| League Record Book | |||||
| Passing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Completions | Richard Todd - New York AFC | Miami | 10/4/1981 | New York AFC 44-21 | 34 |
| Most Passing Yards | Dan Fouts - San Diego | Chicago | 10/25/1981 | Chicago 33-31 | 467 |
| Best Avg Yards Per Pass | Joe Theismann - Washington | Baltimore | 12/13/1981 | Washington 41-16 | 14.7 |
| Longest Completion | Ken "Snake" Stabler - Houston | Seattle | 10/11/1981 | Seattle 19-9 | 82 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Completions | New York AFC | Miami | 10/4/1981 | New York AFC 44-21 | 34 |
| Most Passing Yards | San Diego | Chicago | 10/25/1981 | Chicago 33-31 | 467 |
| Best Avg Yards Per Pass | Washington | Baltimore | 12/13/1981 | Washington 41-16 | 14.7 |
| Longest Completion | Houston | Seattle | 10/11/1981 | Seattle 19-9 | 82 |
| Rushing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Carries | Walter Payton - Chicago | Minnesota | 10/4/1981 | Minnesota 20-17 | 34 |
| Most Rushing Yards | Tony Dorsett - Dallas | New England | 9/21/1981 | Dallas 35-21 | 226 |
| Best Rushing Avg | Kenny L. King - Oakland | New England | 11/1/1981 | New England 31-17 | 12.9 |
| Longest Carry | Tony Dorsett - Dallas | New York NFC | 9/27/1981 | Dallas 34-0 | 75 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Carries | Oakland | Denver | 10/4/1981 | Oakland 9-6 | 52 |
| Most Rushing Yards | Dallas | New England | 9/21/1981 | Dallas 35-21 | 316 |
| Best Rushing Avg | Oakland | New England | 11/1/1981 | New England 31-17 | 8.7 |
| Longest Carry | Dallas | New York NFC | 9/27/1981 | Dallas 34-0 | 75 |
| Receiving Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Receptions | Bennie Cunningham - Pittsburgh | New Orleans | 10/4/1981 | Pittsburgh 43-0 | 14 |
| Most Receiving Yards | Steve Largent - Seattle | New York AFC | 12/6/1981 | New York AFC 27-14 | 237 |
| Best Reception Yardage Avg | Steve Largent - Seattle | New York AFC | 12/6/1981 | New York AFC 27-14 | 33.9 |
| Longest Reception | Ken Burrough - Houston | Seattle | 10/11/1981 | Seattle 19-9 | 82 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Receptions | New York AFC | Miami | 10/4/1981 | New York AFC 44-21 | 34 |
| Most Receiving Yards | San Diego | Chicago | 10/25/1981 | Chicago 33-31 | 467 |
| Best Reception Yardage Avg | New England | Miami | 12/6/1981 | Miami 23-20 | 21.1 |
| Longest Reception | Houston | Seattle | 10/11/1981 | Seattle 19-9 | 82 |
| Kickoff Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Mike Nelms - Washington | San Francisco | 10/4/1981 | San Francisco 45-14 | 8 |
| Best Return Yardage Avg | Amos Lawrence - San Francisco | Washington | 10/4/1981 | San Francisco 45-14 | 85.0 |
| Longest Return | Willie Tullis - Houston | Los Angeles | 9/6/1981 | Los Angeles 24-14 | 92 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | Oakland | San Diego | 11/22/1981 | San Diego 48-0 | 9 |
| Best Return Yardage Avg | New Orleans | St. Louis | 12/6/1981 | New Orleans 34-0 | 57.0 |
| Longest Return | Houston | Los Angeles | 9/6/1981 | Los Angeles 24-14 | 92 |
| Punt Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | James Jones Jr. - Dallas | New York NFC | 9/27/1981 | Dallas 34-0 | 8 |
| Best Return Yardage Avg | Robbie Martin - Detroit | Tampa Bay | 10/4/1981 | Tampa Bay 27-20 | 89.0 |
| Longest Return | Tommy Vigorito - Miami | New England | 12/6/1981 | Miami 23-20 | 93 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | Dallas | New York NFC | 9/27/1981 | Dallas 34-0 | 8 |
| Best Return Yardage Avg | Detroit | Tampa Bay | 10/4/1981 | Tampa Bay 27-20 | 89.0 |
| Longest Return | Miami | New England | 12/6/1981 | Miami 23-20 | 93 |
| Defense Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Tackles | Terry Beeson - Seattle | Kansas City | 9/27/1981 | Kansas City 27-21 | 19 |
| Sacks | Harvey Martin - Dallas | San Francisco | 10/11/1981 | Dallas 23-3 | 4 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Tackles | Cincinnati | Pittsburgh | 10/18/1981 | Cincinnati 34-27 | 64 |
| Sacks | Cleveland | Los Angeles | 10/4/1981 | Cleveland 24-17 | 8 |
| Interception Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Interceptions | Dwight Hicks - San Francisco | Washington | 10/4/1981 | San Francisco 45-14 | 3 |
| Best Interception Yardage Avg | Tom Pridemore - Atlanta | San Francisco | 11/8/1981 | Atlanta 21-19 | 99.0 |
| Longest Interception | Cedric Brown - Tampa Bay | Green Bay | 11/22/1981 | Tampa Bay 37-6 | 102 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Interceptions | Pittsburgh | New Orleans | 10/4/1981 | Pittsburgh 43-0 | 6 |
| Best Interception Yardage Avg | Atlanta | San Francisco | 11/8/1981 | Atlanta 21-19 | 99.0 |
| Longest Interception | Tampa Bay | Green Bay | 11/22/1981 | Tampa Bay 37-6 | 102 |