| League Record Book | |||||
| Passing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Completions | Joe Burrow - Cleveland | Oklahoma | 9/12/2021 | Cleveland 37-31 | 39 |
| Most Passing Yards | Aaron Rodgers - New York-NYJ | Green Bay | 9/26/2021 | New York-NYJ 43-23 | 511 |
| Best Avg Yards Per Pass | Zach Wilson - Tampa Bay | Green Bay | 9/19/2021 | Tampa Bay 31-17 | 15.5 |
| Longest Completion | Tua Tagovailoa - New Orleans-NOV | Grand Rapids | 9/26/2021 | Grand Rapids 20-17 | 83 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Completions | Cleveland | Oklahoma | 9/12/2021 | Cleveland 37-31 | 39 |
| Most Passing Yards | New York-NYJ | Green Bay | 9/26/2021 | New York-NYJ 43-23 | 511 |
| Best Avg Yards Per Pass | Tampa Bay | Green Bay | 9/19/2021 | Tampa Bay 31-17 | 15.5 |
| Longest Completion | New Orleans-NOV | Grand Rapids | 9/26/2021 | Grand Rapids 20-17 | 83 |
| Rushing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Carries | Najee Harris - Atlanta | Oklahoma | 9/26/2021 | Atlanta 17-10 | 31 |
| Most Rushing Yards | Elijah Mitchell - Los Angeles-LAC | Philadelphia-PHS | 11/14/2021 | Philadelphia-PHS 31-24 | 220 |
| Best Rushing Avg | Jordan Howard - Oklahoma | Hamilton | 10/24/2021 | Hamilton 24-16 | 11.7 |
| Longest Carry | Jonathan Taylor - St. Louis-STL | Green Bay | 9/12/2021 | St. Louis-STL 20-13 | 83 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Carries | Seattle | Baltimore | 10/24/2021 | Seattle 33-31 | 54 |
| Most Rushing Yards | Atlanta | Philadelphia-PHS | 10/24/2021 | Philadelphia-PHS 33-30 | 313 |
| Best Rushing Avg | Detroit | Philadelphia-PHS | 9/19/2021 | Philadelphia-PHS 27-10 | 10.5 |
| Longest Carry | St. Louis-STL | Green Bay | 9/12/2021 | St. Louis-STL 20-13 | 83 |
| Receiving Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Receptions | Kyle Pitts - Houston-HOU | Grand Rapids | 9/19/2021 | Houston-HOU 30-24 | 21 |
| Most Receiving Yards | Jakobi Meyers - Oklahoma | Seattle | 12/12/2021 | Seattle 30-29 | 273 |
| Best Reception Yardage Avg | Marquez Valdes-Scantlin - Houston-HOU | New York-NYJ | 11/21/2021 | Houston-HOU 41-34 | 38.5 |
| Longest Reception | Allen Lazard - New Orleans-NOV | Grand Rapids | 9/26/2021 | Grand Rapids 20-17 | 83 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Receptions | Cleveland | Oklahoma | 9/12/2021 | Cleveland 37-31 | 39 |
| Most Receiving Yards | New York-NYJ | Green Bay | 9/26/2021 | New York-NYJ 43-23 | 511 |
| Best Reception Yardage Avg | Oakland | Grand Rapids | 11/21/2021 | Oakland 30-20 | 23.1 |
| Longest Reception | New Orleans-NOV | Grand Rapids | 9/26/2021 | Grand Rapids 20-17 | 83 |
| Kickoff Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Jaylen Waddle - Green Bay | New York-NYJ | 9/26/2021 | New York-NYJ 43-23 | 6 |
| Best Return Yardage Avg | Trenton Cannon - Hamilton | Los Angeles-LAC | 12/12/2021 | Hamilton 37-26 | 99.0 |
| Longest Return | Travis Homer - Houston-HOO | New England | 10/31/2021 | Houston-HOO 32-31 | 100 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | Green Bay | New York-NYJ | 9/26/2021 | New York-NYJ 43-23 | 7 |
| Best Return Yardage Avg | Hamilton | Los Angeles-LAC | 12/12/2021 | Hamilton 37-26 | 97.0 |
| Longest Return | Houston-HOO | New England | 10/31/2021 | Houston-HOO 32-31 | 100 |
| Punt Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Ray-Ray McCloud - New Orleans-NOS | Cleveland | 10/10/2021 | New Orleans-NOS 19-10 | 5 |
| Best Return Yardage Avg | Jakeem Grant - Phoenix | Hamilton | 9/12/2021 | Phoenix 34-24 | 71.0 |
| Longest Return | Brandon Powell - Carolina | Philadelphia-PHS | 11/21/2021 | Carolina 27-9 | 81 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | Carolina | Los Angeles-LAM | 10/3/2021 | Carolina 30-27 | 5 |
| Best Return Yardage Avg | Phoenix | Hamilton | 9/12/2021 | Phoenix 34-24 | 71.0 |
| Longest Return | Carolina | Philadelphia-PHS | 11/21/2021 | Carolina 27-9 | 81 |
| Defense Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Tackles | Kyzir White - Philadelphia-PHS | New Orleans-NOV | 9/12/2021 | New Orleans-NOV 27-13 | 18 |
| Sacks | Robert Quinn - Houston-HOU | Green Bay | 10/17/2021 | Houston-HOU 34-24 | 5 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Tackles | Baltimore | Seattle | 10/24/2021 | Seattle 33-31 | 71 |
| Sacks | Houston-HOU | Southern California | 10/31/2021 | Houston-HOU 41-16 | 9 |
| Interception Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Interceptions | Budda Baker - New England | Detroit | 10/3/2021 | New England 27-21 | 3 |
| Best Interception Yardage Avg | A.J. Epenesa - New Orleans-NOV | Houston-HOO | 10/17/2021 | Houston-HOO 35-20 | 95.0 |
| Longest Interception | A.J. Epenesa - New Orleans-NOV | Houston-HOO | 10/17/2021 | Houston-HOO 35-20 | 95 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Interceptions | Tampa Bay | Detroit | 10/10/2021 | Tampa Bay 17-14 | 4 |
| Best Interception Yardage Avg | New Orleans-NOV | Houston-HOO | 10/17/2021 | Houston-HOO 35-20 | 95.0 |
| Longest Interception | New Orleans-NOV | Houston-HOO | 10/17/2021 | Houston-HOO 35-20 | 95 |