| Game Results |
| Teams | Date | Score |
| Atlanta at Chicago | 9/17/1972 | ATN 16-7 |
| Cincinnati at New England | 9/17/1972 | NEA 16-14 |
| Philadelphia at Dallas | 9/17/1972 | DAN 38-31 |
| Houston at Denver | 9/17/1972 | DEA 30-24 |
| New York NFC at Detroit | 9/17/1972 | NYN 30-10 |
| Green Bay at Cleveland | 9/17/1972 | GBN 9-7 |
| New Orleans at Los Angeles | 9/17/1972 | LAN 38-17 |
| Miami at Kansas City | 9/17/1972 | MIA 36-0 |
| New York AFC at Buffalo | 9/17/1972 | NYA 31-27 |
| Oakland at Pittsburgh | 9/17/1972 | PIA 34-28 |
| San Diego at San Francisco | 9/17/1972 | SFN 34-24 |
| St. Louis at Baltimore | 9/17/1972 | BAA 27-16 |
| Washington at Minnesota | 9/18/1972 | WAN 31-31 |
| San Francisco at Buffalo | 9/24/1972 | SFN 38-10 |
| Pittsburgh at Cincinnati | 9/24/1972 | PIA 45-13 |
| Cleveland at Philadelphia | 9/24/1972 | CLA 37-0 |
| Dallas at New York NFC | 9/24/1972 | DAN 42-24 |
| Los Angeles at Chicago | 9/24/1972 | LAN 27-10 |
| Houston at Miami | 9/24/1972 | MIA 44-14 |
| Minnesota at Detroit | 9/24/1972 | DEN 24-21 |
| Atlanta at New England | 9/24/1972 | ATN 17-3 |
| New York AFC at Baltimore | 9/24/1972 | BAA 38-16 |
| Oakland at Green Bay | 9/24/1972 | OAA 27-9 |
| Denver at San Diego | 9/24/1972 | DEA 21-17 |
| St. Louis at Washington | 9/24/1972 | WAN 21-16 |
| Kansas City at New Orleans | 9/25/1972 | KCA 30-7 |
| Los Angeles at Atlanta | 10/1/1972 | ATN 35-17 |
| Baltimore at Buffalo | 10/1/1972 | BAA 17-9 |
| Cincinnati at Cleveland | 10/1/1972 | CIA 31-17 |
| Detroit at Chicago | 10/1/1972 | CHN 16-14 |
| Dallas at Green Bay | 10/1/1972 | DAN 13-10 |
| New York AFC at Houston | 10/1/1972 | NYA 41-17 |
| Kansas City at Denver | 10/1/1972 | KCA 34-6 |
| Miami at Minnesota | 10/1/1972 | MIA 34-14 |
| Washington at New England | 10/1/1972 | WAN 23-13 |
| Pittsburgh at St. Louis | 10/1/1972 | PIA 38-0 |
| San Diego at Oakland | 10/1/1972 | OAA 38-20 |
| San Francisco at New Orleans | 10/1/1972 | SFN 24-6 |
| New York NFC at Philadelphia | 10/2/1972 | NYN 23-3 |
| New England at Buffalo | 10/8/1972 | NEA 24-17 |
| Denver at Cincinnati | 10/8/1972 | CIA 54-6 |
| Pittsburgh at Dallas | 10/8/1972 | PIA 54-14 |
| Detroit at Atlanta | 10/8/1972 | DEN 31-30 |
| Chicago at Green Bay | 10/8/1972 | GBN 18-13 |
| Kansas City at Cleveland | 10/8/1972 | CLA 26-20 |
| San Francisco at Los Angeles | 10/8/1972 | SFN 31-30 |
| Miami at New York AFC | 10/8/1972 | MIA 47-0 |
| New Orleans at New York NFC | 10/8/1972 | NYN 26-0 |
| San Diego at Baltimore | 10/8/1972 | BAA 45-6 |
| St. Louis at Minnesota | 10/8/1972 | MIN 13-6 |
| Philadelphia at Washington | 10/8/1972 | WAN 31-6 |
| Oakland at Houston | 10/9/1972 | OAA 31-13 |
| Atlanta at New Orleans | 10/15/1972 | ATN 24-14 |
| Chicago at Cleveland | 10/15/1972 | CLA 12-10 |
| Cincinnati at Kansas City | 10/15/1972 | CIA 24-13 |
| Dallas at Baltimore | 10/15/1972 | BAA 28-0 |
| Los Angeles at Philadelphia | 10/15/1972 | LAN 27-16 |
| San Diego at Miami | 10/15/1972 | MIA 33-21 |
| Minnesota at Denver | 10/15/1972 | MIN 27-24 |
| New York NFC at San Francisco | 10/15/1972 | NYN 30-23 |
| New York AFC at New England | 10/15/1972 | NYA 42-14 |
| Buffalo at Oakland | 10/15/1972 | OAA 24-14 |
| Houston at Pittsburgh | 10/15/1972 | PIA 17-16 |
| Washington at St. Louis | 10/15/1972 | WAN 38-3 |
| Green Bay at Detroit | 10/16/1972 | DEN 27-23 |
| Atlanta at Green Bay | 10/22/1972 | ATN 20-6 |
| Cleveland at Houston | 10/22/1972 | CLA 13-7 |
| Denver at Oakland | 10/22/1972 | OAA 23-17 |
| San Diego at Detroit | 10/22/1972 | DEN 17-13 |
| Cincinnati at Los Angeles | 10/22/1972 | LAN 34-27 |
| Buffalo at Miami | 10/22/1972 | MIA 44-3 |
| New Orleans at San Francisco | 10/22/1972 | SFN 33-17 |
| St. Louis at New York NFC | 10/22/1972 | NYN 34-14 |
| Baltimore at New York AFC | 10/22/1972 | BAA 34-31 |
| Philadelphia at Kansas City | 10/22/1972 | KCA 24-9 |
| New England at Pittsburgh | 10/22/1972 | PIA 37-0 |
| Dallas at Washington | 10/22/1972 | DAN 24-24 |
| Minnesota at Chicago | 10/23/1972 | CHN 13-10 |
| Chicago at St. Louis | 10/29/1972 | CHN 20-17 |
| Houston at Cincinnati | 10/29/1972 | CIA 35-10 |
| Cleveland at Denver | 10/29/1972 | DEA 30-24 |
| Kansas City at San Diego | 10/29/1972 | KCA 32-10 |
| Miami at Baltimore | 10/29/1972 | MIA 27-14 |
| Minnesota at Green Bay | 10/29/1972 | MIN 20-3 |
| Philadelphia at New Orleans | 10/29/1972 | NON 28-16 |
| New England at New York AFC | 10/29/1972 | NYA 37-7 |
| Los Angeles at Oakland | 10/29/1972 | LAN 30-28 |
| Pittsburgh at Buffalo | 10/29/1972 | BUA 23-21 |
| San Francisco at Atlanta | 10/29/1972 | SFN 20-13 |
| Washington at New York NFC | 10/29/1972 | NYN 27-0 |
| Detroit at Dallas | 10/30/1972 | DAN 28-20 |
| Houston at Cleveland | 11/5/1972 | CLA 34-10 |
| Dallas at San Diego | 11/5/1972 | DAN 35-31 |
| Chicago at Detroit | 11/5/1972 | DEN 24-17 |
| San Francisco at Green Bay | 11/5/1972 | SFN 23-23 |
| Oakland at Kansas City | 11/5/1972 | KCA 26-10 |
| Atlanta at Los Angeles | 11/5/1972 | ATN 27-24 |
| Miami at Buffalo | 11/5/1972 | MIA 26-3 |
| New Orleans at Minnesota | 11/5/1972 | MIN 34-21 |
| Denver at New York NFC | 11/5/1972 | NYN 27-24 |
| Cincinnati at Pittsburgh | 11/5/1972 | CIA 13-7 |
| St. Louis at Philadelphia | 11/5/1972 | PHN 33-20 |
| Washington at New York AFC | 11/5/1972 | WAN 24-10 |
| Baltimore at New England | 11/6/1972 | BAA 17-17 |
| New Orleans at Atlanta | 11/12/1972 | ATN 45-21 |
| St. Louis at Dallas | 11/12/1972 | DAN 31-7 |
| Denver at Los Angeles | 11/12/1972 | DEA 27-27 |
| Green Bay at Chicago | 11/12/1972 | GBN 20-17 |
| New England at Miami | 11/12/1972 | MIA 19-0 |
| Detroit at Minnesota | 11/12/1972 | DEN 41-23 |
| Buffalo at New York AFC | 11/12/1972 | NYA 31-10 |
| Oakland at Cincinnati | 11/12/1972 | OAA 21-20 |
| Philadelphia at Houston | 11/12/1972 | HOA 16-14 |
| Kansas City at Pittsburgh | 11/12/1972 | PIA 38-14 |
| Baltimore at San Francisco | 11/12/1972 | BAA 28-10 |
| New York NFC at Washington | 11/12/1972 | NYN 20-20 |
| Cleveland at San Diego | 11/13/1972 | CLA 16-3 |
| Baltimore at Cincinnati | 11/19/1972 | BAA 24-20 |
| Buffalo at New England | 11/19/1972 | BUA 35-21 |
| Pittsburgh at Cleveland | 11/19/1972 | PIA 30-6 |
| Dallas at Philadelphia | 11/19/1972 | DAN 24-3 |
| New Orleans at Detroit | 11/19/1972 | DEN 33-21 |
| Green Bay at Houston | 11/19/1972 | GBN 17-14 |
| New York AFC at Miami | 11/19/1972 | MIA 34-10 |
| Minnesota at Los Angeles | 11/19/1972 | MIN 13-6 |
| New York NFC at St. Louis | 11/19/1972 | NYN 34-9 |
| Oakland at Denver | 11/19/1972 | OAA 34-27 |
| San Diego at Kansas City | 11/19/1972 | KCA 28-10 |
| San Francisco at Chicago | 11/19/1972 | SFN 28-24 |
| Atlanta at Washington | 11/20/1972 | ATN 24-24 |
| New York AFC at Detroit | 11/23/1972 | NYA 35-24 |
| San Francisco at Dallas | 11/23/1972 | SFN 31-0 |
| Denver at Atlanta | 11/26/1972 | ATN 34-21 |
| New England at Baltimore | 11/26/1972 | BAA 21-17 |
| Cincinnati at Chicago | 11/26/1972 | CIA 42-16 |
| Buffalo at Cleveland | 11/26/1972 | CLA 34-6 |
| Los Angeles at New Orleans | 11/26/1972 | NON 20-13 |
| Philadelphia at New York NFC | 11/26/1972 | NYN 30-14 |
| Kansas City at Oakland | 11/26/1972 | OAA 28-23 |
| Minnesota at Pittsburgh | 11/26/1972 | PIA 24-3 |
| Houston at San Diego | 11/26/1972 | SDA 20-17 |
| Green Bay at Washington | 11/26/1972 | GBN 20-0 |
| St. Louis at Miami | 11/27/1972 | MIA 33-3 |
| Houston at Atlanta | 12/3/1972 | ATN 30-20 |
| Buffalo at Baltimore | 12/3/1972 | BAA 27-3 |
| New York NFC at Cincinnati | 12/3/1972 | NYN 27-14 |
| Dallas at St. Louis | 12/3/1972 | DAN 21-9 |
| Detroit at Green Bay | 12/3/1972 | DEN 16-3 |
| Denver at Kansas City | 12/3/1972 | KCA 23-9 |
| Miami at New England | 12/3/1972 | MIA 34-14 |
| Chicago at Minnesota | 12/3/1972 | MIN 24-6 |
| New Orleans at New York AFC | 12/3/1972 | NYA 26-3 |
| Oakland at San Diego | 12/3/1972 | OAA 35-21 |
| Cleveland at Pittsburgh | 12/3/1972 | PIA 24-13 |
| Washington at Philadelphia | 12/3/1972 | WAN 52-7 |
| Los Angeles at San Francisco | 12/4/1972 | SFN 24-10 |
| Cleveland at Cincinnati | 12/9/1972 | CIA 24-7 |
| Washington at Dallas | 12/9/1972 | WAN 19-14 |
| Chicago at Philadelphia | 12/10/1972 | CHN 30-7 |
| San Diego at Denver | 12/10/1972 | DEA 45-10 |
| Detroit at Buffalo | 12/10/1972 | BUA 17-16 |
| Green Bay at Minnesota | 12/10/1972 | MIN 37-10 |
| Baltimore at Kansas City | 12/10/1972 | KCA 28-24 |
| Miami at New York NFC | 12/10/1972 | MIA 38-27 |
| New England at New Orleans | 12/10/1972 | NEA 28-13 |
| Pittsburgh at Houston | 12/10/1972 | PIA 41-3 |
| Atlanta at San Francisco | 12/10/1972 | SFN 33-24 |
| Los Angeles at St. Louis | 12/10/1972 | LAN 22-0 |
| New York AFC at Oakland | 12/11/1972 | OAA 55-14 |
| Baltimore at Miami | 12/16/1972 | MIA 30-7 |
| Minnesota at San Francisco | 12/16/1972 | SFN 35-30 |
| Buffalo at Washington | 12/17/1972 | WAN 43-17 |
| Cincinnati at Houston | 12/17/1972 | CIA 27-10 |
| Cleveland at New York AFC | 12/17/1972 | NYA 27-23 |
| New England at Denver | 12/17/1972 | DEA 40-24 |
| Detroit at Los Angeles | 12/17/1972 | LAN 27-17 |
| Green Bay at New Orleans | 12/17/1972 | NON 24-13 |
| Kansas City at Atlanta | 12/17/1972 | KCA 19-17 |
| New York NFC at Dallas | 12/17/1972 | NYN 20-17 |
| Chicago at Oakland | 12/17/1972 | OAA 23-20 |
| Pittsburgh at San Diego | 12/17/1972 | PIA 31-26 |
| Philadelphia at St. Louis | 12/17/1972 | SLN 31-10 |