| Passing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Completions | Sonny Jurgensen - Washington | New York NFL | 11/7/1965 | New York NFL 28-20 | 34 |
| Most Passing Yards | Charley Johnson - St. Louis | Los Angeles | 12/5/1965 | St. Louis 30-20 | 401 |
| Best Avg Yards Per Pass | Sonny Jurgensen - Washington | Pittsburgh | 11/21/1965 | Washington 54-0 | 14.0 |
| Longest Completion | Earl Morrall - New York NFL | Washington | 11/7/1965 | New York NFL 28-20 | 86 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Completions | Washington | New York NFL | 11/7/1965 | New York NFL 28-20 | 34 |
| Most Passing Yards | St. Louis | Los Angeles | 12/5/1965 | St. Louis 30-20 | 401 |
| Best Avg Yards Per Pass | Washington | Pittsburgh | 11/21/1965 | Washington 54-0 | 13.4 |
| Longest Completion | New York NFL | Washington | 11/7/1965 | New York NFL 28-20 | 86 |
| Rushing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Carries | Jim Brown - Cleveland | Pittsburgh | 11/28/1965 | Cleveland 24-6 | 31 |
| Most Rushing Yards | Timmy Brown - Philadelphia | Detroit | 12/19/1965 | Detroit 20-14 | 190 |
| Best Rushing Avg | Gale Sayers - Chicago | Detroit | 11/21/1965 | Chicago 42-24 | 10.8 |
| Longest Carry | Wray Carlton - Buffalo | Kansas City | 12/12/1965 | Kansas City 19-14 | 74 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Carries | Baltimore | Chicago | 11/7/1965 | Baltimore 20-10 | 57 |
| Most Rushing Yards | Minnesota | Green Bay | 12/5/1965 | Green Bay 27-21 | 296 |
| Best Rushing Avg | Philadelphia | Detroit | 12/19/1965 | Detroit 20-14 | 7.4 |
| Longest Carry | Buffalo | Kansas City | 12/12/1965 | Kansas City 19-14 | 74 |
| Receiving Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Receptions | Dave Parks - San Francisco | Los Angeles | 11/21/1965 | Los Angeles 36-31 | 11 |
| Most Receiving Yards | Don Maynard - New York AFL | San Diego | 10/23/1965 | San Diego 35-27 | 189 |
| Best Reception Yardage Avg | Don Maynard - New York AFL | San Diego | 10/23/1965 | San Diego 35-27 | 37.8 |
| Longest Reception | Homer Jones - New York NFL | Washington | 11/7/1965 | New York NFL 28-20 | 86 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Receptions | Washington | New York NFL | 11/7/1965 | New York NFL 28-20 | 34 |
| Most Receiving Yards | St. Louis | Los Angeles | 12/5/1965 | St. Louis 30-20 | 401 |
| Best Reception Yardage Avg | Houston | Oakland | 9/26/1965 | Houston 28-25 | 25.8 |
| Longest Reception | New York NFL | Washington | 11/7/1965 | New York NFL 28-20 | 86 |
| Kickoff Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Charley Warner - Buffalo | Oakland | 10/3/1965 | Oakland 44-20 | 7 |
| Best Return Yardage Avg | Dave Osborn - Minnesota | Detroit | 9/26/1965 | Minnesota 24-21 | 91.0 |
| Longest Return | Lance Rentzel - Minnesota | San Francisco | 10/24/1965 | Minnesota 41-37 | 100 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | Buffalo | Oakland | 10/3/1965 | Oakland 44-20 | 9 |
| Best Return Yardage Avg | Kansas City | Denver | 10/10/1965 | Kansas City 22-6 | 52.0 |
| Longest Return | Minnesota | San Francisco | 10/24/1965 | Minnesota 41-37 | 100 |
| Punt Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Jim Stiger - Los Angeles | Chicago | 9/25/1965 | Los Angeles 28-7 | 7 |
| Best Return Yardage Avg | Abner Haynes - Denver | Buffalo | 9/19/1965 | Buffalo 27-20 | 93.0 |
| Longest Return | Abner Haynes - Denver | Buffalo | 9/19/1965 | Buffalo 27-20 | 93 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | Los Angeles | Chicago | 9/25/1965 | Los Angeles 28-7 | 8 |
| Best Return Yardage Avg | San Diego | Kansas City | 9/26/1965 | San Diego 31-0 | 86.0 |
| Longest Return | Denver | Buffalo | 9/19/1965 | Buffalo 27-20 | 93 |
| Defense Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Tackles | Dick Butkus - Chicago | Baltimore | 11/7/1965 | Baltimore 20-10 | 23 |
| Sacks | Willie Davis - Green Bay | Detroit | 10/17/1965 | Green Bay 20-10 | 5 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Tackles | Minnesota | Baltimore | 9/19/1965 | Baltimore 26-17 | 70 |
| Sacks | Los Angeles | Green Bay | 11/14/1965 | Los Angeles 21-16 | 10 |
| Interception Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Interceptions | Pat Fischer - St. Louis | Washington | 10/10/1965 | Washington 6-3 | 3 |
| Best Interception Yardage Avg | Speedy Duncan - San Diego | Buffalo | 10/10/1965 | San Diego 52-7 | 102.0 |
| Longest Interception | Speedy Duncan - San Diego | Buffalo | 10/10/1965 | San Diego 52-7 | 102 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Interceptions | Oakland | Boston | 10/8/1965 | Oakland 28-14 | 6 |
| Best Interception Yardage Avg | Pittsburgh | Dallas | 10/31/1965 | Dallas 28-15 | 76.0 |
| Longest Interception | San Diego | Buffalo | 10/10/1965 | San Diego 52-7 | 102 |