Player_Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Robert Quinn | HOU | Right O LB | 24 | 177 |
| Shaquil Barrett | LAC | Left O LB | 18 | 137 |
| T.J. Watt | ATL | Left O LB | 15 | 111 |
| Myles Garrett | STL | Right End | 13 | 98 |
| Deon Bush | HOU | Safety | 11 | 73 |
| Matt Judon | MON | Left O LB | 10 | 78 |
| Chris Jones | SLC | Right Tackle | 10 | 77 |
| Nick Bosa | NYJ | Left End | 10 | 72 |
| Maxx Crosby | LAC | Left End | 10 | 71 |
| Chandler Jones | GBP | Right O LB | 9 | 85 |
| Aaron Donald | SCS | Right End | 9 | 81 |
| Von Miller | SLC | Left O LB | 9 | 72 |
| Micah Parsons | SLC | Left LB | 9 | 55 |
| Joey Bosa | LAM | Left O LB | 8 | 69 |
| D.J. Jones | ATL | Right Tackle | 8 | 62 |
| DeForest Buckner | MON | Left Tackle | 8 | 61 |
| Cameron Jordan | NEP | Left End | 8 | 49 |
| Dorance Armstrong | DAL | Def End | 7 | 55 |
| Quinnen Williams | OAK | Right Tackle | 7 | 37 |
| Harrison Phillips | NYG | Right Tackle | 7 | 35 |
| Jimmy Smith | LAC | 1st Defensive Back | 6 | 52 |
| Christian Wilkins | ATL | Left End | 6 | 44 |
| Sam Hubbard | TBB | Left End | 6 | 43 |
| Brian Burns | CAR | Left End | 6 | 43 |
| Trey Hendrickson | GBP | Right End | 6 | 43 |
| Haason Reddick | HOO | Left LB | 6 | 41 |
| Chris Wormley | NOS | Left End | 6 | 39 |
| Kevin King | ATL | 1st Defensive Back | 6 | 34 |
| DaQuan Jones | PHI | Right Tackle | 6 | 31 |
| Tarron Jackson | SLC | Def End | 6 | 31 |
| Trevis Gipson | NEP | Left O LB | 5 | 46 |
| Azeez Ojulari | DET | Left O LB | 5 | 45 |
| Dee Ford | SLC | Def End | 5 | 39 |
| D.J. Wonnum | PHS | Right End | 5 | 38 |
| Troy Reeder | HOU | Right I LB | 5 | 38 |
| Emmanuel Ogbah | DET | Def End | 5 | 37 |
| Samson Ebukam | LAM | Right End | 5 | 36 |
| Al-Quadin Muhammad | BAC | Left End | 5 | 36 |
| Jadeveon Clowney | CLE | Left End | 5 | 35 |
| Malcolm Koonce | HOU | Def End | 5 | 31 |
| Malik McDowell | OKL | Right Tackle | 5 | 28 |
| D.J. Reader | GBP | Left Tackle | 5 | 20 |
| David Onyemata | OAK | Right Tackle | 4 | 33 |
| Daron Payne | DET | Left Tackle | 4 | 33 |
| Jonathan Allen | LAC | Right Tackle | 4 | 31 |
| Markus Golden | OAK | Left O LB | 4 | 31 |
| William Bradley-King | HOU | Def End | 4 | 30 |
| John Franklin-Myers | TBB | Left End | 4 | 30 |
| Carlos Dunlap | PHI | Def End | 4 | 30 |
| Cameron Heyward | HOO | Right End | 4 | 27 |
| Greg Rousseau | SHR | Left End | 4 | 27 |
| Larry Ogunjobi | OKL | Right Tackle | 4 | 26 |
| Fletcher Cox | LAC | Right Tackle | 4 | 23 |
| Xavier Woods | OAK | Free Safety | 4 | 21 |
| Jarran Reed | ATL | Left Tackle | 4 | 21 |
| Akiem Hicks | PHI | Left End | 4 | 21 |
| Dre'Mont Jones | GRR | Left End | 4 | 17 |
| J. Owusu-Koramoah | CAR | Right LB | 3 | 30 |
| Zaire Franklin | LAC | Right LB | 3 | 29 |
| Yannick Ngakoue | PHS | Right End | 3 | 27 |
| Derrick Brown | CAR | Left Tackle | 3 | 27 |
| Rasheem Green | OAK | Right End | 3 | 27 |
| Leonard Floyd | PHO | Right O LB | 3 | 25 |
| Harold Landry | DET | Left O LB | 3 | 23 |
| Michael Pierce | NOS | Right Tackle | 3 | 23 |
| Kamu Grugier-Hill | GRR | Right LB | 3 | 23 |
| Malcolm Smith | NEP | Left LB | 3 | 23 |
| Andre Cisco | SEA | 1st Defensive Back | 3 | 22 |
| B.J. Hill | MON | Def Tackle | 3 | 22 |
| Preston Smith | NYJ | Right O LB | 3 | 20 |
| Shelby Harris | MON | Right End | 3 | 20 |
| Carl Granderson | SHR | Def End | 3 | 19 |
| Ed Oliver | NOV | Left Tackle | 3 | 18 |
| Rodney McLeod | SLC | Free Safety | 3 | 18 |
| Shaq Lawson | BAC | Right End | 3 | 17 |
| Tyeler Davison | HOU | Nose Tackle | 3 | 17 |
| Bobby Okereke | SCS | Middle LB | 3 | 17 |
| Maliek Collins | PHO | Right Tackle | 3 | 17 |
| Eric Kendricks | LAC | Middle LB | 3 | 16 |
| Solomon Thomas | CAR | Def Tackle | 3 | 13 |
| Lawrence Guy | LAC | Left End | 3 | 13 |
| Jeffery Simmons | DET | Right End | 3 | 10 |
| Bobby Wagner | SEA | Middle LB | 3 | 7 |
| Kenny Clark | CLE | Nose Tackle | 3 | 6 |
| Marquise Copeland | BAC | Def Tackle | 3 | 0 |
| Javon Hargrave | PHS | Left Tackle | 2 | 22 |
| Bobby McCain | DET | Free Safety | 2 | 21 |
| Christian Barmore | HOU | Def Tackle | 2 | 20 |
| Tyus Bowser | CAR | Left O LB | 2 | 20 |
| Randy Gregory | STL | Right End | 2 | 20 |
| Montez Sweat | NEP | Right End | 2 | 20 |
| Alex Highsmith | NYG | Right O LB | 2 | 19 |
| Dalvin Tomlinson | NOS | Left Tackle | 2 | 18 |
| Kentavius Street | PHO | Def Tackle | 2 | 17 |
| Josh Allen | LAM | Left O LB | 2 | 17 |
| Marcus Davenport | PHO | Right End | 2 | 17 |
| DeMarcus Lawrence | DAL | Left End | 2 | 16 |
| Cassius Marsh | HOU | O LB | 2 | 15 |
| Andrew Wingard | SHR | Free Safety | 2 | 15 |
| Melvin Ingram III | HAM | Left End | 2 | 14 |
| Chase Young | PHO | Left End | 2 | 14 |
| Leonard Williams | HOO | Right End | 2 | 13 |
| William Gholston | OAK | Right End | 2 | 12 |
| Johnathan Hankins | SLC | Left Tackle | 2 | 12 |
| Azeez Al-Shaair | MON | Right LB | 2 | 12 |
| Adrian Amos | SCS | Strong Safety | 2 | 12 |
| Jonathan Greenard | CLE | Right End | 2 | 12 |
| Greg Gaines | NEP | Nose Tackle | 2 | 11 |
| Josh Sweat | NOS | Left End | 2 | 11 |
| Justin Houston | GBP | Right O LB | 2 | 11 |
| Denico Autry | SCS | Left End | 2 | 9 |
| Deatrich Wise Jr | NYJ | Right End | 2 | 8 |
| Ronald Blair III | SEA | Def End | 2 | 8 |
| Josh Uche | GRR | O LB | 2 | 8 |
| Rashan Gary | ATL | Left O LB | 2 | 8 |
| Demario Davis | DAL | Middle LB | 2 | 7 |
| Sheldon Richardson | NYJ | Def Tackle | 2 | 6 |
| Jonas Griffith | ATL | I LB | 2 | 5 |
| Jermaine Carter | SLC | Middle LB | 2 | 5 |
| Roquan Smith | CAR | Left I LB | 2 | 5 |
| Mike Purcell | HAM | Nose Tackle | 2 | 3 |
| Steve McLendon | STL | Def Tackle | 2 | 2 |
| Devin White | BAC | Right I LB | 2 | 1 |
| T.J. Edwards | NOV | Middle LB | 2 | 1 |
| Vita Vea | TBB | Nose Tackle | 2 | 0 |
| Malcolm Jenkins | NEP | Strong Safety | 1 | 14 |
| Kyle Phillips | OKL | Def End | 1 | 11 |
| Ronald Darby | NEP | Right CB | 1 | 11 |
| Adam Butler | SLC | Def End | 1 | 10 |
| Derwin James | PHS | Strong Safety | 1 | 10 |
| Byron Murphy | STL | Left CB | 1 | 10 |
| Desmond King II | SCS | Right CB | 1 | 10 |
| C.J. Mosley | OAK | Middle LB | 1 | 10 |
| Denzel Ward | MON | Right CB | 1 | 9 |
| Austin Bryant | STL | Left O LB | 1 | 9 |
| A.J. Klein | PHS | Left LB | 1 | 9 |
| Emmanuel Moseley | NYJ | Left CB | 1 | 9 |
| Ernest Jones | PHO | Left I LB | 1 | 9 |
| Arik Armstead | PHS | Left Tackle | 1 | 9 |
| Carlos Watkins | NYG | Right Tackle | 1 | 8 |
| Asante Samuel Jr. | NEP | Left CB | 1 | 8 |
| Levi Wallace | NYJ | Right CB | 1 | 8 |
| Mack Wilson | BAC | O LB | 1 | 8 |
| Blake Lynch | GRR | O LB | 1 | 7 |
| Jamin Davis | DET | Middle LB | 1 | 7 |
| A.J. Terrell | STL | Left CB | 1 | 7 |
| Germaine Pratt | GBP | Middle LB | 1 | 7 |
| Zaven Collins | STL | LB | 1 | 7 |
| Shy Tuttle | NOV | Left Tackle | 1 | 7 |
| Justin Simmons | DAL | Free Safety | 1 | 7 |
| Duron Harmon | HOO | Free Safety | 1 | 6 |
| Jordan Phillips | NYG | Left End | 1 | 6 |
| Marcus Epps | PHO | Safety | 1 | 6 |
| Dean Marlowe | STL | Strong Safety | 1 | 6 |
| Camryn Bynum | GBP | 1st Defensive Back | 1 | 6 |
| Shaq Thompson | PHS | Right LB | 1 | 6 |
| Charles Harris | CAR | Right O LB | 1 | 6 |
| Jeremy Chinn | CLE | Strong Safety | 1 | 6 |
| Travin Howard | STL | I LB | 1 | 6 |
| Derrek Tuszka | SCS | O LB | 1 | 5 |
| Andrew Van Ginkel | NYJ | Right O LB | 1 | 5 |
| Jaylon Johnson | CAR | Right CB | 1 | 5 |
| Ndamukong Suh | PHI | Left End | 1 | 5 |
| Matt Milano | ATL | Right LB | 1 | 5 |
| Jessie Bates | GRR | Free Safety | 1 | 5 |
| Taco Charlton | NOV | Def End | 1 | 4 |
| Jevon Holland | SCS | Free Safety | 1 | 4 |
| Sheldon Day | SCS | Def Tackle | 1 | 4 |
| Anthony Barr | TBB | Left LB | 1 | 4 |
| Trevon Moehrig | BAC | Free Safety | 1 | 4 |
| Kyle Van Noy | NOS | Right O LB | 1 | 4 |
| Malik Reed | NOV | Left O LB | 1 | 3 |
| David Mayo | SEA | LB | 1 | 3 |
| Justin Zimmer | SCS | Def Tackle | 1 | 2 |
| Tre'Davious White | TBB | Left CB | 1 | 2 |
| Lavonte David | GRR | Left I LB | 1 | 1 |
| Alex Anzalone | OKL | Left I LB | 1 | 1 |
| Brandon Williams | DAL | Nose Tackle | 1 | 1 |
| Poona Ford | GRR | Right Tackle | 1 | 1 |
| Anthony Walker | HOO | Middle LB | 1 | 1 |
| Christian Ringo | BAC | Def Tackle | 1 | 1 |
| Malik Harrison | CAR | I LB | 1 | 0 |
| Reggie Ragland | HOO | Left I LB | 1 | 0 |
| Grover Stewart | LAM | Right Tackle | 1 | 0 |
| Teair Tart | SEA | Nose Tackle | 1 | 0 |
| Corey Peters | HOO | Nose Tackle | 1 | 0 |
| Sum | --- | --- | 615 | 4127 |
| Avg | --- | --- | 3 | 22 |