Player_Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Brandon Graham | SEA | Left End | 14 | 100 |
| Stephon Tuitt | OAK | Left End | 13 | 88 |
| Leonard Williams | HOO | Right End | 10 | 71 |
| D.J. Jones | LON | Right Tackle | 10 | 71 |
| Haason Reddick | HOO | Right O LB | 9 | 73 |
| Myles Garrett | STL | Right End | 9 | 70 |
| Olivier Vernon | SHR | Left End | 8 | 68 |
| Chase Winovich | STL | Right O LB | 7 | 58 |
| Josh Sweat | NOS | Def End | 7 | 56 |
| Aaron Donald | SCS | Right End | 7 | 53 |
| Javon Hargrave | PHS | Right Tackle | 7 | 52 |
| DeMarcus Lawrence | DAL | Left End | 7 | 50 |
| DeForest Buckner | MON | Left Tackle | 7 | 44 |
| Za'Darius Smith | NOV | Right O LB | 7 | 37 |
| Leonard Floyd | PHO | Left O LB | 6 | 55 |
| Zach Kerr | GBP | Def Tackle | 6 | 43 |
| Sebastian Joseph-Day | HOU | Nose Tackle | 6 | 39 |
| Jonathan Allen | LAC | Right Tackle | 6 | 38 |
| Kenny Clark | CLE | Nose Tackle | 6 | 11 |
| Montez Sweat | NEP | Right End | 5 | 58 |
| Denico Autry | SCS | Left End | 5 | 45 |
| Tyus Bowser | CAR | O LB | 5 | 40 |
| Matt Judon | MON | Right O LB | 5 | 36 |
| Fletcher Cox | LAC | Left Tackle | 5 | 34 |
| Chris Jones | SLC | Left Tackle | 5 | 24 |
| David Onyemata | OAK | Left Tackle | 5 | 23 |
| Sheldon Richardson | NYJ | Left Tackle | 5 | 14 |
| Jarran Reed | DAD | Left Tackle | 5 | 12 |
| John Johnson | SHR | Free Safety | 4 | 36 |
| Romeo Okwara | CAR | Right End | 4 | 36 |
| Anthony Chickillo | HOU | O LB | 4 | 35 |
| Roquan Smith | CAR | Left I LB | 4 | 32 |
| AJ Klein | OAK | Left LB | 4 | 31 |
| Rashan Gary | LON | O LB | 4 | 30 |
| Quinnen Williams | OAK | Right End | 4 | 29 |
| Calais Campbell | GRR | Right End | 4 | 29 |
| Vinny Curry | HOU | Def End | 4 | 28 |
| Derek Barnett | LON | Right End | 4 | 27 |
| Chris Banjo | NYG | Free Safety | 4 | 27 |
| Todd Davis | SEA | Right LB | 4 | 27 |
| Genard Avery | SLC | Def End | 4 | 26 |
| Kerry Hyder | DAL | Right End | 4 | 25 |
| Bud Dupree | NEP | Right O LB | 4 | 24 |
| Daron Payne | DET | Left Tackle | 4 | 20 |
| Ndamukong Suh | PHI | Left End | 4 | 20 |
| Avery Williamson | OAK | I LB | 4 | 13 |
| Everson Griffen | LAC | Def End | 3 | 29 |
| Frank Clark | OKL | Right End | 3 | 28 |
| Chase Young | PHO | Left End | 3 | 28 |
| Dre Kirkpatrick | SEA | Right CB | 3 | 27 |
| Brent Urban | SHR | Def End | 3 | 24 |
| Dennis Gardeck | HOU | O LB | 3 | 22 |
| William Gholston | NOV | Right End | 3 | 22 |
| Joey Bosa | LAM | Left End | 3 | 21 |
| T.J. Watt | DAD | Left O LB | 3 | 20 |
| Khalil Mack | HOO | Left O LB | 3 | 20 |
| Maxx Crosby | LAC | Left End | 3 | 19 |
| Jessie Bates | GRR | Free Safety | 3 | 19 |
| Shaquil Barrett | LAC | Left O LB | 3 | 18 |
| Deion Jones | NEP | Middle LB | 3 | 16 |
| Folorunso Fatukasi | NEP | Nose Tackle | 3 | 15 |
| Bradley Chubb | LAM | Right O LB | 3 | 14 |
| Al-Quadin Muhammad | DAD | Def Tackle | 3 | 14 |
| Devin White | LON | Right I LB | 3 | 11 |
| Jayon Brown | NYG | Left I LB | 3 | 8 |
| Byron Cowart | STL | Nose Tackle | 3 | 7 |
| Logan Ryan | SEA | Free Safety | 3 | 7 |
| Derrick Nnadi | NYG | Right Tackle | 3 | 6 |
| Joe Schobert | DET | Middle LB | 3 | 4 |
| Denzel Perryman | SHR | Middle LB | 3 | 4 |
| Malcom Brown | LAM | Right Tackle | 3 | 3 |
| De'Vondre Campbell | NOS | Right I LB | 3 | 3 |
| Tyson Alualu | HOO | Nose Tackle | 3 | 0 |
| Emmanuel Ogbah | DET | Left End | 2 | 23 |
| Nick Kwiatkoski | DAD | Middle LB | 2 | 20 |
| Morgan Fox | LAM | Def End | 2 | 20 |
| Aldon Smith | HAM | Right End | 2 | 19 |
| Troy Reeder | HOU | Left I LB | 2 | 19 |
| Harold Landry | DET | Right O LB | 2 | 17 |
| Jerry Tillery | CAR | Right End | 2 | 17 |
| Eric Kendricks | LAC | Middle LB | 2 | 17 |
| Sam Hubbard | TBB | Left End | 2 | 17 |
| Tre Boston | SCS | Free Safety | 2 | 17 |
| Kyle Van Noy | DAL | Left O LB | 2 | 16 |
| Markus Golden | OAK | Left O LB | 2 | 16 |
| Efe Obada | SEA | Def End | 2 | 15 |
| Jerome Baker | CLE | Left I LB | 2 | 15 |
| Justin Jones | PHO | Left Tackle | 2 | 14 |
| Tashaun Gipson | GBP | Free Safety | 2 | 13 |
| Zach Sieler | OKL | Def Tackle | 2 | 13 |
| Barkevious Mingo | HAM | O LB | 2 | 13 |
| Raekwon McMillan | STL | LB | 2 | 12 |
| Pernell McPhee | SLC | Left O LB | 2 | 12 |
| Michael Brockers | TBB | Left End | 2 | 12 |
| Shilique Calhoun | PHO | O LB | 2 | 11 |
| Yannick Ngakoue | CLE | O LB | 2 | 11 |
| Robert Quinn | HOU | Right O LB | 2 | 11 |
| Shelby Harris | MON | Right End | 2 | 11 |
| Derrick Brown | CAR | Right Tackle | 2 | 10 |
| Linval Joseph | PHO | Right Tackle | 2 | 9 |
| Micah Kiser | TBB | Right I LB | 2 | 4 |
| Rashaan Evans | LON | Right I LB | 2 | 4 |
| Bravvion Roy | GBP | Left Tackle | 2 | 4 |
| Robert Spillane | NOS | Right I LB | 2 | 3 |
| Grover Stewart | SEA | Right Tackle | 2 | 1 |
| Minkah Fitzpatrick | PHS | Free Safety | 2 | 1 |
| Tyeler Davison | NYJ | Right Tackle | 2 | 1 |
| Alex Anzalone | OKL | Middle LB | 2 | 0 |
| DaQuan Jones | PHI | Nose Tackle | 2 | 0 |
| Dalvin Tomlinson | NOS | Nose Tackle | 2 | 0 |
| Josey Jewell | NYJ | Left I LB | 2 | 0 |
| Malik Jackson | HOO | Def Tackle | 1 | 12 |
| Tyrell Adams | PHI | Left I LB | 1 | 12 |
| Anthony Nelson | DAD | O LB | 1 | 12 |
| J.C. Jackson | CAR | Left CB | 1 | 12 |
| Brian Burns | CAR | Left End | 1 | 11 |
| Uchenna Nwosu | NYJ | O LB | 1 | 10 |
| Cameron Heyward | HOO | Right End | 1 | 10 |
| Julian Blackmon | HOU | Free Safety | 1 | 10 |
| Rakeem Nunez-Roches | DET | Def Tackle | 1 | 10 |
| Sione Takitaki | DET | Right LB | 1 | 10 |
| Nicholas Morrow | SCS | Left LB | 1 | 10 |
| Carl Lawson | NYJ | Right End | 1 | 9 |
| Malcolm Smith | NEP | Left LB | 1 | 9 |
| Jonathan Bostic | SHR | Middle LB | 1 | 9 |
| Jerry Hughes | SEA | Left End | 1 | 9 |
| Harrison Smith | DAL | Strong Safety | 1 | 9 |
| Carlos Watkins | NYG | Right End | 1 | 9 |
| Marcus Epps | PHO | Safety | 1 | 9 |
| Justin Houston | GBP | Right End | 1 | 9 |
| Cole Holcomb | LAC | Left LB | 1 | 8 |
| Dexter Lawrence | GRR | Left End | 1 | 8 |
| Marcus Peters | HOO | Left CB | 1 | 8 |
| Trevon Diggs | OAK | Right CB | 1 | 8 |
| Antwaun Woods | NOV | Left Tackle | 1 | 7 |
| Blessuan Austin | SCS | Right CB | 1 | 7 |
| Darius Phillips | DET | Left CB | 1 | 7 |
| Bobby Okereke | SCS | Left LB | 1 | 7 |
| Patrick Peterson | OAK | Left CB | 1 | 7 |
| Marcus Maye | OAK | Free Safety | 1 | 7 |
| Fred Warner | PHI | Middle LB | 1 | 7 |
| Jeremy Chinn | CLE | Left LB | 1 | 7 |
| Joe Giles-Harris | HAM | LB | 1 | 6 |
| Eric Wilson | LAM | Left LB | 1 | 6 |
| Anthony Hitchens | NEP | Middle LB | 1 | 6 |
| J.J. Watt | GBP | Left End | 1 | 6 |
| Damarious Randall | LON | 1st Defensive Back | 1 | 6 |
| Jayrone Elliott | CAR | O LB | 1 | 6 |
| Ryan Kerrigan | DAL | O LB | 1 | 6 |
| Bobby McCain | DET | Free Safety | 1 | 5 |
| Jaleel Johnson | SEA | Left Tackle | 1 | 5 |
| Mario Edwards | NYJ | Def End | 1 | 5 |
| Fabian Moreau | STL | 1st Defensive Back | 1 | 5 |
| Trey Hendrickson | GBP | Right End | 1 | 5 |
| Alex Highsmith | NYG | O LB | 1 | 5 |
| Grady Jarrett | SCS | Left Tackle | 1 | 5 |
| Lawrence Guy | LAC | Left End | 1 | 5 |
| William Jackson | CLE | Right CB | 1 | 5 |
| Andrew Van Ginkel | NYJ | Right O LB | 1 | 4 |
| Jason Verrett | NOS | Right CB | 1 | 4 |
| Ed Oliver | NOV | Right Tackle | 1 | 4 |
| L.J. Collier | PHS | Right End | 1 | 4 |
| Matt Milano | LON | Right LB | 1 | 3 |
| Arik Armstead | CLE | Left End | 1 | 3 |
| Cameron Jordan | NEP | Left End | 1 | 2 |
| Jason Pierre-Paul | MON | Right O LB | 1 | 2 |
| Poona Ford | GRR | Right Tackle | 1 | 1 |
| T.J. Edwards | NOV | Middle LB | 1 | 1 |
| Jordan Hicks | HAM | Left I LB | 1 | 0 |
| Shaq Thompson | PHS | Right LB | 1 | 0 |
| Bobby Wagner | SEA | Middle LB | 1 | 0 |
| Azeez Al-Shaair | MON | Right LB | 1 | 0 |
| Vince Williams | TBB | Left I LB | 1 | 0 |
| Ja'Whaun Bentley | HAM | Left I LB | 1 | 0 |
| Lavonte David | GRR | Left I LB | 1 | 0 |
| Jermaine Carter | SLC | Middle LB | 1 | 0 |
| Markus Bailey | PHS | I LB | 1 | 0 |
| Sum | --- | --- | 492 | 3079 |
| Avg | --- | --- | 3 | 17 |