | MIS | Left End | 2 | 10 |
| Grady Jarrett | NOV | Left Tackle | 2 | 9 |
| Tim Settle | PEO | Def Tackle | 2 | 9 |
| Andrew Van Ginkel | CLE | Right O LB | 2 | 9 |
| Tarell Basham | DET | Left O LB | 2 | 5 |
| Lavonte David | JAC | Left I LB | 2 | 4 |
| Jermaine Carter | DET | Middle LB | 2 | 3 |
| DaQuan Jones | NOS | Nose Tackle | 2 | 3 |
| Minkah Fitzpatrick | MIS | Free Safety | 1 | 14 |
| Sheldon Richardson | NOV | Left Tackle | 1 | 13 |
| Joe Giles-Harris | LAM | LB | 1 | 12 |
| Ross Cockrell | DAL | 1st Defensive Back | 1 | 11 |
| Josh Sweat | DET | Def End | 1 | 11 |
| Brent Urban | PHI | Def End | 1 | 11 |
| Dalvin Tomlinson | MIS | Nose Tackle | 1 | 11 |
| Troy Reeder | CHI | Left I LB | 1 | 11 |
| Calais Campbell | BAC | Right End | 1 | 11 |
| Alex Anzalone | CHI | Middle LB | 1 | 11 |
| Karl Joseph | LAM | Strong Safety | 1 | 10 |
| Darious Williams | CLE | Left CB | 1 | 10 |
| Bradley Roby | BAC | Right CB | 1 | 10 |
| Romeo Okwara | CAL | Right End | 1 | 9 |
| Bobby Okereke | LAD | Left LB | 1 | 9 |
| Joey Bosa | PHI | Left End | 1 | 9 |
| Daniel Sorensen | SCS | Strong Safety | 1 | 8 |
| Shaquil Barrett | MIS | Left O LB | 1 | 8 |
| Kerry Hyder | SEA | Right End | 1 | 7 |
| Alexander Johnson | SHR | Right I LB | 1 | 7 |
| Deion Jones | LAM | Middle LB | 1 | 7 |
| Jordan Fuller | DAL | Strong Safety | 1 | 7 |
| Josey Jewell | SHR | Left I LB | 1 | 6 |
| Matt Milano | MIC | Right LB | 1 | 6 |
| C.J. Henderson | CLE | Left CB | 1 | 6 |
| Denzel Perryman | LAD | Middle LB | 1 | 6 |
| Adrian Phillips | PHO | Right I LB | 1 | 6 |
| Tyrann Mathieu | SCS | Free Safety | 1 | 6 |
| Alex Okafor | DAL | Def End | 1 | 6 |
| Christian Kirksey | OAK | Left I LB | 1 | 5 |
| Michael Brockers | NOV | Left End | 1 | 5 |
| Mario Edwards | LAD | Def End | 1 | 5 |
| Kenneth Murray | LAC | Right LB | 1 | 5 |
| J.J. Watt | PEO | Left End | 1 | 4 |
| Folorunso Fatukasi | PHO | Nose Tackle | 1 | 4 |
| Jason Verrett | CHI | Right CB | 1 | 3 |
| Kevin Minter | NOV | LB | 1 | 3 |
| Grover Stewart | LAD | Right Tackle | 1 | 3 |
| Ryan Kerrigan | SCS | O LB | 1 | 2 |
| Josh Allen | LAC | Left LB | 1 | 2 |
| Antwaun Woods | MIC | Left Tackle | 1 | 1 |
| Roquan Smith | BUF | Left I LB | 1 | 1 |
| Tyler Lancaster | DET | Def End | 1 | 0 |
| Cameron Dantzler | BAC | Right CB | 1 | 0 |
| Neville Hewitt | MIS | Left I LB | 1 | 0 |
| Nick Williams | PEO | Left End | 1 | 0 |
| Brandon Williams | SHR | Nose Tackle | 1 | 0 |
| DeShawn Williams | CHI | Nose Tackle | 1 | 0 |
| Sum | --- | --- | 472 | 3153 |
| Avg | --- | --- | 3 | 22 |